|Budget Amount *help
¥88,790,000 (Direct Cost: ¥68,300,000、Indirect Cost: ¥20,490,000)
Fiscal Year 2012: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2009: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2008: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Using ultra-high field NMR spectroscopy in conjunction with other biophysical methods, we characterized conformational fluctuations of proteins and glycoconjugates as well as their complexes. In particular, we successfully developed novel methods for detailed analyses of dynamic interactions between glycolipid clusters and proteins associated with neurodegenerative disorders and dynamics of tertiary and quaternary structures of protein complexes involved in protein?fate determinations in cells. By applying the methods developed, we elucidated relationships between conformational fluctuations and functions of biomolecules.