|Budget Amount *help
¥72,020,000 (Direct Cost: ¥55,400,000、Indirect Cost: ¥16,620,000)
Fiscal Year 2012: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2010: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
The research program which aims to construct a theory to describe the molecular recognition process correlated with the structural fluctuation of protein was carried out along the four subjects listed below, and the goal of the research program was successfully achieved.
1. Statistical mechanics theory of molecular recognition (Equilibrium theory)
2. Application of the statistical mechanics of molecular recognition to "drug design"
3. Quasi dynamics of protein in solution based on the 3D-RISM and the molecular dynamics simulation
4. A new theory for structural fluctuation of protein, created by combining the 3D-RISM/RISM with the generalized Langevin theories