|Budget Amount *help
¥89,310,000 (Direct Cost : ¥68,700,000、Indirect Cost : ¥20,610,000)
Fiscal Year 2012 : ¥15,990,000 (Direct Cost : ¥12,300,000、Indirect Cost : ¥3,690,000)
Fiscal Year 2011 : ¥15,990,000 (Direct Cost : ¥12,300,000、Indirect Cost : ¥3,690,000)
Fiscal Year 2010 : ¥17,030,000 (Direct Cost : ¥13,100,000、Indirect Cost : ¥3,930,000)
Fiscal Year 2009 : ¥18,200,000 (Direct Cost : ¥14,000,000、Indirect Cost : ¥4,200,000)
Fiscal Year 2008 : ¥22,100,000 (Direct Cost : ¥17,000,000、Indirect Cost : ¥5,100,000)
The molecular chaperone is an important concept that connects a molecular-level biological process, protein folding, to cellular-level biological processes. In this project, we studied physicochemical relationships between structural fluctuations and functional expression of the chaperonin complexes. To elucidate how the biological functions utilize the structural fluctuations of the complexes, we investigated hydrogen/deuterium (H/D)-exchange reactions of the GroES portion of various chaperonin complexes by dimethylsulfoxide-quenched H/D-exchange two-dimensional NMR spectroscopy.