|Budget Amount *help
¥174,590,000 (Direct Cost: ¥134,300,000、Indirect Cost: ¥40,290,000)
Fiscal Year 2012: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2011: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2010: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2009: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2008: ¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Rab family small G proteins serve as molecular switches in the regulation of vesicle transport. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in higher neuronal functions. As to Rab3A, we found using the knockout mice for Rabconnectin, the Rab3A-related protein, is involved in neuronal function, probably through formation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neuronal extension. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in neurons.