| Budget Amount *help |
¥174,590,000 (Direct Cost: ¥134,300,000、Indirect Cost: ¥40,290,000)
Fiscal Year 2012: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2011: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2010: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2009: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2008: ¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
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| Research Abstract |
Defects in formation and transport of lysosome-related organelles (LROs) have been shown to cause human hereditary diseases, but the molecular mechanisms of their intracellular dynamics are poorly understood. In this study, we used melanosomes as a model for LROs and investigated their dynamics at the molecular level. We succeeded in identifying novel regulators that play a key role in melanosome biogenesis, matUration, and/or transport in melanocytes.
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