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Analysis of intracellular logistics by chemical biology

Planned Research

Project AreaIntracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic
Project/Area Number 20113008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKeio University (2010-2012)
The Institute of Physical and Chemical Research (2008-2009)

Principal Investigator

SIMIZU Siro  慶應義塾大学, 理工学部, 准教授 (30312268)

Co-Investigator(Kenkyū-buntansha) KONDOH Yasumitsu  独立行政法人理化学研究所, 専任研究員 (80333342)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥147,030,000 (Direct Cost: ¥113,100,000、Indirect Cost: ¥33,930,000)
Fiscal Year 2012: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2011: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2010: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Fiscal Year 2009: ¥28,730,000 (Direct Cost: ¥22,100,000、Indirect Cost: ¥6,630,000)
Fiscal Year 2008: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Keywordsケミカルバイオロジー / 化合物アレイ / 細胞内ロジスティクス / がん細胞の浸潤・転移 / がん細胞 / PDGF / ジスルフィド結合 / NF-κB / RelB / G3BP / VCP / 化合物バンク / Pirin / がん細胞遊走 / メラノーマ細胞 / 分化誘導 / 低分子化合物 / 公的化合物バンク施設 / 赤色蛍光タンパク質 / ヘパラナーゼ / NPDepo
Research Abstract

According to the request from a plan group member and a general invitation group member, chemical array and compound solution were used and it succeeded in acquisition of the interesting compounds.
Furthermore, TPh A which is the first Pirin inhibitor was able to be identified by the chemical array, and it was able to be shown clearly by using TPh A that Pirin is important for migration of melanoma cells.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (147 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (58 results) (of which Peer Reviewed: 54 results) Presentation (83 results) (of which Invited: 1 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Boronic acid inhibitors of acyl protein thioesterase 1 and 22013

    • Author(s)
      Zimmermann, T.J., Burger, M., Tashiro, E., Kondoh, Y., Martinez, N.E., Gormer, K., Rosin-steiner, S., Shimizu, T. Ozaki, S., Mikoshiba, K., Watanabe, N., Hall, D., Vetter, I.R., Osada, H., Hedberg, C., & Waldmann, H
    • Journal Title

      ChemBioChem

      Volume: 14 Issue: 1 Pages: 115-122

    • DOI

      10.1002/cbic.201200571

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput screening identifies small molecule inhibitors of molecular chaperones2013

    • Author(s)
      Kondoh, Y. & Osada, H
    • Journal Title

      Current Pharmaceutical Design

      Volume: 19 Pages: 473-492

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22920900

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013

    • Author(s)
      Ogasawara, A., Simizu, S., Ito, A., Kawai, T., Saisho, Y., Takei, I. & Umezawa, K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: (掲載決定) Issue: 2 Pages: 181-187

    • DOI

      10.1016/j.bbrc.2013.02.062

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013

    • Author(s)
      Arai, Y., Iinuma, H., Ikeda, Y., Igarashi, M., Hatano, M., Kinoshita, N., Ukaji, T., Simizu, S. & Umezawa, K
    • Journal Title

      The Journal of Antibiotics

      Volume: (掲載決定) Issue: 4 Pages: 225-230

    • DOI

      10.1038/ja.2012.112

    • NAID

      10031168683

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of cathepsin V activity and intracellular trafficking by N-glycosylation2012

    • Author(s)
      Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S
    • Journal Title

      FEBS Letters

      Volume: 586 Issue: 20 Pages: 3601-3607

    • DOI

      10.1016/j.febslet.2012.08.001

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia2012

    • Author(s)
      Niwa, Y., Matsui, C., Sukumwang, N., Iinuma, H., Ikeda, Y., Koyano, T., Kovitayakorn, T., Simizu, S. & Umezawa, K
    • Journal Title

      Planta Medica

      Volume: 78 Issue: 10 Pages: 957-961

    • DOI

      10.1055/s-0031-1298538

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012

    • Author(s)
      Yasukagawa, T., Niwa, Y., Simizu, S. & Umezawa, K
    • Journal Title

      FEBS Letters

      Volume: 586 Issue: 10 Pages: 1504-1509

    • DOI

      10.1016/j.febslet.2012.04.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced brest cancer cell adhesion2012

    • Author(s)
      Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 2080-2084

    • DOI

      10.3892/or.2012.1733

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-92012

    • Author(s)
      Khan, M. G. M., Simizu, S., Suzuki, T., Masuda, A., Muroi, M., Kawatani, M., Dohmae, N. & Osada, H
    • Journal Title

      Experimental Cell Research

      Volume: 318 Issue: 8 Pages: 904-914

    • DOI

      10.1016/j.yexcr.2012.02.021

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      Takeiri, M., Horie, K., Takahashi, D., Watanabe, M., Horie, R., Simizu, S. & Umezawa, K
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 10 Issue: 15 Pages: 3053-3059

    • DOI

      10.1039/c2ob07104e

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases2012

    • Author(s)
      Burger, M., Zimmermann, T. J., Kondoh, Y., Stege, P., Watanabe, N., Osada, H., Waldmann, H. & Vetter, I. R
    • Journal Title

      Journal of Lipid Research

      Volume: 53 Issue: 1 Pages: 43-50

    • DOI

      10.1194/jlr.m019851

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein2012

    • Author(s)
      Sasazawa, Y., Kanagaki, S., Tashiro, E., Nogawa, T., Muroi, M., Kondoh, Y., Osada, H., Imoto, M
    • Journal Title

      ACS Chemical Biology

      Volume: (in press) Issue: 5 Pages: 892-900

    • DOI

      10.1021/cb200492h

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-92012

    • Author(s)
      Khan, MGM., et al.
    • Journal Title

      Experimental Cell Research

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion2012

    • Author(s)
      Noma, N., et al.
    • Journal Title

      Oncology Reports

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity in spite of close relationship to acyl protein thioesterases2012

    • Author(s)
      Burger, M., et al.
    • Journal Title

      Journal of lipid research

      Volume: 53 Pages: 43-50

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein2012

    • Author(s)
      Sasazawa, Y., et al.
    • Journal Title

      ACS Chemical Biology

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity2011

    • Author(s)
      Minagawa, S., Kondoh, Y., Sueoka, K., Osada, H. & Nakamoto, H
    • Journal Title

      Biochemical Journal

      Volume: 435 Issue: 1 Pages: 237-246

    • DOI

      10.1042/bj20100743

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure2011

    • Author(s)
      Hirai, G., Tsuchiya, A., Koyama, Y., Otani, Y., Oonuma, K., Dodo, K., Simizu, S., Osada, H. & Sodeoka, M
    • Journal Title

      ChemMedChem

      Volume: 6 Issue: 4 Pages: 617-622

    • DOI

      10.1002/cmdc.201100107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp1202011

    • Author(s)
      Khan, M. G. M., Simizu, S., Lai, N. S., Kawatani, M., Shimizu, T. & Osada, H
    • Journal Title

      ACS Chemical Biology

      Volume: 6 Issue: 3 Pages: 245-251

    • DOI

      10.1021/cb100387r

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The potential of protein disulfide isomerase as a therapeutic drug target2011

    • Author(s)
      Khan, MGM., et al.
    • Journal Title

      Oncology Research

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.2011

    • Author(s)
      Khan, M.G.M., Simizu, S., Lai, N.S., Kawatani, M., Shimizu, T., Osada, H.
    • Journal Title

      ACS Chem.Biol. 6

      Pages: 245-251

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity.2011

    • Author(s)
      Minagawa, S., et al.
    • Journal Title

      Biochemical Journal

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.2011

    • Author(s)
      Khan, M.G.M., et al.
    • Journal Title

      ACS Chemical Biology

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a vaccinia H1-related (VHR) phosphatase inhibitor with non-acidic-phosphate-mimic core structure.2011

    • Author(s)
      Hirai, G., et al.
    • Journal Title

      ChemMedChem

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小分子化合物TPhAを用いた初のピリン機能解明2011

    • Author(s)
      宮崎功, 他
    • Journal Title

      実験医学

      Volume: 29 Pages: 79-83

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 化合物アレイを起点としたケミカルバイオロジー化合物アレイの基盤技術開発から機能未知タンパク質の機能解析まで2011

    • Author(s)
      叶直樹、清水史郎
    • Journal Title

      化学と工業

      Volume: 64 Pages: 37-39

    • NAID

      10027655880

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays2010

    • Author(s)
      Hagiwara, K., Kondoh, Y., Ueda, A., Yamada, K., Goto, H., Watanabe, T., Nakata, T., Osada, H. & Aida, Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 394 Issue: 3 Pages: 721-727

    • DOI

      10.1016/j.bbrc.2010.03.058

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array2010

    • Author(s)
      Hagiwara, K., Murakami, T., Xue, G., Shimizu, Y., Takeda, E., Hashimoto, Y., Honda, K., Kondoh, Y., Osada, H., Tsunetsugu-Yokota, Y. & Aida, Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Issue: 1 Pages: 40-45

    • DOI

      10.1016/j.bbrc.2010.10.107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion2010

    • Author(s)
      Miyanishi, N., Suzuki, Y., Simizu, S., Kuwabara, Y., Banno, K. & Umezawa, K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Issue: 1 Pages: 154-159

    • DOI

      10.1016/j.bbrc.2010.11.007

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells2010

    • Author(s)
      Miyazaki, I., Simizu, S., Okumura, H., Takagi, S. & Osada, H
    • Journal Title

      Nature Chemical Biology

      Volume: 6 Issue: 9 Pages: 667-673

    • DOI

      10.1038/nchembio.423

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix2010

    • Author(s)
      Kanoh, N., Takayama, H., Honda, K., Moriya, T., Teruya, T., Simizu, S., Osada, H. & Iwabuchi, Y
    • Journal Title

      Bioconjugate Chemistry

      Volume: 21 Issue: 1 Pages: 182-186

    • DOI

      10.1021/bc900316q

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.2010

    • Author(s)
      Miyazaki, I., Simizu, S., Okumura, H., Takagi, S., Osada, H.
    • Journal Title

      Nature Chem.Biol. 6

      Pages: 667-673

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.2010

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      Nature Chemical Biology

      Volume: 6 Pages: 667-673

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays.2010

    • Author(s)
      Hagiwara, K., et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 394 Pages: 721-727

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array.2010

    • Author(s)
      Hagiwara, K., et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Pages: 40-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma Cell invasion.2010

    • Author(s)
      Miyanishi, N., et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Pages: 154-159

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix2010

    • Author(s)
      Kanoh, N., et al.
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The application of the chemical array for biological study2010

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      Methods Mol.Biol. (印刷中)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009

    • Author(s)
      Simizu, S., Teruya, T., Nogawa, T., Aono, H., Ueki, M., Uramoto, M., Kobayashi, Y. & Osada, H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 383 Issue: 4 Pages: 406-410

    • DOI

      10.1016/j.bbrc.2009.04.014

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors2009

    • Author(s)
      Miyazaki, I., Simizu, S., Ishida, K. & Osada, H
    • Journal Title

      ChemBioChem

      Volume: 10 Issue: 5 Pages: 838-843

    • DOI

      10.1002/cbic.200800704

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array2009

    • Author(s)
      Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y. & Osada, H
    • Journal Title

      ChemBioChem

      Volume: 10 Issue: 5 Pages: 845-852

    • DOI

      10.1002/cbic.200800728

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription2009

    • Author(s)
      Takagi, S., Simizu, S. & Osada, H
    • Journal Title

      Cancer Research

      Volume: 69 Issue: 4 Pages: 1502-1508

    • DOI

      10.1158/0008-5472.can-08-2635

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway2009

    • Author(s)
      Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T. & Osada, H
    • Journal Title

      Journal of Antibiotics

      Volume: 62 Issue: 2 Pages: 105-107

    • DOI

      10.1038/ja.2008.17

    • NAID

      10030634719

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis2009

    • Author(s)
      Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N. & Osada, H
    • Journal Title

      Oncogene

      Volume: 28 Issue: 1 Pages: 107-116

    • DOI

      10.1038/onc.2008.368

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009

    • Author(s)
      Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y., Osada, H.
    • Journal Title

      ChemBioChem 10

      Pages: 845-852

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009

    • Author(s)
      Takagi, S., Simizu, S., Osada, H.
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009

    • Author(s)
      Simizu, S., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 383

      Pages: 406-410

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.2009

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      ChemBioChem 10(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein using a chemical array.2009

    • Author(s)
      Miyazaki, I., et al.
    • Journal Title

      ChemBioChem 10(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009

    • Author(s)
      Takagi, S., et al.
    • Journal Title

      Cancer Research 69

      Pages: 1502-1508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway.2009

    • Author(s)
      Asami Y., et al.
    • Journal Title

      Journal of Antibiotics 62(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009

    • Author(s)
      Tamura Y, et al.
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II2008

    • Author(s)
      Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M. & Osada, H
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 72 Pages: 2739-2749

    • NAID

      10027533381

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/18838795

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase2008

    • Author(s)
      Lai, N. S., Simizu, S., Morisaki, D., Muroi, M. & Osada, H
    • Journal Title

      Experimental Cell Research

      Volume: 314 Issue: 15 Pages: 2834-2845

    • DOI

      10.1016/j.yexcr.2008.07.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library:identification of novel inhibitors of carbonic anhydrase II.2008

    • Author(s)
      Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M., Osada, H.
    • Journal Title

      Biosci.Biotechnol.Biochem. 72

      Pages: 2739-2749

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.2008

    • Author(s)
      Lai, N. S., et al.
    • Journal Title

      Experimental Cell Research 314

      Pages: 2834-2845

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II.2008

    • Author(s)
      Miyazaki, I.., et al.
    • Journal Title

      Bioscience,Biotechnology,and Biochemistry 72

      Pages: 2739-2749

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子細胞学的解析2008

    • Author(s)
      清水 史郎 他
    • Journal Title

      日本臨牀 増刊号1 がん薬物療法学 67

      Pages: 143-147

    • Related Report
      2008 Annual Research Report
  • [Presentation] 低分子マイクロアレイを用いたMDM2/MDMX-p53阻害剤の探索法の開発2013

    • Author(s)
      野口 太朗、他
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 低分子マイクロアレイを用いたMDM2/MDMX-p53阻害剤の探索法の開発2013

    • Author(s)
      野口 太朗、他
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化合物アレイによるヘッジホッグ伝達経路の阻害剤の探索2013

    • Author(s)
      近藤 恭光、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス、宮城県
    • Year and Date
      2013-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] がん細胞にアポトーシスを誘導するアセトアミド誘導体の活性評価と作用機序解析2013

    • Author(s)
      河村 達郎、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス、宮城県
    • Year and Date
      2013-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Pyrrocidine Aによるミトコンドリアを介したアポトーシス誘導機構2013

    • Author(s)
      上杉 祥太、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス、宮城県
    • Year and Date
      2013-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 化合物アレイによるヘッジホッグ伝達経路の阻害剤の探索2013

    • Author(s)
      近藤 恭光、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん細胞にアポトーシスを誘導するアセトアミド誘導体の活性評価と作用機序解析2013

    • Author(s)
      河村 達郎、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pyrrocidine Aによるミトコンドリアを介したアポトーシス誘導機構2013

    • Author(s)
      上杉 祥太、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 植物ホルモン・アブシジン酸の新規アゴニスト・アンタゴニスト探索2013

    • Author(s)
      伊藤 卓也、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス、宮城県
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 植物ホルモン・アブシジン酸の新規アゴニスト・アンタゴニスト探索2013

    • Author(s)
      伊藤 卓也、他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013

    • Author(s)
      Simizu, S., et al.
    • Organizer
      9th AACR-JCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui、アメリカ
    • Year and Date
      2013-02-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013

    • Author(s)
      Simizu, S., et al.
    • Organizer
      9th AACR-JCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui(アメリカ)
    • Year and Date
      2013-02-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化合物アレイによるアミノ酸置換変異体特異的阻害剤の探索手法の開発2012

    • Author(s)
      近藤 恭光、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場他、福岡県
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 化合物アレイによるアミノ酸置換変異体特異的阻害剤の探索手法の開発2012

    • Author(s)
      近藤 恭光、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、他
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] LAP結合TGF-β活性化反応阻害物質の探索2012

    • Author(s)
      山本 由佳、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場他、福岡県
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] LAP結合TGF-β活性化反応阻害物質の探索2012

    • Author(s)
      山本 由佳、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、他
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] p38のゲートキーパーの多様性を標的とした特異的阻害剤探索2012

    • Author(s)
      須藤 龍彦、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場他、福岡県
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] オートファジーを制御する低分子化合物の探索2012

    • Author(s)
      三好 良幣、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場他、福岡県
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] p38のゲートキーパーの多様性を標的とした特異的阻害剤探索2012

    • Author(s)
      須藤 龍彦、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、他
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] オートファジーを制御する低分子化合物の探索2012

    • Author(s)
      三好 良幣、他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、他
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] LAP結合TGF-β活性化反応阻害物質の探索2012

    • Author(s)
      山本 由佳、他
    • Organizer
      第26回肝類洞壁細胞研究会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル宇部、山口県
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] LAP結合TGF-β活性化反応阻害物質の探索2012

    • Author(s)
      山本 由佳、他
    • Organizer
      第26回肝類洞壁細胞研究会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル宇部(山口県)
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of hyaluronidase1 enzymatic activity by C-mannosylation2012

    • Author(s)
      Goto, Y., et al.
    • Organizer
      EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Convention Centre Dublin、アイルランド
    • Year and Date
      2012-11-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of hyaluronidase1 enzymatic activity by C-mannosylation2012

    • Author(s)
      Goto, Y., et al.
    • Organizer
      EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Convention Centre Dublin(アイルランド)
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血漿カリクレイン依存的TGF-β活性化反応阻害剤の探索2012

    • Author(s)
      坂田 幸大郎、他
    • Organizer
      第23回日本レチノイド研究会
    • Place of Presentation
      米子コンベンションセンター、鳥取県
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 血漿カリクレイン依存的TGF-β活性化反応阻害剤の探索2012

    • Author(s)
      坂田 幸大郎、他
    • Organizer
      第23回日本レチノイド研究会
    • Place of Presentation
      米子コンベンションセンター(鳥取県)
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Induction of RelB degradation and apoptosis in adult T-cell leukemia cells by DTCM-glutarimide2012

    • Author(s)
      伊藤あゆみ、他
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌他、北海道
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Induction of RelB degradation and apoptosis in adult T-cell leukemia cells by DTCM-glutarimide2012

    • Author(s)
      伊藤あゆみ、他
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌、他(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of C-mannosylation on hyaluronidase1 functions2012

    • Author(s)
      後藤祐貴、他
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌他、北海道
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of C-mannosylation on hyaluronidase1 functions2012

    • Author(s)
      後藤祐貴、他
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌、他(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] N-glycosylation regulates cathepsin L2 functions2012

    • Author(s)
      Niwa, Y., et al.
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Brisbane Convention Centre & Exhibition Centre、オーストラリア
    • Year and Date
      2012-09-04
    • Related Report
      2012 Final Research Report
  • [Presentation] N-glycosylation regulates cathepsin L2 functions2012

    • Author(s)
      Niwa, Y., et al.
    • Organizer
      The 14th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Brisbane Convention Centre & Exhibition Centre(オーストラリア)
    • Year and Date
      2012-09-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] カテプシンL2の機能に与えるN-glycosylationの役割2012

    • Author(s)
      丹羽祐貴、他
    • Organizer
      第21回 日本がん転移学会学術集会・総会
    • Place of Presentation
      オリエンタルホテル広島、広島県
    • Year and Date
      2012-07-13
    • Related Report
      2012 Final Research Report
  • [Presentation] がん分子標的研究の今昔2012

    • Author(s)
      清水史郎
    • Organizer
      理研セミナー
    • Place of Presentation
      理化学研究所、埼玉県
    • Year and Date
      2012-07-13
    • Related Report
      2012 Final Research Report
  • [Presentation] カテプシンL2の機能に与えるN-glycosylationの役割2012

    • Author(s)
      丹羽祐貴、他
    • Organizer
      第21回 日本がん転移学会学術集会・総会
    • Place of Presentation
      オリエンタルホテル広島(広島県)
    • Year and Date
      2012-07-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん分子標的研究の今昔2012

    • Author(s)
      清水史郎
    • Organizer
      理研セミナー
    • Place of Presentation
      理化学研究所(埼玉県)
    • Year and Date
      2012-07-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 植物性アルカロイドconophyllineによる癌細胞薬剤耐性の軽減と標的タンパク質の結合解析2012

    • Author(s)
      舟崎慎太郎、他
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      西日本総合展示場、福岡県
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 植物性アルカロイドconophyllineによる癌細胞薬剤耐性の軽減と標的タンパク質の結合解析2012

    • Author(s)
      舟崎慎太郎、他
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      西日本総合展示場(福岡県)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 免疫抑制剤デオキシスパーガリンの標的分子の探索2012

    • Author(s)
      村橋将崇、他
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都大学、京都府
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 免疫抑制剤デオキシスパーガリンの標的分子の探索2012

    • Author(s)
      村橋将崇、他
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-06-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Spectomycin B1 suppresses Estrogen Receptor α-Dependent Breast Cancer Cell Growth by inhibiting a SUMO E2 Activity2012

    • Author(s)
      Ito Akihiro、他
    • Organizer
      2nd SNU-RIKEN Joint Symposium on Chemical Biology
    • Place of Presentation
      Naminara Hotel、大韓民国
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Screening of Chemical Regulators for TGF-β Activation Reaction2012

    • Author(s)
      Sakata Kotaro、他
    • Organizer
      2nd SNU-RIKEN Joint Symposium on Chemical Biology
    • Place of Presentation
      Naminara Hotel、大韓民国
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Spectomycin B1 suppresses Estrogen Receptor α-Dependent Breast Cancer Cell Growth by inhibiting a SUMO E2 Activity2012

    • Author(s)
      Ito, A., et al.
    • Organizer
      2nd SNU-RIKEN Joint Symposium on Chemical Biology
    • Place of Presentation
      Naminara Hotel(大韓民国)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Screening of Chemical Regulators for TGF-β Activation Reaction2012

    • Author(s)
      Sakata, K., et al.
    • Organizer
      2nd SNU-RIKEN Joint Symposium on Chemical Biology
    • Place of Presentation
      Naminara Hotel(大韓民国)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] p38γおよびp38δ特異的阻害剤探索のための化合物アレイの改良2012

    • Author(s)
      近藤恭光, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学:京都
    • Year and Date
      2012-03-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞周期G2/M期に作用する小分子化合物の構造活性相関研究2012

    • Author(s)
      高木隆吉, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学:京都
    • Year and Date
      2012-03-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Xanthohumolのautophagy制御機構解析2012

    • Author(s)
      金墻周平, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学:京都
    • Year and Date
      2012-03-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Discovery of spectomycin B1 as a SUMO E2 inhibitor2012

    • Author(s)
      Ito A., et al.
    • Organizer
      The 6th Japan-Korea Chemical Biology Symposium
    • Place of Presentation
      定山渓温泉花もみじ:北海道
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] TGF-β活性化反応阻害物質のケミカルスクリーニング2011

    • Author(s)
      山本由佳, 他
    • Organizer
      第25回肝類洞壁細胞研究会学術集会
    • Place of Presentation
      東京ガーデンパレス:東京
    • Year and Date
      2011-12-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] TGF-β活性化反応阻害物質のケミカルスクリーニング2011

    • Author(s)
      山本由佳, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜:神奈川
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝細胞癌再発抑制剤「非環式レチノイド」の作用標的分子同定の試み2011

    • Author(s)
      辰川英樹, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜:神奈川
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Vpr Helix3領域と結合する新規HIV-1阻害剤の開発2011

    • Author(s)
      萩原恭二, 他
    • Organizer
      第25回日本エイズ学会学術集会・総会
    • Place of Presentation
      ハイアットリージェンシー東京:東京
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン酸化RXRα特異抗体の作製および非環式レチノイドの標的分子同定の試み2011

    • Author(s)
      辰川英樹, 他
    • Organizer
      日本レチノイド研究会学術集会
    • Place of Presentation
      日本大学会館:東京
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Screening of novel regulators targeting TGF-β activation reaction2011

    • Author(s)
      Sakata, K., et al.
    • Organizer
      2011 RIKEN Chemical Biology Symposium, Next Generation Tools for Molecular Target Discovery
    • Place of Presentation
      理化学研究所:埼玉
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of melanoma cell migration by Pirin revealed by an approach of chemical biology2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場:名古屋(招待講演)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 植物寄生糸状菌が産生する新規pyrrocidine類の抗癌活性メカニズムについて2011

    • Author(s)
      上杉祥太, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館:京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ケミカルバイオロジーと細胞内ロジスティクス研究の融合2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館:京都(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Protein disulfide isomeraseによるMMP-9の活性化機構の解析2011

    • Author(s)
      清水史郎
    • Organizer
      第20回日本がん転移学会学術集会
    • Place of Presentation
      アクトシティ浜松:浜松
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Galectin-3 binding proteinの作用と発現におけるNF-κBの関与2011

    • Author(s)
      野間成人, 他
    • Organizer
      第15回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテル日航東京:東京
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Protein disulfide isomerase-mediated disulfide bonds regulate the activation and secretion of matrix metalloproteinase-92011

    • Author(s)
      Khan, MGM, 他
    • Organizer
      第15回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテル日航東京:東京
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 化合物アレイを用いたタンパク質阻害剤の網羅的探索2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 化合物アレイを用いたタンパク質阻害剤の網羅的探索2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      ツインメッセ静岡、静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化合物アレイによるNPを標的にした抗インフルエンザ薬の探索2011

    • Author(s)
      近藤恭光, 他
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都女子大学、京都
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIV-1 Vprを標的とした新規抗ウイルス薬のスクリーニングと作用機序解析2010

    • Author(s)
      村上知行, 他
    • Organizer
      第24回日本エイズ学会学術集会・総会
    • Place of Presentation
      ザ・プリンスさくらタワー東京、東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of an inhibitor for melanoma cell migration through the inhibition of Pirin2010

    • Author(s)
      Miyazaki, I., et al.
    • Organizer
      22nd EORTC-NCI-AACR symposium on "Molecular targets and Cancer Therapeutics"
    • Place of Presentation
      ESTREL hotel and Convention Centre, Berlin
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗2型糖尿病薬カリウムチャネル阻害剤による癌細胞の浸潤抑制2010

    • Author(s)
      安ヶ川たまみ, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場:大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protein disulfide isomerase阻害剤の探索とNPD281による阻害2010

    • Author(s)
      カーンモハマッドゴーラムマオラ, 他
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      タワーホール船堀:東京
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規低酸素誘導因子(HIF)阻害剤の創薬研究2010

    • Author(s)
      大槻さつき, 他
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      タワーホール船堀:東京
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化合物アレイを用いたPirin阻害剤の探索と解析2010

    • Author(s)
      宮崎功, 他
    • Organizer
      第14回日本がん分子標的治療学会学術集会
    • Place of Presentation
      タワーホール船堀:東京
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pirin によるメラノーマ細胞の遊走制御と阻害剤探索2010

    • Author(s)
      清水史郎
    • Organizer
      第19回日本がん転移学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2010-06-16
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Pirinによるメラノーマ細胞の遊走制御と阻害剤探索2010

    • Author(s)
      清水史郎
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール:金沢市
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration2009

    • Author(s)
      宮崎功, et al.
    • Organizer
      AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      米国ボストン : John B.Hynes Veterans Memorial Convention Center
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009

    • Author(s)
      清水史郎、宮崎功、長田裕之
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009

    • Author(s)
      清水史郎, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜:横浜市
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fragment-based approach for new tool of inhibitor design2009

    • Author(s)
      宮崎功, et al.
    • Organizer
      The 25th Naito Conference on Chemical Biology[II]
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ:札幌市
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化合物アレイを用いた抗がん剤スクリーニング系の開発2009

    • Author(s)
      清水史郎, 他
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島:徳島市
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規抗癌剤スクリーニング法の開発:化合物アレイを用いたフラグメントベースデザイン2009

    • Author(s)
      宮崎功, 他
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島:徳島市
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009

    • Author(s)
      清水史郎、宮崎功、長田裕之
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009

    • Author(s)
      清水史郎, 他
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島:徳島市
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Establishment of novel antitumor drugsscreening method by using chemical array2009

    • Author(s)
      Simizu, S., Miyazaki, I., Osada, H.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      アメリカ・ニューオリンズ
    • Year and Date
      2009-02-09
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009

    • Author(s)
      Simizu, S., et al.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      米国 : Westin New Orleans Canal Place
    • Related Report
      2008 Annual Research Report
  • [Presentation] On-chip fragment-based approach for new tool of antitumor drug design2009

    • Author(s)
      Miyazaki, I., et al.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      米国 : Westin New Orleans Canal Place
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activation and function of heparanase: roles of post-translational modifications2008

    • Author(s)
      Simizu, S., et al.
    • Organizer
      International Symposium on Systems Glycobiology
    • Place of Presentation
      東京 : 東京カンファレンスセンター
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Book] がん分子標的治療研究ハンドブック2009

    • Author(s)
      清水史郎、宮崎功、本田香織、近藤恭光、長田裕之
    • Publisher
      金芳堂
    • Related Report
      2010 Self-evaluation Report
  • [Book] がんの分子標的治療2008

    • Author(s)
      清水史郎、長田裕之
    • Publisher
      南山堂
    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.applc.keio.ac.jp/~simizu/

    • Related Report
      2012 Final Research Report
  • [Remarks] 慶應義塾大学・理工学部・応用化学科・生物化学研究室

    • URL

      http://www.applc.keio.ac.jp/~simizu/

    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.applc.keio.ac.jp/~umezawa/

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 宮崎功、清水史郎、長田裕之「タンパク質の機能を明らかにする小分子化合物」ライフサイエンス「新着論文レビュー」(2010).

    • URL

      http://first.lifesciencedb.jp/archives/907

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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