|Budget Amount *help
¥220,480,000 (Direct Cost: ¥169,600,000、Indirect Cost: ¥50,880,000)
Fiscal Year 2012: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000)
Fiscal Year 2011: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2010: ¥45,630,000 (Direct Cost: ¥35,100,000、Indirect Cost: ¥10,530,000)
Fiscal Year 2009: ¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2008: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
The aim of this study is to elucidate the nature of mouse GSC (spermatogenic stem cells), as well as their niche and niche cells. By using originally developed experimental systems, we have investigated the behavior of stem spermatogonia in undisturbed testes. (1) Discovery of hierarchy and reversibility within the stem cell compartment, (2) discovery of frequent loss and replacement of stem cells, and (3) elucidation of the GSC dynamics at a single cell resolution together lead us to propose a model that would challenge the prevailing theory that wasproposed in 1971.