|Budget Amount *help
¥113,880,000 (Direct Cost: ¥87,600,000、Indirect Cost: ¥26,280,000)
Fiscal Year 2012: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2011: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2010: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2008: ¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Asexual planarians of Dugesia ryukyuensis can develop the hermaphroditic reproductive organs, if they are fed with sexual planarians of the different as well as the same species; this means that they contain sex-inducing substances that are not species-specific. The sex-inducing substances may induce the gamete stem cells/niche system from the pluripotent stem cells called neoblasts. In this study, we established the molecular basis for understanding the mechanism underlying regulation of gamete stem cells/niche system in the planarian ovary. Otherwise, we obtained a more purified fraction including D-Trp with a strong sex-inducing activity. D-Trp, which has been identified as an ovarian inducing substance, may give rise to a strong sex-inducing activity with the substances containing in the fraction.