| Budget Amount *help |
¥118,040,000 (Direct Cost: ¥90,800,000、Indirect Cost: ¥27,240,000)
Fiscal Year 2012: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2011: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2010: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2009: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2008: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
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| Research Abstract |
Although ATP is essential for cell survival, efficient synthesis of ATP results in generation of reactive oxygen species (ROS) as inevitable deleterious by-products. ROS is highly reactive and thus induces cell and tissue damage; on the other hand, increasing attention has currently been paid to beneficial roles of ROS. For this purpose, there exist enzymes dedicated to ROS production, such as Nox family NADPH oxidases. In the present study, we have intensively studied ROS production by various types of Nox oxidases and clarified molecular mechanisms for Nox regulation.
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