|Budget Amount *help
¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
This study is aimed at elucidating the molecular mechanism of extremophilic proteins that bind and hydrolyze ATP and its related compounds. Specifically, biochemical and biophysical experimentations have been carried out using ATPase and its related proteins from extremophies living in high salt concentrations and high and low temperatures, which seem to affect on the hydration conditions. In addition, collaborating with theoretical teams, molecular mechanisms for ATP binding and hydrolysis were investigated in the aspects of hydration. As a result, protein mechanisms have been clarified through ATP hydrolyzing proteins from halophiles and thermophiles.