|Budget Amount *help
¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Water is a origin of life and various biomolecules like myosin which induces muscle contraction emerge functions in water environment. It is known that Myosin converts chemical energy of ATP into mechanical work, however, the role of water in the conversion mechanism was unclear. Here, we observed elementary mechanical processes of myosin in action in the presence of osmolyte. we found entropic potential field of water molecules formed for a actomyosin interface regulates binding force between myosin and actin. Further, hydration/dehydration dynamics around actomyosin affected force generation. We suggest water explicitly play an important role in the force generation in terms of energy conversion.