| Budget Amount *help |
¥138,060,000 (Direct Cost: ¥106,200,000、Indirect Cost: ¥31,860,000)
Fiscal Year 2024: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2023: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2022: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2021: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2020: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
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| Outline of Final Research Achievements |
This study explored weak physicochemical interactions at interfaces between cells and materials such as viruses, metal ions, and biomimetic substances. Using live-cell fluorescence imaging, we visualized how subtle stimuli induce structural and functional changes in cells. Key findings include: (1) intercellular calcium wave propagation (iCWP) triggered by influenza virus infection, which promotes viral spread to surrounding cells; (2) transient cell contraction and inhibition of endocytosis upon extracellular magnesium stimulation via actin remodeling; and (3) discovery of Rab5/Rab7 double-positive vesicles (“duosomes”), a non-canonical endosomal intermediate. These findings refine models of signal transduction and membrane trafficking, and offer insights into how weak external cues shape cell behavior. This work enhances understanding of cell-material interactions and contributes to infection control, drug delivery, and development of symbiotic materials.
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