| Budget Amount *help |
¥103,220,000 (Direct Cost: ¥79,400,000、Indirect Cost: ¥23,820,000)
Fiscal Year 2024: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2023: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2022: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2021: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2020: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
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| Outline of Final Research Achievements |
This study aimed to elucidate the molecular and cellular mechanisms of inflammation control in the liver using advanced techniques such as intravital multiphoton imaging, laser ablation, and spatiotemporal single-cell analysis. The researchers identified a novel anti-inflammatory macrophage (MP2) localized around the portal vein and clarified its molecular characteristics and dependence on gut microbiota. Furthermore, they discovered neuron-associated macrophages (pNAMs) closely linked to sympathetic nerves, which contribute to the construction of the periportal sympathetic nerve network and regulate vascular permeability and immune tolerance within the liver. These findings reveal the essence of liver-specific immune regulation and propose new therapeutic targets for liver diseases.
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