Whole-brain imaging in single-cell resolution visualizes Glia function in sleep-wake cycle

• Project Area: Glia decoding: deciphering information critical for brain-body interactions
• Project/Area Number: 20H05903
• Research Category: Grant-in-Aid for Transformative Research Areas (A)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: University of Tsukuba (2022); The University of Tokyo (2020-2021)
• Principal Investigator: 史 蕭逸 筑波大学, 国際統合睡眠医科学研究機構, 助教 (40803656)
• Co-Investigator(Kenkyū-buntansha): 戸根 大輔 東京大学, 大学院医学系研究科(医学部), 助教 (60806610)
• Project Period (FY): 2020-11-19 – 2025-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥103,220,000 (Direct Cost: ¥79,400,000、Indirect Cost: ¥23,820,000); Fiscal Year 2022: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2021: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2020: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
• Keywords: 睡眠 / グリア細胞 / グリア / 透明化 / イメージング / 全脳透明化

Outline of Research at the Start

全脳1細胞解像度のグリア細胞解析技術を開発し、睡眠覚醒サイクルにおけるグリア細胞の役割を明らかにする。