|Budget Amount *help
¥56,810,000 (Direct Cost: ¥43,700,000、Indirect Cost: ¥13,110,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2012: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2009: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
We developed the time integration of electrochemical and chemical reactions using the cation pool method, and applied it to the synthesis of functional materials such as dendritic molecules. The space integration of cationic reactions using flow microreactors was also achieved, and new transformations such as cationic three-component coupling reactions were developed. The space integration of anionic species was also achieved. We showed that a flow microreactor enables the generation and reactions of highly unstable organolithium species such as aryllithium species bearing ketone carbonyl groups. The method was successfully applied to the formal synthesis of a natural product. We also showed that flow microreactors allow generation and use of configurationally unstable chiral organolithium species.
In summary, we developed various transformations that are difficult to achieve by conventional methods based on reaction integration via short-lived, highly reactive ionic species.