|Budget Amount *help
¥131,560,000 (Direct Cost: ¥101,200,000、Indirect Cost: ¥30,360,000)
Fiscal Year 2013: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2012: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2011: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2010: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2009: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Current research project demonstrates biological importance of long noncoding RNA by genetic approaches using fruit flies and mice. Mutational studies showed that 1) high-molecular weight long noncoding RNA plays an impotent role in formation of neural circuits in the adult fly brain and 2) RNA binding protein hnRNP U, which carries both an RNA binding domain and a chromatin binding domain, is essential for localization of Xist RNA, an essential component in dosage compensation in mammals. In the course of study, we found that some of the putative long noncoding RNA include short ORFs that encodes extremely small peptides and those peptides, at least in some cases, regulate gene expression in transcriptional network.