|Budget Amount *help
¥151,970,000 (Direct Cost: ¥116,900,000、Indirect Cost: ¥35,070,000)
Fiscal Year 2013: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2012: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Fiscal Year 2011: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2010: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2009: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
In the very early stages of the mammalian embryogenesis (8 to 32 cells), the establishment of epithelial polarity in the outer cells of the cell mass is crucially important to guarantee the gradual fixation of the fates of the individual cells. Based on the fact that dynamic change of the epithelial cell polarity is crucially important for the mammalian embryonic development, in this research project, we have intensively analyzed the mechanisms by which the evolutionarily-conserved cell polarity-regulating proteins, the PAR-aPKC proteins, control the epithelial polarity. As a result, we succeeded to reveal three kinds of the novel molecular mechanisms, and provided the important insights and basis for the future research on the early embryogenesis of mammals.