環境連成力学を基盤とした微生物行動シミュレータの開発

• Project Area: Advanced mechanics of cell behavior shapes formal algorithm of protozoan smartness awoken in giorama conditions.
• Project/Area Number: 21H05308
• Research Category: Grant-in-Aid for Transformative Research Areas (A)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (IV)
• Research Institution: Tohoku University
• Principal Investigator: 石川 拓司 東北大学, 医工学研究科, 教授 (20313728)
• Co-Investigator(Kenkyū-buntansha): 上野 裕則 愛知教育大学, 教育学部, 准教授 (70518240) ; 西上 幸範 北海道大学, 電子科学研究所, 准教授 (80639021)
• Project Period (FY): 2021-09-10 – 2026-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥101,790,000 (Direct Cost: ¥78,300,000、Indirect Cost: ¥23,490,000); Fiscal Year 2025: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2024: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2023: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2022: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2021: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
• Keywords: 微生物 / 行動力学 / ジオラマ環境 / シミュレーション / 可視化計測

Outline of Research at the Start

本研究では、環境連成問題を徹底的に力学化して原生知能のアルゴリズムを読み解く。始めに、保存則を学理とした支配方程式を連立して解くことで、ジオラマ環境とパノラマ環境の物理量を詳細に求める。次に、細胞応答の数理モデル化を行い、個々の細胞の行動を計算する。最後に、細胞集団の行動を計算する「微生物行動シミュレータ」を開発する。開発したシミュレータを用い、密度成層内の有害赤潮藻の行動アルゴリズム、蠕動流れ中の腸内細菌の行動アルゴリズム、気液界面の微生物の行動アルゴリズムの３つの重要な生命現象を解明する。領域内の他班から実験データの提供を受け、自身は徹底力学化のインフラ的役割を担う。

Outline of Annual Research Achievements

本年度の主要な研究実績は以下の通りである。　１．ジオラマ環境における微小生物の行動に関するレビュー論文を、招待されてJournal of the Physical Society of Japan誌に発表した。　２．微生物の動きと行動に関するレビュー論文を、流体力学分野で最高峰のAnnual Review of Fluid Mechanics誌に招待されて発表した。　３．複雑環境下の微生物の挙動に関する２編のレビュー論文を、Journal of Biomechanics誌に招待されて発表した。　４．線虫が電場に応答して空中へ飛翔し、昆虫の足などに貼りつく行動を発見した。この成果はプレスリリースされ、生物学で定評のあるCurrent Biology誌に掲載された。　５．襟べん毛虫の群体が光刺激によって形態や行動を変化させるメカニズムを調べた。光が強く餌が多い場所では鞭毛を内向きにして摂食モードとなり、光が弱く餌が少ない場所では鞭毛を外向きにして遊泳モードとなることを発見した。この成果は、物理学で最高峰のPhysical Review Letters誌に掲載された。　６．壁近傍における大腸菌の遊泳挙動を調べたところ、高いせん断応力下では鞭毛の束化が阻害され、壁面から遠ざかる方向へと受動的に移動した。一方で、弱いせん断応力下では遊泳能を維持し、壁面近傍に長時間滞在した。この成果はCommunications Physics誌に掲載された。　これらの業績を含め、本年度は11編の査読付き雑誌論文と22件の国際会議論文を発表し、2件の招待講演を行った。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

これまでに、以下の特筆すべき研究業績が上がっている。　１．飢餓状態にある線虫が電場を利用して空中に飛び出し、昆虫などの足に付着して遠くへ移動する行動を発見した。この研究成果は生物学で定評のあるCurrent Biology誌に掲載され、読売新聞に図入りで掲載された（2023年7月31日）　２．流体力学分野で最高峰のAnnual Review of Fluid Mechanics誌から招待され、遊泳微生物の運動と行動について解説したレビュー論文を発表した。この業績は、本研究課題を代表する名誉なものである。　３．バイオメカニクス分野で最高峰のJournal of Biomechanics誌から招待され、微生物の挙動と数理モデルの50年をレビューした論文を前編と後編に分けて出版した。我々の研究が世界を代表するものであることを示している。　４．襟べん毛虫の群体が光刺激によって形状を変化するメカニズムを調べた研究では、微生物が光が強く餌が多い場所に長時間滞在し、光が弱く餌が少ない場所からは早く立ち去ることを示唆していた。生物物理学的に興味深い現象であり、この研究は世界最高峰のPhysical ReviewLetters誌に掲載された。　当初予想していなかった程のハイインパクトな研究成果が次々と出ているため、「当初の計画以上に進展している」と判断した。

Strategy for Future Research Activity

次年度は、主に以下の研究課題に取り組む。　１．通常の細菌の10倍の速度で遊泳するMO-1の遊泳挙動と、壁面近傍の行動を解明する。　２．微生物懸濁液を管路に流した際の微生物の挙動と凝集、走地性などを解明する。　３．精子の集団遊泳の数値シミュレーションを行い、協調遊泳による遊泳速度の増加や、集団としての配向構造などを解明する。　４．カイメンの襟細胞に着目し、鞭毛運動によるポンプ機能と摂食機能を解明する。　５．Volvox目の遊泳挙動を系統的に計測し、光に対する応答挙動の違いを明らかにする。

Research Products

• [Int'l Joint Research] University of Cambridge(英国)
• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Int'l Joint Research] China Medical University(中国)
• [Int'l Joint Research] University of Cambridge(英国)
• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Int'l Joint Research] University of Cambridge(英国)
• [Int'l Joint Research] University of Melbourne(オーストラリア)
• [Journal Article] Fluid Dynamics of Squirmers and Ciliated Microorganisms (2024)
  • Author(s): Ishikawa Takuji
  • Journal Title: Annual Review of Fluid Mechanics Volume: 56 Issue: 1 Pages: 119-145
  • DOI: 10.1146/annurev-fluid-121021-042929
  • Peer Reviewed / Open Access
• [Journal Article] Glucose stockpile in the intestinal apical brush border in C. elegans (2024)
  • Author(s): Saito Takumi、Kikuchi Kenji、Ishikawa Takuji
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 706 Pages: 149762-149762
  • DOI: 10.1016/j.bbrc.2024.149762
  • Peer Reviewed / Open Access
• [Journal Article] 50-year History and perspective on biomechanics of swimming microorganisms: Part I. Individual behaviours (2023)
  • Author(s): Ishikawa Takuji、Pedley T.J.
  • Journal Title: Journal of Biomechanics Volume: 158 Pages: 111706-111706
  • DOI: 10.1016/j.jbiomech.2023.111706
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 50-year history and perspective on biomechanics of swimming microorganisms: Part II. Collective behaviours (2023)
  • Author(s): Ishikawa Takuji、Pedley T.J.
  • Journal Title: Journal of Biomechanics Volume: 160 Pages: 111802-111802
  • DOI: 10.1016/j.jbiomech.2023.111802
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Flow-induced diffusion in a packed lattice of squirmers (2023)
  • Author(s): Kogure Yu、Omori Toshihiro、Ishikawa Takuji
  • Journal Title: Journal of Fluid Mechanics Volume: 971
  • DOI: 10.1017/jfm.2023.651
  • Peer Reviewed
• [Journal Article] Swimming, Feeding, and Inversion of Multicellular Choanoflagellate Sheets (2023)
  • Author(s): Fung Lloyd、Konkol Adam、Ishikawa Takuji、Larson Ben T.、Brunet Thibaut、Goldstein Raymond E.
  • Journal Title: Physical Review Letters Volume: 131 Issue: 16 Pages: 168401-168401
  • DOI: 10.1103/physrevlett.131.168401
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High shear flow prevents bundling of bacterial flagella and induces lateral migration away from a wall (2023)
  • Author(s): Yang Jinyou、Kikuchi Kenji、Ishikawa Takuji
  • Journal Title: Communications Physics Volume: 6 Issue: 1 Pages: 354-354
  • DOI: 10.1038/s42005-023-01471-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biophysical Analysis of Mechanical Signals in Immotile Cilia of Mouse Embryonic Nodes Using Advanced Microscopic Techniques (2023)
  • Author(s): Katoh Takanobu、Omori Toshihiro、Ishikawa Takuji、Okada Yasushi、Hamada Hiroshi
  • Journal Title: BIO-PROTOCOL Volume: 13 Issue: 14
  • DOI: 10.21769/bioprotoc.4715
  • Peer Reviewed / Open Access
• [Journal Article] Computational Fluid Dynamics of Swimming Microorganisms (2023)
  • Author(s): Omori Toshihiro、Ishikawa Takuji
  • Journal Title: Journal of the Physical Society of Japan Volume: 92 Issue: 12 Pages: 121002-121002
  • DOI: 10.7566/jpsj.92.121002
  • Peer Reviewed / Open Access
• [Journal Article] Caenorhabditis elegans transfers across a gap under an electric field as dispersal behavior (2023)
  • Author(s): Chiba Takuya、Okumura Etsuko、Nishigami Yukinori、Nakagaki Toshiyuki、Sugi Takuma、Sato Katsuhiko
  • Journal Title: Current Biology Volume: 33 Issue: 13 Pages: 2668-2677
  • DOI: 10.1016/j.cub.2023.05.042
  • Peer Reviewed / Open Access
• [Journal Article] Cellular Ethological Dynamics in Diorama Environments (2023)
  • Author(s): Nishigami Yukinori、Kunita Itsuki、Sato Katsuhiko、Nakagaki Toshiyuki
  • Journal Title: Journal of the Physical Society of Japan Volume: 92 Issue: 12 Pages: 121009-121009
  • DOI: 10.7566/jpsj.92.121009
  • Peer Reviewed / Open Access
• [Journal Article] Immotile cilia mechanically sense the direction of fluid flow for left-right determination (2023)
  • Author(s): Katoh Takanobu A.、Omori Toshihiro、Mizuno Katsutoshi、Sai Xiaorei、Minegishi Katsura、Ikawa Yayoi、Nishimura Hiromi、Itabashi Takeshi、Kajikawa Eriko、Hiver Sylvain、Iwane Atsuko H.、Ishikawa Takuji、Okada Yasushi、Nishizaka Takayuki、Hamada Hiroshi
  • Journal Title: Science Volume: 379 Issue: 6627 Pages: 66-71
  • DOI: 10.1126/science.abq8148
  • Peer Reviewed / Open Access
• [Journal Article] Light-sheet microscopy reveals dorsoventral asymmetric membrane dynamics of<i>Amoeba proteus</i>during pressure-driven locomotion (2023)
  • Author(s): Taniguchi Atsushi、Nishigami Yukinori、Kajiura-Kobayashi Hiroko、Takao Daisuke、Tamaoki Daisuke、Nakagaki Toshiyuki、Nonaka Shigenori、Sonobe Seiji
  • Journal Title: Biology Open Volume: 12 Issue: 2
  • DOI: 10.1242/bio.059671
  • Peer Reviewed / Open Access
• [Journal Article] Soft Microswimmer Powered by Fluid Oscillation (2022)
  • Author(s): Ishikawa Takuji、Morita Takeru、Omori Toshihiro
  • Journal Title: Journal of Robotics and Mechatronics Volume: 34 Issue: 2 Pages: 298-300
  • DOI: 10.20965/jrm.2022.p0298
  • ISSN: 0915-3942, 1883-8049
  • Year and Date: 2022-04-20
  • Peer Reviewed
• [Journal Article] Instability of an active fluid jet (2022)
  • Author(s): Ishikawa Takuji、Dang Thanh-Nghi、Lauga Eric
  • Journal Title: Physical Review Fluids Volume: 7 Issue: 9 Pages: 013104-013104
  • DOI: 10.1103/physrevfluids.7.093102
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reciprocating intestinal flows enhance glucose uptake in C. elegans (2022)
  • Author(s): Yuki Suzuki, Kenji Kikuchi, Keiko Numayama-Tsuruta, Takuji Ishikawa
  • Journal Title: Scientific reports Volume: 12 Issue: 1 Pages: 15310-15310
  • DOI: 10.1038/s41598-022-18968-1
  • Peer Reviewed / Open Access
• [Journal Article] Self-sustaining oscillation of two axonemal microtubules based on a stochastic bonding model between microtubules and dynein (2022)
  • Author(s): Omori T.、Munakata S.、Ishikawa T.
  • Journal Title: Physical Review E Volume: 106 Issue: 1 Pages: 014402-014402
  • DOI: 10.1103/physreve.106.014402
  • Peer Reviewed
• [Journal Article] Bacterial behaviors in confined diorama environments (2022)
  • Author(s): Ishikawa Takuji
  • Journal Title: Biophysical Journal Volume: 121 Issue: 13 Pages: 2487-2489
  • DOI: 10.1016/j.bpj.2022.05.045
  • Peer Reviewed
• [Journal Article] Influence of Respiratory Gas Density on Tidal Volume during Mechanical Ventilation: A Laboratory Investigation and Observational Study in Children (2022)
  • Author(s): Takahashi Kazuhiro、Toyama Hiroaki、Funahashi Yutaro、Kawana Shin、Ejima Yutaka、Kikuchi Kenji、Ishikawa Takuji、Yamauchi Masanori
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 256 Issue: 4 Pages: 271-281
  • DOI: 10.1620/tjem.2022.J003
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Switching of behavioral modes and their modulation by a geometrical cue in the ciliate Stentor coeruleus (2022)
  • Author(s): Echigoya Syun、Sato Katsuhiko、Kishida Osamu、Nakagaki Toshiyuki、Nishigami Yukinori
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 10 Pages: 1021469-1021469
  • DOI: 10.3389/fcell.2022.1021469
  • Peer Reviewed / Open Access
• [Journal Article] Simple dynamics underlying the survival behaviors of ciliates (2022)
  • Author(s): Takuya Ohmura, Yukinori Nishigami, Masatoshi Ichikawa
  • Journal Title: Biophysics and Physicobiology Volume: 19 Issue: 0 Pages: n/a
  • DOI: 10.2142/biophysico.bppb-v19.0026
  • ISSN: 2189-4779
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rheotaxis and migration of an unsteady microswimmer (2022)
  • Author(s): T. Omori, K. Kikuchi, M. Schmitz, M. Pavlovic, C.-H. Chuang, T. Ishikawa
  • Journal Title: Journal of Fluid Mechanics Volume: 930
  • DOI: 10.1017/jfm.2021.921
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lubrication theory and boundary element hybrid method for calculating hydrodynamic forces between particles in near contact (2022)
  • Author(s): Ishikawa Takuji
  • Journal Title: Journal of Computational Physics Volume: 452 Pages: 110913-110913
  • DOI: 10.1016/j.jcp.2021.110913
  • Peer Reviewed
• [Journal Article] Pairwise scattering and bound states of spherical microorganisms (2022)
  • Author(s): Darveniza C.、Ishikawa T.、Pedley T. J.、Brumley D. R.
  • Journal Title: Physical Review Fluids Volume: 7 Issue: 1 Pages: 013104-013104
  • DOI: 10.1103/physrevfluids.7.013104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of rheological properties on bacterial streamer formation (2021)
  • Author(s): Hiroki Kitamura, Toshihiro Omori, Takuji Ishikawa
  • Journal Title: Journal of the Royal Society Interface Volume: 18 Issue: 183 Pages: 20210546-20210546
  • DOI: 10.1098/rsif.2021.0546
  • Peer Reviewed / Open Access
• [Journal Article] Microbial Brazil nut effect (2021)
  • Author(s): Srivastava Atul、Kikuchi Kenji、Ishikawa Takuji
  • Journal Title: Soft Matter Volume: 17 Issue: 46 Pages: 10428-10436
  • DOI: 10.1039/d1sm01327k
  • Peer Reviewed / Open Access
• [Presentation] SOFT CAPSULE ROBOT CONTROLLED BY FLUID OSCILLATIONS (2023)
  • Author(s): Takuji Ishikawa
  • Organizer: DynaCaps2023
  • Int'l Joint Research / Invited
• [Presentation] HYDRODYNAMICS AND BEHAVIORAL DYNAMICS OF SWIMMING MICROORGANISMS (2023)
  • Author(s): Takuji Ishikawa
  • Organizer: JSB2023
  • Int'l Joint Research / Invited
• [Presentation] COLLECTIVE SWIMMING OF SPERM EMERGING FROM UNSTEADY HYDRODYNAMIC INTERACTIONS (2023)
  • Author(s): Toshihiro Omori,Nanami Taketoshi,Takuji Ishikawa
  • Organizer: JSB2023
  • Int'l Joint Research
• [Presentation] Improving Puncture Accuracy Using Vibrating Devices for Flexible Organs (2023)
  • Author(s): Y. Iwata , K. Kikuchi,K. Takase, T. Ishikawa
  • Organizer: ICFD2023
  • Int'l Joint Research
• [Presentation] Simulation Of Sea Urchin Sperm Rheotaxis (2023)
  • Author(s): R. Takagi , T. Omori, T. Ishikawa
  • Organizer: ICFD2023
  • Int'l Joint Research
• [Presentation] Numerical Simulation of Swimming Microorganisms in a Maxwellian Fluid (2023)
  • Author(s): K. Koitabashi , T. Omori, T. Ishikawa
  • Organizer: ICFD2023
  • Int'l Joint Research
• [Presentation] Turbulence Generator for Studying the Vertical Migration of Red Tide Microalgae (2023)
  • Author(s): W. Niu , K. Kikuchi, T. Ishikawa
  • Organizer: ICFD2023
  • Int'l Joint Research
• [Presentation] Collective Swimming of Spermatozoa Emerging from Unsteady Hydrodynamic Interactions (2023)
  • Author(s): Toshihiro Omori, Nanami Taketoshi and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Viscoelastic Analysis of Fermenting Puffing Dough (2023)
  • Author(s): Kenji Kikuchi, Kyosuke Kimura, Keiko Numayama-Tsuruta and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Transdermal Transport through Intercellular Gaps of Liposomes in Suspensions (2023)
  • Author(s): Jiawei Huang, Kenji Kikuchi, Keiko Numayama-Tsuruta and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Enhancement of Mass Transport by an Aggregation of Swimming Microorganisms (2023)
  • Author(s): Yu Kogure, Toshihiro Omori and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] A Deformable Capsule Propelled by inside Microswimmers (2023)
  • Author(s): Zhihan Huang, Toshihiro Omori and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Internal Flow of C. Elegans Body Promoted by Locomotion (2023)
  • Author(s): Yasuhiro Asoshina, Kenji Kikuchi and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Swimming Simulation of Ascidian Sperm Chemotaxis (2023)
  • Author(s): Sara Kamijo, Toshihiro Omori, Kogiku Shiba and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Flying Yeast: Aerosol Particles Released during the Fermen (2023)
  • Author(s): Ryoji Onishi, Kenji Kikuchi and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Stagnation Phenomenon of Motile E. Coli in a Folding Wall (2023)
  • Author(s): Toma Isaka, Kenji Kikuchi, Keiko Numayama-Tsuruta and Takuji Ishikawa
  • Organizer: AP-Biomech 2023
  • Int'l Joint Research
• [Presentation] Microswimmers Navigating The Blood: Unraveling Locomotion Characteristics (2023)
  • Author(s): C. Wu, T. Omori, T. Ishikawa
  • Organizer: 76th Annual Meeting of the APS Division of Fluid Dynamics
  • Int'l Joint Research
• [Presentation] Intestinal folds accumulate bacteria through physical and biological factors (2023)
  • Author(s): J. Yang, T. Isaka,K. Kikuchi, K. Numayama-Tsuruta,T. Ishikawa
  • Organizer: 76th Annual Meeting of the APS Division of Fluid Dynamics
  • Int'l Joint Research
• [Presentation] Efficient Blood Propulsion of Squirmer-Type Microrobots (2023)
  • Author(s): C. Wu, T. Omori, T. Ishikawa
  • Organizer: 76th Annual Meeting of the APS Division of Fluid Dynamics
  • Int'l Joint Research
• [Presentation] Spherical choanocyte chamber of sponge achieves optimized pumping efficiency (2023)
  • Author(s): T. Ogawa, S. Koyama, T. Omori, K. Kikuchi, R. Goldstein, T. Ishikawa
  • Organizer: 76th Annual Meeting of the APS Division of Fluid Dynamics
  • Int'l Joint Research
• [Presentation] Flow-induced diffusivity in a packed suspension of swimming microorganisms (2023)
  • Author(s): Y. Kogure,T. Omori, T. Ishikawa
  • Organizer: 76th Annual Meeting of the APS Division of Fluid Dynamics
• [Presentation] Microstructure appearing in soft microswimmer suspensions (2023)
  • Author(s): K. Kubo, T. Omori, T. Ishikawa
  • Organizer: 76th Annual Meeting of the APS Division of Fluid Dynamics
• [Presentation] Bubble lnduced Transport Phenomena in Yeast Fermentation (2022)
  • Author(s): Takuji Ishikawa, Atul Srivastava, Kenji Kikuchi
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Dynamic simulation of a 3D sperm suspension (2022)
  • Author(s): Nanami Taketoshi,Toshihiro Omori,Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Computational Biomechanics of the Sponge's Choanocyte Chamber (2022)
  • Author(s): Takumi Ogawa,Toshihiro Omori,Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Microstructure of a Suspension of Soft Microswimmers (2022)
  • Author(s): Kiyoto Kubo,Toshihiro Omori,Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Mass transport in induced by a packed lattice of squirmers (2022)
  • Author(s): Yu Kogure,Toshihiro Omori,Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Bubble Structure in proofing Dough visualized by X-ray Microtomography (2022)
  • Author(s): Kyosuke Kimura, Kenji Kikuchi, Keiko Numayama, Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Microbial transport of E.coli in the gut of a zebrafish larva,9th World Congress of Biomechanics,O-21086,2022 (2022)
  • Author(s): Yuta Kikunaga,Kenji Kikuchi, Keiko Numayama-Tsuruta, Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Transport of liposome in zebrafish larvae intestine (2022)
  • Author(s): Jiawei Huang,Kenji Kikuchi, Keiko Numayama-Tsuruta, Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] Sustainable filter feeding and self-cleaning on a fresh-water sponge (2022)
  • Author(s): Kei Kawashima, Kenji Kikuchi, Takuji Ishikawa
  • Organizer: 9th World Congress of Biomechanics
  • Int'l Joint Research
• [Presentation] MODELING SPERM SUSPENSION IN THREE DIMENSIONS (2022)
  • Author(s): Nanami Taketoshi, Toshihiro Omori and Takuji Ishikawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] COMPUTATIONAL MODELING OF THE SPONGE'S CHOANOCYTE CHAMBER (2022)
  • Author(s): Takumi Ogawa,Toshihiro Omori,Kenji Kikuchi and Takuji Ishikawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] VISUALIZATION OF A FRESHWATER-SPONGE SNEEZING (2022)
  • Author(s): Kei Kawashima, Kenji Kikuchi and Takuji Ishikawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] VISUALIZATION OF FLOW FIELD INDUCED BY HYDRODYNAMIC INTERACTIONS OF SWIMMING MICROORGANISM (2022)
  • Author(s): Kiyoto Kubo, Toshihiro Omori and Takuji Ishikawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] SIMULATION OF A PACKED SUSPENSION OF MICROSWIMMERS (2022)
  • Author(s): Yu Kogure,Toshihiro Omori and Takuji Ishikawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] Visualization of Bubble Dynamics inside the Proofing Bread Dough using X-ray Microtomography (2022)
  • Author(s): Kyosuke Kimura, Kenji Kikuchi, Keiko Numayama, Takuji Ishikawa and Taimei Miyagawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] Visualization of microbial transport in the gut of a zebrafish larva (2022)
  • Author(s): Yuta Kikunaga, Kenji Kikuchi, Keiko Numayama-Tsuruta and Takuji Ishikawa
  • Organizer: PSFVIP13
  • Int'l Joint Research
• [Presentation] Modeling of Internal Driving Force During Sperm Hyperactivation (2022)
  • Author(s): S.Kamijo, T.Omori, T.Ishikawa
  • Organizer: ICFD2022
  • Int'l Joint Research
• [Presentation] Flying Yeast:Aerosol Particles Released during the Fermentation (2022)
  • Author(s): R.Onishi, K.kikuchi, T.Ishikawa
  • Organizer: ICFD2022
  • Int'l Joint Research
• [Presentation] Flow Promoted by Locomotions in C. elegans (2022)
  • Author(s): Y.Asoshina, K.kikuchi, T.Ishikawa
  • Organizer: ICFD2022
  • Int'l Joint Research
• [Presentation] Pumping Efficiency of Spongillidae's Choanocyte Chamber (2022)
  • Author(s): Takumi Ogawa,Toshihiro Omori,Kenji Kikuchi and Takuji Ishikawa
  • Organizer: ISABMEC2022
  • Int'l Joint Research
• [Presentation] Behavior of the ciliate Tetrahymena in response to the extracellular environment (2022)
  • Author(s): Yukinori Nishigami
  • Organizer: The 23rd RIES-HOKUDAI International Symposium
  • Int'l Joint Research
• [Presentation] 微生物の走性・行動の力学モデル (2022)
  • Author(s): 石川拓司
  • Organizer: 「ジオラマ環境で覚醒する原生知能を定式化する細胞行動力学」シンポジウム
  • Invited
• [Presentation] Dynamics of a swimming microorganism suspension (2021)
  • Author(s): Kiyoto Kubo, Toshihiro Omori, Takuji Ishikawa
  • Organizer: The 11th Asian-Pacific Conference on Biomechanics
  • Int'l Joint Research
• [Presentation] Numerical simulation of the sponge's choanocyte chamber (2021)
  • Author(s): Takumi Ogawa, Toshihiro Omori, Takuji Ishikawa
  • Organizer: The 11th Asian-Pacific Conference on Biomechanics
  • Int'l Joint Research
• [Presentation] Instantaneous puncture for accurate needle insertion in percutaneous intervention (2021)
  • Author(s): Kojiro Sugiyama, Kenji Kikuchi, Tomomi Sato, Sota Oguro, Satoru Yanagaki, Kei Takase, Takuji Ishikawa
  • Organizer: The 11th Asian-Pacific Conference on Biomechanics
  • Int'l Joint Research
• [Presentation] Numerical analysis of collective swimming of sperm in three dimensions (2021)
  • Author(s): Nanami TAKETOSHI, Toshihiro OMORI, Takuji ISHIKAWA
  • Organizer: The 11th Asian-Pacific Conference on Biomechanics
  • Int'l Joint Research
• [Presentation] Mass transport in an aggregation of swimming microorganisms (2021)
  • Author(s): Yu Kogure, Toshihiro Omori, Takuji Ishikawa
  • Organizer: The 11th Asian-Pacific Conference on Biomechanics
  • Int'l Joint Research
• [Remarks] Biological Flow Studies Laboratory
  • URL: http://www.bfsl.mech.tohoku.ac.jp/index_jp.html