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Regulation of Reactivity of Highly Reactive Species by Utilizing Large Molecular Cavities

Planned Research

Project AreaMolecule Activation Directed toward Straightforward Synthesis
Project/Area Number 22105011
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Institute of Technology

Principal Investigator

GOTO Kei  東京工業大学, 理工学研究科, 教授 (70262144)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords有機化学 / 物質変換 / 分子活性化 / 活性種 / 分子空孔 / 有機元素科学 / 酵素モデル / ヨウ化セレネニル / ホスフィン配位子 / 触媒反応 / 速度論的安定化
Outline of Final Research Achievements

In the active site of enzymes, reactive species that are very unstable in artificial systems are sometimes stabilized and play an important role in bioactivation of substrate molecules with extraordinarily high reactivity. For modeling such fabulous features of enzymatic reactions, various types of nano-sized molecular cavities were synthesized and applied to molecular activation. Development of novel synthetic reactions by taking advantage of unique features of reactive intermediates of enzymatic reactions as well as modeling of bioactivation of small molecules such as reactive nitrogen species were investigated.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (96 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (76 results) (of which Invited: 9 results) Book (2 results)

  • [Journal Article] Synthesis of a Stable Selenoaldehyde (RCH=Se) by Self-Catalyzed Thermal Dehydration of a Primary-Alkyl-Substituted Selenenic Acid (RCH2SeOH)2015

    • Author(s)
      Shohei Sase, Ryo Kakimoto, Kei Goto
    • Journal Title

      Angewandte Chemie, International Edition

      Volume: 54 Issue: 3 Pages: 901-904

    • DOI

      10.1002/anie.201409485

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oxygen-atom-transfer Reactions of a Palladium(II) Peroxocarbonate Complex2015

    • Author(s)
      Shohei Sase, Maki Hashimoto, Kei Goto
    • Journal Title

      Chemistry Letters

      Volume: 44 Issue: 2 Pages: 157-159

    • DOI

      10.1246/cl.140935

    • NAID

      130004703972

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis, Structure, and Reactivities of a Stable Primary-alkyl-substituted Sulfenic Acid2015

    • Author(s)
      Mihihiro Ishihara, Noriaki Abe, Shohei Sase, Kei Goto
    • Journal Title

      Chemistry Letters

      Volume: 44 Issue: 5 Pages: 615-617

    • DOI

      10.1246/cl.150046

    • NAID

      130005067978

    • Description
      【掲載確定】印刷中
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient End-Capping Synthesis of Neutral Donor-Acceptor [2]Rotaxanes under Additive-Free and Mild Conditions2014

    • Author(s)
      Yuya Domoto, Shohei Sase, Kei Goto
    • Journal Title

      Chemistry - A European Journal

      Volume: 20 Issue: 48 Pages: 15998-16005

    • DOI

      10.1002/chem.201404187

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chloro-(η6-p-cymene)-{3-[3,5-bis(2,6-dimethylphenyl)-1,2-phenylene]-1-(2,6,2"6"-tetramethyl-1,1':3',1"-terphenyl-5'-yl)imidazol-2-ylidene}-ruthenium(II) benzene disolvate2014

    • Author(s)
      Shohei Sase, Yuriko Ikehara, Kei Goto
    • Journal Title

      Acta Crystallographica, Section E

      Volume: 70 Issue: 12 Pages: m394-m394

    • DOI

      10.1107/s160053681402399x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transnitrosation from a stable thionitrate to an amine with concomitant formation of a sulfenic acid2013

    • Author(s)
      Kei Goto, Shuhei Yoshikawa, Taku Ideue, Shohei Sase
    • Journal Title

      Journal of Sulfur Chemistry

      Volume: 34 Issue: 6 Pages: 705-710

    • DOI

      10.1080/17415993.2013.794801

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iodide-Promoted Deselenylation of β-Chloro- and β-Oxyselenides to Form Alkenes and Selenenyl Iodides2012

    • Author(s)
      Shohei Sase
    • Journal Title

      Chemistry Letters

      Volume: 41 Issue: 8 Pages: 766-768

    • DOI

      10.1246/cl.2012.766

    • NAID

      10030946954

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copper(I)-Dioxygen Reactivity in a Sterically Demanding Tripodal Tetradentate tren Ligand. Formation and Reactivity of a Mononuclear Copper(II) End-on Superoxo Complex2012

    • Author(s)
      Shinobu Itoh, et al.
    • Journal Title

      Eur. J. Inorg. Chem.

      Volume: 2012 Issue: 29 Pages: 4574-4578

    • DOI

      10.1002/ejic.201200177

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iodide-Promoted Deselenylation of β-Chloro- and β-Oxyselenides to Form Alkenes and Selenenyl Iodides2012

    • Author(s)
      S.Sase, K.Ebisawa, K.Goto
    • Journal Title

      Chem.Lett.

      Volume: (In press)

    • NAID

      10030946954

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses of Biologically-relevant Reactive Sulfur Species by Utilizing a Primary Alkyl Steric Protection Group2011

    • Author(s)
      S.Sase, Y.Aoki, N.Abe, K.Goto
    • Journal Title

      Phosphorus, Sulfur Silicon Relat.Elem.

      Volume: 186 Issue: 5 Pages: 1255-1258

    • DOI

      10.1080/10426507.2010.538778

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of a Unique Fluorosilene-KF Complex Bearing Bulky Substituents2011

    • Author(s)
      E.Mieda, T.Sasamori, S.Sase, K.Goto, N.Tokitoh
    • Journal Title

      Chem.Lett.

      Volume: 40 Issue: 2 Pages: 196-197

    • DOI

      10.1246/cl.2011.196

    • NAID

      130004426144

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子のボウルを使って生体反応活性種をモデル化する2011

    • Author(s)
      後藤敬
    • Journal Title

      化学と教育

      Volume: 59 Pages: 604-605

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子キャビティを活用した含ヨウ素高反応性中間体の安定化2011

    • Author(s)
      後藤敬
    • Journal Title

      SIS Letters

      Volume: 12 Pages: 604-605

    • NAID

      40022792022

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catalyst-free Syntheses of [2]Rotaxanes Utilizing a Pentacoordinated Hydrosilane as an End-capping Agent2010

    • Author(s)
      Y.Domoto, A.Fukushima, Y.Kasuga, S.Sase, K.Goto, T.Kawashima
    • Journal Title

      Org.Lett.

      Volume: 12 Pages: 2586-2589

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling of the 5'-Deiodination of Thyroxine by Iodothyronine Deiodinase : Chemical Corroboration of a Selenenyl Iodide Intermediate2010

    • Author(s)
      K.Goto, D.Sonoda, K.Shimada, S.Sase, T.Kawashima
    • Journal Title

      Angew.Chem., Int.Ed.

      Volume: 49 Pages: 545-547

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photo- and Thermal Isomerization of Shuttlecock- and Bowl-Equipped Phenylazopyridines2010

    • Author(s)
      K.Suwa, J.Otsuki, K.Goto
    • Journal Title

      J.Phys.Chem.A

      Volume: 114 Pages: 884-890

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 5,6,7,12-Tetrahydro-6-(1-methylethyl)-12-phenyldibenz[c,f][1,5]azasilocine2010

    • Author(s)
      K.Goto, A.Fukushima, T.Kawashima
    • Journal Title

      Acta Crystallogr., Sect.E

      Volume: 66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of Pentacoordinated Phenoxysilane and Carboxysilanes with Intramolecular Nitrogen-Silicon Coordination2010

    • Author(s)
      Y.Domoto, K.Saruhashi, A.Fukushima, S.Sase, K.Goto, T.Kawashima
    • Journal Title

      Phosphorus, Sulfur Silicon Relat.Elem.

      Volume: 185 Pages: 1221-1229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ペンチプチセン骨格に基づく分子キャビティを活用したS-ニトロソチオールおよび関連化学種の反応性に関する研究2015

    • Author(s)
      森田貴博,佐瀬祥平,高橋広奈,河合明雄,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and Reactivities of a Cysteine Sulfenic Acid by Taking Advantage of a Large Molecular Cavity2015

    • Author(s)
      佐野 司,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and Reactions of a Primary-alkyl-substituted Sulfenate Anion Bearing a Cavity-shaped Molecular Framework2015

    • Author(s)
      石原充裕,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 巨大分子キャビティを活用したセレノシステイン由来ヨウ化セレネニルの合成2015

    • Author(s)
      唐崎貴史,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヨウ化セレネニルによる求電子的活性化を活用した新規な環化反応の開発2015

    • Author(s)
      星野由紀子,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 巨大分子キャビティ型分子骨格を有する含セレン一級アルキル置換高反応性化学種の合成2015

    • Author(s)
      木村龍太郎,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピンサー型三座配位子を有する遷移金属錯体とN2Oとの反応2015

    • Author(s)
      池原由里子,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナノサイズ分子空孔を活用した活性化学種の反応制御2015

    • Author(s)
      後藤 敬
    • Organizer
      新学術領域研究「分子活性化」第8回公開シンポジウム
    • Place of Presentation
      豊中
    • Year and Date
      2015-01-23 – 2015-01-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Bowl型立体保護基を活用した一級アルキル置換およびアリール置換スルフェン酸の反応性の解明2014

    • Author(s)
      石原充裕,井手上拓,佐瀬祥平,金友拓哉,石田尚行,後藤 敬
    • Organizer
      第41回有機典型元素化学討論会
    • Place of Presentation
      宇部
    • Year and Date
      2014-11-27 – 2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] かさ高いホリアルキル置換ヘンチフチセン骨格を活用した含硫黄高反応性化学種の合成2014

    • Author(s)
      森田貴博,中村正輝,荒井浩二,佐瀬祥平,後藤 敬
    • Organizer
      第41回有機典型元素化学討論会
    • Place of Presentation
      宇部
    • Year and Date
      2014-11-27 – 2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性化学種の反応制御を指向したナノサイズ分子キャビティの設計と応用2014

    • Author(s)
      後藤 敬
    • Organizer
      第15回リング・チューブ超分子研究会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ボウル型立体保護基を活用した初めての一級アルキル置換スルフェン酸の合成2014

    • Author(s)
      石原充裕,阿部憲明,佐瀬祥平,後藤 敬
    • Organizer
      第25回基礎有機化学討論会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-07 – 2014-09-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Modeling of Reactive Intermediates Derived from Cysteine Thiols by Utilizing Molecular Cavities2014

    • Author(s)
      Kei Goto
    • Organizer
      26th International Symposium on the Organic Chemistry of Sulfur
    • Place of Presentation
      Istanbul (Turkey)
    • Year and Date
      2014-08-24 – 2014-08-29
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Invited
  • [Presentation] Nano-Sized Molecular Cavity for Modeling Reactive Species Derived from Cysteine Thiols2014

    • Author(s)
      Kei Goto
    • Organizer
      The 41st International Conference on Coordination Chemistry
    • Place of Presentation
      Singapore
    • Year and Date
      2014-07-21 – 2014-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Modeling of Cysteine Thionitrate Intermediates by Taking Advantage of a Nano-sized Molecular Cavity2014

    • Author(s)
      Kei Goto, Tsukasa Sano, Shohei Sase
    • Organizer
      The International Symposium on Reactive Intermediates and Unusual Molecules
    • Place of Presentation
      広島
    • Year and Date
      2014-04-01 – 2014-04-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Organoelement Chemistry in Mechanistic Studies on Biological Reactions2014

    • Author(s)
      Kei Goto
    • Organizer
      US/Japan Joint Symposium on Advanced Organo-Main Group Chemistry
    • Place of Presentation
      Nagoya (Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] キャビティ型分子骨格を活用した生体反応活性種のモデル研究2014

    • Author(s)
      後藤 敬
    • Organizer
      第2回生物元素戦略研究会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヨウ化セレネニルを用いたアルケンのアミノセレン化反応の開発2014

    • Author(s)
      高橋絵里歌,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 活性窒素種によるS-ニトロソチオールの酸化反応に関する機構的研究2014

    • Author(s)
      井手上拓,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 巨大分子キャビティに内包されたシステインチオールと硝酸エステルの反応2014

    • Author(s)
      佐野 司,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bowl型立体保護基を有するN-ヒドロキシセレネンアミドとチオールとの反応2014

    • Author(s)
      石原充裕,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bowl型骨格を有する一級アルキル置換セレネン酸から安定なセレノアルデヒドへの変換2014

    • Author(s)
      柿本 涼,佐瀬祥平,後藤 敬
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] さまざまな立体環境下におけるN-ヒドロキシスルフェンアミドの合成と性質2013

    • Author(s)
      後藤 敬
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学(草津)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bowl型N-複素環カルベン配位子を有するPd(II)錯体の反応性2013

    • Author(s)
      後藤 敬
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学(草津)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] S-ニトロソシステイン誘導体の熱分解反応機構の解明2013

    • Author(s)
      後藤 敬
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学(草津)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一級アルキル置換セレネン酸の脱水反応による安定なセレノアルデヒドの合成2013

    • Author(s)
      後藤 敬
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学(草津)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] ロタキサン骨格を活用した新規なキャビ ティ型分子の構築2013

    • Author(s)
      後藤 敬
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学(草津)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modeling of Highly Reactive Intermediates in the Reaction of Cysteine Thiols and Reactive Nitrogen Species2013

    • Author(s)
      Kei Goto
    • Organizer
      6th Heron Island Conference on Reactive Intermediates and Unusual Molecules
    • Place of Presentation
      Queensland (Australia)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Synthesis and Application of Cysteine Model Compounds Based on Nano-sized Molecular Cavities2013

    • Author(s)
      Kei Goto
    • Organizer
      The 16th Japan-Korea Seminar on Organic Chemistry
    • Place of Presentation
      Sendai (Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ナノサイズキャビティ型骨格を有するセレノシステインモデル化合物の合成と応用2013

    • Author(s)
      後藤 敬,柿本 涼,佐瀬祥平
    • Organizer
      第10回ホスト・ゲスト化学シンポジウム
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 巨大分子空孔を活用した生体内における活性窒素種の反応過程に関するモデル研究2013

    • Author(s)
      後藤 敬
    • Organizer
      新学術領域研究「分子活性化」第5回公開シンポジウム
    • Place of Presentation
      姫路
    • Related Report
      2013 Annual Research Report
  • [Presentation] S-ニトロソシステイン誘導体の熱分解機構に関する速度論的研究2013

    • Author(s)
      井手上拓,佐瀬祥平,後藤 敬,Manik Ghosh,永瀬 茂
    • Organizer
      第24回基礎有機化学討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 一級アルキル置換セレネン酸の合成と安定なセレノアルデヒドへの変換2013

    • Author(s)
      柿本 涼,佐瀬祥平,後藤 敬
    • Organizer
      第24回基礎有機化学討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bowl型分子キャビティを活用したセレン含有メチオニンスルホキシド還元酵素の反応機構に関するモデル研究2013

    • Author(s)
      柿本 涼,佐瀬祥平,後藤 敬
    • Organizer
      第40回有機典型元素化学討論会
    • Place of Presentation
      東大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bowl型立体保護基を活用したNO+によるS-ニトロソチオールの活性化機構の解明2013

    • Author(s)
      井手上拓,佐瀬祥平,後藤 敬
    • Organizer
      第40回有機典型元素化学討論会
    • Place of Presentation
      東大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] S-ニトロシステインからチオールへのニトロソ転移の反応機構の解明2013

    • Author(s)
      佐野 司,佐瀬祥平,後藤 敬
    • Organizer
      第40回有機典型元素化学討論会
    • Place of Presentation
      東大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bowl型立体保護基を活用した初めてのN-ヒドロキシセレネンアミドの合成2013

    • Author(s)
      石原充裕,佐瀬祥平,後藤 敬
    • Organizer
      第40回有機典型元素化学討論会
    • Place of Presentation
      東大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] キャビティ型置換基を活用したヨウ化セレネニルのアルケン活性化機構に関する研究2013

    • Author(s)
      高橋絵里歌,海老澤和明,佐瀬祥平,後藤 敬
    • Organizer
      第40回有機典型元素化学討論会
    • Place of Presentation
      東大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 巨大分子キャビティに内包された高反応性システイン誘導体の合成2012

    • Author(s)
      後藤 敬
    • Organizer
      第39回有機典型元素化学討論会
    • Place of Presentation
      いわて県民情報交流センター(盛岡)
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] 様々な置換基をもつチオールとHNO供与体との反応2012

    • Author(s)
      後藤 敬
    • Organizer
      第39回有機典型元素化学討論会
    • Place of Presentation
      いわて県民情報交流センター(盛岡)
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bowl型骨格をもつセレン化合物を活用したメチオニンスルホキシド還元酵素のモデル研究2012

    • Author(s)
      後藤 敬
    • Organizer
      第39回有機典型元素化学討論会
    • Place of Presentation
      いわて県民情報交流センター(盛岡)
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] S-ニトロソチオールの二分子間分解過程に関する機構的研究2012

    • Author(s)
      後藤 敬
    • Organizer
      第39回有機典型元素化学討論会
    • Place of Presentation
      いわて県民情報交流センター(盛岡)
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Application of Cavity-shaped Molecules to Modeling of Biologically-relevant Reactive Sulfur Species2012

    • Author(s)
      Kei Goto
    • Organizer
      The 15th International Symposium “Advances in the Chemistry of Heteroorganic Compounds”
    • Place of Presentation
      Lodz(Poland)
    • Year and Date
      2012-11-16
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Modeling of Chalcogen-containing Reactive Intermediates of Biological Reactions by Utilizing Molecular Cavities2012

    • Author(s)
      Kei Goto
    • Organizer
      XII International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds
    • Place of Presentation
      Czestchowa(Poland)
    • Year and Date
      2012-11-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Modeling of the Chemical Processes Involving Reactive Nitrogen Species and Cysteine Thiols2012

    • Author(s)
      Kei Goto
    • Organizer
      2nd International Symposium on Molecular Activation
    • Place of Presentation
      東大寺文化センター(奈良)
    • Year and Date
      2012-11-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] デンドリマー型ナノサイズ分子キャビティを活用したシステインチオニトラートのモデル研究2012

    • Author(s)
      後藤 敬
    • Organizer
      第23回基礎有機化学討論会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bowl型NHC配位子を有する2価パラジウム錯体の合成と構造2012

    • Author(s)
      後藤 敬
    • Organizer
      第23回基礎有機化学討論会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヨウ素-セレン結合の特性を活用した合成反応の開発2012

    • Author(s)
      後藤 敬
    • Organizer
      第15回ヨウ素学会シンポジウム
    • Place of Presentation
      千葉大学(千葉)
    • Year and Date
      2012-09-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 内部にシステインユニットを有するナノサイズ分子キャビティの開発と応用2012

    • Author(s)
      後藤 敬
    • Organizer
      第9回ホスト・ゲスト化学シンポジウム
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-05-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Elucidation of the Reactivity of Biologically-relevant Reactive Sulfur Species by Utilizing Molecular Cavities2012

    • Author(s)
      Kei Goto
    • Organizer
      The 10th International Conference on Heteroatom Chemistry
    • Place of Presentation
      京都大学(宇治)
    • Year and Date
      2012-05-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Modeling of the Key Reduction Step of Selenocysteine-containing Methionine Sulfoxide Reductase2012

    • Author(s)
      Kei Goto
    • Organizer
      The 10th International Conference on Heteroatom Chemistry
    • Place of Presentation
      京都大学(宇治)
    • Year and Date
      2012-05-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Investigation on Disulfide Formation from S-Nitrosothiols by Taking Advantage of a Bowl-shaped Substituent2012

    • Author(s)
      Kei Goto
    • Organizer
      The 10th International Conference on Heteroatom Chemistry
    • Place of Presentation
      京都大学(宇治)
    • Year and Date
      2012-05-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis and Reactivity of a Cysteine Thionitrate Derivative by Taking Advantage of a Bowl-shaped Molecular Cavity2012

    • Author(s)
      Kei Goto
    • Organizer
      The 10th International Conference on Heteroatom Chemistry
    • Place of Presentation
      京都大学(宇治)
    • Year and Date
      2012-05-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reactivity of N-Hydroxysulfenamides as Oxidizing Agents2012

    • Author(s)
      Kei Goto
    • Organizer
      The 10th International Conference on Heteroatom Chemistry
    • Place of Presentation
      京都大学(宇治)
    • Year and Date
      2012-05-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規なキャビティ型ホスフィン配位子の構造的特性の解析と触媒反応への応用2012

    • Author(s)
      梅本明成, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] デンドリマー型分子キャビティを活用したS-ニトロソおよびS-ニトロシステイン誘導体の合成と反応2012

    • Author(s)
      佐野司, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] HNO供与体としてのN-ヒドロキシスルフェンアミドの反応性2012

    • Author(s)
      石原充裕, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bowl型分子キャビティを活用したセレノールによるスルホキシド還元過程の解明2012

    • Author(s)
      柿本涼, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヨウ化セレネニルの生成を鍵とした新規合成反応の開発2012

    • Author(s)
      海老澤和明, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bowl型分子キャビティを活用したS-ニトロソチオールの二分子間分解反応の解明2012

    • Author(s)
      井手上拓, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] フェニレンデンドリマー骨格に基づくキャビティ型反応剤および配位子の開発と応用2012

    • Author(s)
      後藤敬
    • Organizer
      新学術領域研究「分子活性化」第2回公開シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Modeling of Reactive Species Derived from Cysteine and Selenocysteine Residues by Utilizing a Phenylene-based Molecular Cavity2011

    • Author(s)
      K.Goto
    • Organizer
      1st International Sympojium on Creation of Functional Materials
    • Place of Presentation
      つくば(招待講演)
    • Year and Date
      2011-12-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bowl型分子キャヒティを活用したyヒトロキシスルフェンアミトの反応性に関するモテル研究2011

    • Author(s)
      石原充裕, 吉川修平, 佐瀬祥平, 後藤敬
    • Organizer
      第38回有機典型元素化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子キャビティを活用した含高周期典型元素活性種の反応性制御2011

    • Author(s)
      後藤敬
    • Organizer
      第38回有機典型元素化学討論会
    • Place of Presentation
      金沢(招待講演)
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規なBowl型アリールジメチルホスフィン配位子を有するPd錯体の合成と応用2011

    • Author(s)
      梅本明成, 佐瀬祥平, 後藤敬
    • Organizer
      第38回有機典型元素化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reaction of Alkenes Activated by Selenium Reagents Bearing a Cavity-shaped Framework2011

    • Author(s)
      S.Sase, K.Ebisawa K.Goto
    • Organizer
      1st International Symposium on Molecular Activation
    • Place of Presentation
      淡路
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Modeling of Biologically-relevant Reactive Sulfur Species by Utilizing Molecular Cavities2011

    • Author(s)
      K.Goto, N.Abe, M.Ishihara, S.Sase
    • Organizer
      The 15th Japan-Korea Seminar on Organic Chemistry
    • Place of Presentation
      Gyeongiu, Korea(招待講演)
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] デンドリマー型分子キャビティを活用した安定なシステインヨウ化スルフェニルの合成2011

    • Author(s)
      佐野司, 三崎朋子, 佐瀬祥平, 後藤敬
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] キャビティ型置換基を有するヨウ化セレネニルにより活性化されたアルケンの反応2011

    • Author(s)
      海老澤和明, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] メタフェニレンデンドリマー骨格を有する新規なボウル型アリールジメチルホスフィン配位子の合成とその応用2011

    • Author(s)
      梅本明成, 吉川修平, 佐瀬祥平, 後藤敬
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 巨大分子空孔を活用した活性化学種の合成と応用2011

    • Author(s)
      後藤敬
    • Organizer
      新学術領域研究「直截的物質変換をめざした分子活性化法の開発」第1回公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Modeling of Reactive Species Derived from Cysteine and Selenocysteine Residues2010

    • Author(s)
      K.Goto
    • Organizer
      TITech/UniGE Symposium 2010
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bowl型分子キャビティを活用したS-ニトロソチオールの熱分解機構の解明2010

    • Author(s)
      阿部憲明, 佐瀬祥平, 後藤敬
    • Organizer
      第37回有機典型元素化学討論会
    • Place of Presentation
      室蘭
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヨウ化セレネニルの特性を利用したアルケンの活性化2010

    • Author(s)
      海老澤和明, 佐瀬祥平, 園田大樹, 川島隆幸, 後藤敬
    • Organizer
      第37回有機典型元素化学討論会
    • Place of Presentation
      室蘭
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Syntheses of Biologically-relevant Reactive Sulfur Species by Utilizing a Primary Alkyl Steric Protection Group2010

    • Author(s)
      K.Goto, Y.Aoki, N.Abe, S.Sase
    • Organizer
      24th International Symposium on the Organic Chemistry of Sulfur
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 活性化学種の反応制御を指向したナノサイズ分子キャビティの開発2010

    • Author(s)
      後藤敬
    • Organizer
      有機合成化学協会関東支部有機合成化学ミニシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Book] Synergy in Supramolecular Chemistry2014

    • Author(s)
      Kei Goto
    • Total Pages
      339
    • Publisher
      CRC Press
    • Related Report
      2014 Annual Research Report
  • [Book] Synergy in Supramolecular Chemistry2014

    • Author(s)
      Kei Goto et al.
    • Publisher
      CRC Press/Auerbach/Chapman & Hall/Productivity Press
    • Related Report
      2013 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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