| Co-Investigator(Renkei-kenkyūsha) |
TABATA Hidenori 慶應義塾大学, 医学部, 専任講師 (80301761)
ARAMAKI Michihiko 慶應義塾大学, 医学部, 特任助教 (20338099)
NODA Mariko 慶應義塾大学, 医学部, 特任助教 (50571311)
OGAWA Yukino 慶應義塾大学, 医学部, 特任助教 (10624405)
TANAKA Daisuke 慶應義塾大学, 医学部, 特任助教 (90456921)
KANATANI Shigeaki 慶應義塾大学, 医学部, 特任助教 (50424180)
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| Budget Amount *help |
¥176,540,000 (Direct Cost: ¥135,800,000、Indirect Cost: ¥40,740,000)
Fiscal Year 2014: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2013: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Fiscal Year 2012: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000)
Fiscal Year 2011: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2010: ¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
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| Outline of Final Research Achievements |
We have uncovered some novel dynamics and regulatory mechanisms of migrating cells in the developing cerebral cortex. First, we revealed the migratory profiles of inhibitory interneurons and their evolutionary change in the migratory ability. We found that the cellular environment in the neocortical layers II~IV has some features unique to mammals. Secondly, we discovered novel modes of cell migration in the developing cortex. Thirdly, we analyzed the cellular interaction among the moving cortical cells using both mathematical modeling and a cell culture system.
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