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The role of forces and the cellular responses to them as a mechanism for epithelial morphogenesis

Planned Research

Project AreaCross-talk between moving cells and microenvironment as a basis of emerging order in multicellular systems
Project/Area Number 22111007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Hayashi Shigeo  国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (60183092)

Co-Investigator(Renkei-kenkyūsha) HONDA HISAO  神戸大学, 医学研究科, 研究員 (10289118)
Project Period (FY) 2010-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥51,740,000 (Direct Cost: ¥39,800,000、Indirect Cost: ¥11,940,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords細胞生物学 / 形態形成 / 上皮 / イメージング / 力学 / 遺伝学 / ショウジョウバエ / 細胞外基質 / 管腔形成 / 陥入 / Drosophila / 気管 / 細胞分裂 / 定量生物学 / 細胞運動 / 細胞骨格 / ライブイメージング / シミュレーション
Outline of Final Research Achievements

We studied the mechanical basis of epithelial movement and its interaction with extracellular environment. Our main research focus is the tracheal system in the Drosophila embryo, a network of tubular epithelium used as a respiratory organ. Epithelium is stabilized by cell-cell adhesion and cell-matrix adhesion. Breaking this stability is essential for initiating morphogenetic movement. We found that prospective tracheal primordium is under negative tension (pressurized). Anisotropic redistribution of tissue tension and timely mitosis initiates local mechanical instability that leads to tissue invagination movement. We also studied the tube lumen size control and found that extracellular matrix in the luminal space coordinates random movement of individual tubule cells to form coherent tissue architecture.

Report

(6 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (87 results)

All 2016 2015 2014 2013 2012 2011 2010 Other

All Int'l Joint Research (3 results) Journal Article (23 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 23 results,  Open Access: 7 results,  Acknowledgement Compliant: 6 results) Presentation (52 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Remarks (9 results)

  • [Int'l Joint Research] キュリー研究所(フランス)

    • Related Report
      2014 Annual Research Report
  • [Int'l Joint Research] ベングリオン大学(イスラエル)

    • Related Report
      2014 Annual Research Report
  • [Int'l Joint Research] 青島海洋大学(中国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Microtubule-dependent balanced cell contraction and luminal-matrix modification accelerate epithelial tube fusion.2016

    • Author(s)
      Kato, K., Dong, B., Wada, H., Tanaka-Matakatsu, M., Yagi, Y., Hayashi, S.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 000-000

    • DOI

      10.1038/ncomms11141

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes.2015

    • Author(s)
      Hanezzo E., Dong B., Recho P., Joanny J-F., Hayashi S.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 112 Issue: 28 Pages: 8211-8625

    • DOI

      10.1073/pnas.1504762112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Transport and retention mechanism for the sustained distal localization of Spn-F/ IKKε during Drosophila bristle elongation.2015

    • Author(s)
      Otani T., Oshima K., Kimpara A., Takeda M., Abdu U., Hayashi S.
    • Journal Title

      Development

      Volume: 142 Pages: 2338-2351

    • DOI

      10.1242/dev.121863

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Shaping of biological tubes by mechanical interaction of cell and extracellular matrix.2015

    • Author(s)
      Dong B., Hayashi S.
    • Journal Title

      Current Opinion in Genetics & Development

      Volume: 32 Pages: 129-134

    • DOI

      10.1016/j.gde.2015.02.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanisms of cell height changes that mediate epithelial invagination.2015

    • Author(s)
      Kondo T., Hayashi S.
    • Journal Title

      Develp. Growth and Diff.

      Volume: 57 Issue: 4 Pages: 313-323

    • DOI

      10.1111/dgd.12224

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TALEN-induced gene knock out in Drosophila.2014

    • Author(s)
      Kondo T
    • Journal Title

      Development Growth and Differentiation

      Volume: 56:1 Issue: 1 Pages: 86-91

    • DOI

      10.1111/dgd.12097

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Balance between Apical Membrane Growth and Luminal Matrix Resistance Determines Epithelial Tubule Shape.2014

    • Author(s)
      Dong B, Hannezo E, Hayashi S
    • Journal Title

      Cell Reports

      Volume: (14)00263-0 Issue: 4 Pages: 1-10

    • DOI

      10.1016/j.celrep.2014.03.066

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficient TALEN construction and evaluation methods for human cell and animal applications.2013

    • Author(s)
      Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
    • Journal Title

      Genes to Cells

      Volume: (In press) Issue: 4 Pages: 315-326

    • DOI

      10.1111/gtc.12037

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeogenetic inductive mechanism of segmentation in polychaete tail regeneration.2013

    • Author(s)
      Niwa N
    • Journal Title

      Developmental Biology

      Volume: 381: 2 Issue: 2 Pages: 460-470

    • DOI

      10.1016/j.ydbio.2013.04.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding.2013

    • Author(s)
      Okamoto M, Namba T, Shinoda T, Kondo T, Watanabe T, Inoue Y, Takeuchi K, Enomoto Y, Ota K, Oda K, Wada Y, Sagou K, Saito K, Sakakibara A, Kawaguchi A, Nakajima K, Adachi T, Fujimori T, Ueda M, Hayashi S, Kaibuchi K, Miyata T
    • Journal Title

      Nature Neuroscience

      Volume: 16 Issue: 11 Pages: 1556-66

    • DOI

      10.1038/nn.3525

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drosophila oocyte polarity and cytoskeleton organization requires regulation of Ik2 activity by Spn-F and Javelin-like.2013

    • Author(s)
      Amsalem S
    • Journal Title

      Molecular and Cellular Biology

      Volume: 33:22 Issue: 22 Pages: 4371-4380

    • DOI

      10.1128/mcb.00713-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab9 and retromer regulates retrograde trafficking of luminal protein required for epithelial tube length control2013

    • Author(s)
      Bo Dong, Ken Kakihara, Tetsuhisa Otani, Housei Wada and Shigeo Hayashi
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1358-1358

    • DOI

      10.1038/ncomms2347

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitotic cell rounding accelerates epithelial invagination2013

    • Author(s)
      Kondo T
    • Journal Title

      Nature

      Volume: 494 Issue: 7435 Pages: 125-129

    • DOI

      10.1038/nature11792

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab11-FIP3 is a cell cycle-regulated phosphoprotein.2012

    • Author(s)
      Collins L
    • Journal Title

      BMC Cell Biology

      Volume: 13:4 Issue: 1 Pages: 1-15

    • DOI

      10.1186/1471-2121-13-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ebi/AP-1 suppresses pro-apoptotic gene expression and permits long-term survival of Drosophila sensory neurons.2012

    • Author(s)
      Lim Young-Mi
    • Journal Title

      PLOS ONE

      Volume: 7 Issue: 5 Pages: e37028-e37028

    • DOI

      10.1371/journal.pone.0037028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondria-driven cell elongation mechanism for competing sperms2012

    • Author(s)
      Tatsuhiko Noguchi, Michiko Koizumi, Shigeo Hayashi
    • Journal Title

      Fly Journal

      Volume: 6 Issue: 2 Pages: 113-116

    • DOI

      10.4161/fly.19862

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained elongation of sperm tail promoted by local remodeling of giant mitochondria in Drosophila2011

    • Author(s)
      Noguchi T, Koizumi M, Hayashi S
    • Journal Title

      Curr Biol

      Volume: 21 Issue: 10 Pages: 805-814

    • DOI

      10.1016/j.cub.2011.04.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Joint morphology in the insect leg : evolutionary history inferred from Notch loss-of-function phenotypes in Drosophila2011

    • Author(s)
      Tajiri R, Misaki K, Yonenura S, Hayashi, S
    • Journal Title

      Development

      Volume: 138 Issue: 21 Pages: 4621-4626

    • DOI

      10.1242/dev.067330

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust specification of sensory neurons by dual functions of Charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy2011

    • Author(s)
      Yamasaki, Y., Lim, YM., Hayashi, S., Tsuda, L
    • Journal Title

      Genes to Cell

      Volume: 16 Issue: 8 Pages: 896-896

    • DOI

      10.1111/j.1365-2443.2011.01537.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IKKε regulates cell elongation through recycling endosome shuttling2011

    • Author(s)
      Tetsuhisa Otani
    • Journal Title

      Developmental Cell

      Volume: 20 Pages: 219-232

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin of the insect wing via integration of two developmental modules.2010

    • Author(s)
      Nao Niwa
    • Journal Title

      Evolution & Development

      Volume: 12 Pages: 168-176

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic intracellular distribution of Notch during activation and asymmetric cell division revealed by functional fluorescent fusion proteins.2010

    • Author(s)
      Koji Kawahashi
    • Journal Title

      Genes to Cells

      Volume: 15 Pages: 749-759

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg.2010

    • Author(s)
      Reiko Tajiri
    • Journal Title

      Development

      Volume: 137 Pages: 2055-2063

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genetic and physical mechanisms behind tube geometry and size control2016

    • Author(s)
      林 茂生
    • Organizer
      CDB Symposium 2016 “Size in Development: Growth, Shape and Allometry”
    • Place of Presentation
      理化学研究所、兵庫県、神戸市
    • Year and Date
      2016-03-28
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Transport and retention mechanism for the sustained distal organizer localization during Drosophila bristle elongateion2015

    • Author(s)
      林 茂生
    • Organizer
      Asian-Pacific Developmental Biology Conference,
    • Place of Presentation
      Xian China
    • Year and Date
      2015-09-12
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell extrusion from epithelia undergoing morphogenetic movement2015

    • Author(s)
      林 茂生
    • Organizer
      1st International Symposium on Cell Competition, “Cell Competition in Development and Cancer”
    • Place of Presentation
      芝蘭会館、京都府、京都市
    • Year and Date
      2015-09-10
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of apical extracellular matrix in epithelial tube morphogenesis2015

    • Author(s)
      林 茂生
    • Organizer
      Asian-Pacific Drosophila Conference,
    • Place of Presentation
      Beijin, China
    • Year and Date
      2015-05-13
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ショウジョウバエ気管原基における陥入過程の形態学的定量解析2014

    • Author(s)
      Hayashi S
    • Organizer
      動く細胞と場のクロストークによる秩序の生成, 第八回領域班会議
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Shaping Epithelial Sheet into Three-dimensional Organ.2013

    • Author(s)
      Hayashi S
    • Organizer
      The 23rd CDB Meeting Building multicellular systems from Cellular Cross-Talk
    • Place of Presentation
      神戸市
    • Year and Date
      2013-01-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of mitotic cell rounding and mechanical instability in epithelial morphogenesis2013

    • Author(s)
      Hayashi S
    • Organizer
      The 2nd Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Annual Research Report
  • [Presentation] A self-sustaining signaling center controls cell elongation2013

    • Author(s)
      Otani T
    • Organizer
      The 2nd Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanical coupling of apical membrane and luminal matrix shapes tracheal tube geometry in Drosophila2013

    • Author(s)
      Dong B
    • Organizer
      第46回日本発生生物学会大会
    • Place of Presentation
      松江市
    • Related Report
      2013 Annual Research Report
  • [Presentation] IKKe antagonizes PKC-dependent inhibitory phosphorylation of Singed/Fascin to promote2013

    • Author(s)
      Otani T
    • Organizer
      第46回日本発生生物学会大会
    • Place of Presentation
      松江市
    • Related Report
      2013 Annual Research Report
  • [Presentation] A self-sustaining signaling center controls cell elongation2013

    • Author(s)
      Otani T
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode2013

    • Author(s)
      Kondo T
    • Organizer
      The 17th International Congress of Developmental Biology
    • Place of Presentation
      カンクン、メキシコ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上皮構造の局所的不安定化による形態形成の制御2013

    • Author(s)
      Hayashi S
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Apical extracellular matrix and its coupling with mebrane shape tracheal tube geometry in Drosophila2013

    • Author(s)
      Dong B
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] A self-sustaining signaling center controls cell elongation2013

    • Author(s)
      Otani T
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synergistic action of mitosis and cell shape change in epithelial invagination2013

    • Author(s)
      Hayashi S
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞外マトリクスとアピカル細胞膜のカップリングが気管上皮チューブの形状を決定する2013

    • Author(s)
      Hayashi S
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上皮形態形成と分裂期ダイナミクス2013

    • Author(s)
      Kondo T
    • Organizer
      日本発生生物学会 2013年秋期シンポジウム
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cellular logic behind organ shape specification2013

    • Author(s)
      Hayashi S
    • Organizer
      大阪大学蛋白質研究所セミナー 細胞が集団になって初めて発現する機能
    • Place of Presentation
      大阪市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 細胞外マトリクスとアピカル細胞膜のカップリングが気管上皮チューブの形状を決定する2013

    • Author(s)
      Hayashi S
    • Organizer
      第36回日本分子生物学会年会ワークショップ
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] IKKε Promotes Paracrystalline Actin Bundle Assembly by Protecting Singed/Fascin from PKC(2W6III-7) dependent Inhibitory Phosphorylation2012

    • Author(s)
      Otani T
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Active role of mitotic cell rounding in epithelial morphogenesis.2012

    • Author(s)
      Hayashi S
    • Organizer
      Swiss Japanese Develomental Biology Meeting
    • Place of Presentation
      京都市
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Homeogenetic mechanism of segment regeneration in polychaete.2012

    • Author(s)
      Hayashi S
    • Organizer
      Asia-Pacific Developmental Biology Conference
    • Place of Presentation
      台湾
    • Year and Date
      2012-10-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発生を司る細胞と組織の力2012

    • Author(s)
      Hayashi S
    • Organizer
      第4回シグナルネットワーク研究会
    • Place of Presentation
      吹田市
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Connecting tubes into a network: role of microtubule in balanced cell contraction and adhesion in newly forming cell interface of Drosophila trachea.2012

    • Author(s)
      Hayashi S
    • Organizer
      The joint meeting of the British Societies for Cell and Developmental Biology and the Japanese Society for Developmental Biologists
    • Place of Presentation
      イギリス
    • Year and Date
      2012-04-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cell and tissue morphogenesis in Drosophila2012

    • Author(s)
      林茂生
    • Organizer
      India-Japan Workshop
    • Place of Presentation
      バンガロール、インド(招待講演)
    • Year and Date
      2012-01-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mitochondria-driven cell elongation mechanism for sperm morphogenesis.2012

    • Author(s)
      Noguchi T
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynamic Organization of Paracrystalline Actin Bundles by IKKepsilon.2012

    • Author(s)
      Otani T
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode.2012

    • Author(s)
      Kondo T
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Retromer and small GTPase-dependent recycling luminal protein controls apical ECM organization and epithelial tube size.2012

    • Author(s)
      Dong B
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Homeogenetic mechanism of sequential segmentation in polychaete.2012

    • Author(s)
      Niwa N
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Microtubule dependent cell shape change required for epithelial tubule connection.2012

    • Author(s)
      Kato K
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantitative Measurement of Cellular Dynamics of Drosophila Tracheal Invagination.2012

    • Author(s)
      Maeda T
    • Organizer
      第45回日本発生生物学会(細胞生物学会合同大会)
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation.2012

    • Author(s)
      Otani T
    • Organizer
      第十回日本ショウジョウバエ研究会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Morphometric analysis of tracheal placode invagination2012

    • Author(s)
      Kato K
    • Organizer
      第十回日本ショウジョウバエ研究会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mitotic cell rounding accelerates epithelial invagination.2012

    • Author(s)
      Kondo T
    • Organizer
      第十回日本ショウジョウバエ研究会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] IKKepsilonはFascin/SingedをPKCによるリン酸化から保護することによってアクチンの束化を促進する2011

    • Author(s)
      大谷哲久
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      近藤武史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regeneration of Polychaete Annellide, Perinereis nuntia Suggests a Homeogenetic Mechanisms of Sequential Segmentation Involving Wingless2011

    • Author(s)
      林茂生
    • Organizer
      The 21st CDB Meeting The 1st CDB-Regeneration Biology Study Group meeting "from Regeneration Biology to Regenerative Medicine (I)"
    • Place of Presentation
      神戸市
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imaging and quantitative approaches or the study of epithelial morphogenesis in Drosophila2011

    • Author(s)
      林茂生
    • Organizer
      RIKEN-Taiwan National Science Council Workshop on Biomedical Imaging and Image Processing
    • Place of Presentation
      神戸市(招待講演)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Force coupling in three-dimensional epithelial morphogenesis in Drosophila2011

    • Author(s)
      林茂生
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      姫路市(招待講演)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] エンドソームシャトリングによる細胞成長の制御2011

    • Author(s)
      林茂生
    • Organizer
      第5回膜生物学グローバルCOE研究討論会
    • Place of Presentation
      淡路市(招待講演)
    • Year and Date
      2011-07-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode/分裂期進入に伴う細胞球形化がショウジョウバエ胚気管原基の陥入を促進する2011

    • Author(s)
      近藤武史
    • Organizer
      第44回日本発生生物学会
    • Place of Presentation
      宜野湾市
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] IKKε regulates recycling endosome shuttling by phosphorylation of Nuf/Rad11FIP3.2010

    • Author(s)
      大谷哲久
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Joint structure in the insect leg : development, evolution and Notch-mediated regulation2010

    • Author(s)
      田尻怜子
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation and function of Notch endosomal trafficking2010

    • Author(s)
      林茂生
    • Organizer
      第5回Notch研究会
    • Place of Presentation
      東京都
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Joint structure in the insect leg : development, evolution and Notch-mediated regulation2010

    • Author(s)
      田尻怜子
    • Organizer
      第5回Notch研究会
    • Place of Presentation
      東京都
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coordination of Planar and Apico-Basal Forces during Invagination of Epithelial Placode.2010

    • Author(s)
      林茂生
    • Organizer
      ASCB/JSCB/Riken CDB Meeting
    • Place of Presentation
      京都市
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ECM産生細胞の形状変化が司る骨格の形態形成:ハエ成虫肢のBall-and-socket型間接2010

    • Author(s)
      田尻怜子
    • Organizer
      日本発生生物学会 夏季シンポジウム2010
    • Place of Presentation
      東京都
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節で向かい合う骨格の二面がぴったりと嵌り合う仕組み-昆虫の肢の発生学と比較形態学-2010

    • Author(s)
      田尻怜子
    • Organizer
      日本進化学会第12回東京大会
    • Place of Presentation
      東京都
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] IKKε regulates recycling endosome shuttling by phosphorylation of Nuf/Rad11FIP3.2010

    • Author(s)
      大谷哲久
    • Organizer
      札幌国際がんシンポジウム2010
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Milton/dMiro mediated morphogenesis of giant mitochondria shapes extremely long sperm tails of Drosophila.2010

    • Author(s)
      野口立彦
    • Organizer
      第43回日本発生生物学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Remarks] 細胞をドーナツ型に変形させる力の源 -上皮細胞のトポロジーを変換するメカニズムを解明-

    • URL

      http://www.riken.jp/pr/press/2016/20160421_1/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 細胞伸長の司令塔を配置する仕組みを解明 -細胞内の物流システムの調節に新たな知見-

    • URL

      http://www.riken.jp/pr/press/2015/20150623_1/

    • Related Report
      2014 Annual Research Report
  • [Remarks] ドーナツ型?!奇抜な細胞の形態変化を可能にする仕組み

    • URL

      http://www.cdb.riken.jp/news/2016/researches/0421_10621.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 細胞伸長の司令塔分子を正しく配置するメカニズム

    • URL

      http://www.cdb.riken.jp/news/2015/researches/0702_8397.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] アクチン繊維の自己組織化が管の形を整える

    • URL

      http://www.cdb.riken.jp/news/2015/researches/0625_8201.html

    • Related Report
      2014 Annual Research Report
  • [Remarks]

    • URL

      http://www.riken.jp/r-world/research/lab/cdb/mor/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cdb.riken.jp/jp/02_research/0201_core06.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cdb.riken.jp/signal/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cdb.riken.jp/signal/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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