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The intrinsic regulatory system of tumor vascularization

Planned Research

Project AreaIntegrative Research on Cancer Microenvironment Network
Project/Area Number 22112006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

SATO Yasufumi  東北大学, 加齢医学研究所, 教授 (50178779)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥114,790,000 (Direct Cost: ¥88,300,000、Indirect Cost: ¥26,490,000)
Fiscal Year 2014: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2013: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2012: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2011: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2010: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Keywordsvasohibin-1 / vasohibin-2 / 血管内皮細胞 / 血管新生 / がん細胞 / がん転移 / VASH1A / VASH1B / 血管成熟化 / 低酸素領域 / 低酸素 / VASH1 / αチューブリン脱チロシン化 / 受容体internalization / SOD2 / SIRT1 / αチューブリン / 脱チロシン化 / 受容体の細胞内移動 / Human Protein Maicroarray / カルパイン / VASH2 / GATA-2 / 内皮細胞 / microRNA
Outline of Final Research Achievements

Vasohibin-1 (VASH1) is an angiogenesis inhibitor expressed in endothelial cells, and the defect of its expression in ECs results in the enhancement of hematogenous and lymphatic cancer metastasis. There are 2 VASH1 proteins, a full length VASH1A and a splicing variant VASH1B. VASH1A causes angiogenesis inhibition and vascular maturation, whereas VASH1B causes endothelial cell death and vascular regression. Vasohibin-2 (VASH2) is an angiogenesis stimulator expressed in cancer cells, and the inhibition of its expression is useful for the anti-cancer treatment. VASH1 and VASH2 are highly conserved and resemble proteins. We analogized their active sites, developed neutralizing antibodies and identified a VASH receptor candidate.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (20 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] Enhanced cancer metastasis in mice deficient in vasohibin-1 gene.2013

    • Author(s)
      Ito S, Miyashita H, Suzuki Y, Kobayashi M, Satomi S, Sato Y.
    • Journal Title

      PLoS One

      Volume: 16

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer.2013

    • Author(s)
      Koyanagi T, Suzuki Y, Saga Y, Machida S, Takei Y, Fujiwara H, Suzuki M, Sato Y.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 12 Pages: 1705-1710

    • DOI

      10.1111/cas.12297

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasohibin-1 is a new predictor of disease-free survival in operated patients with renal cell carcinoma.2013

    • Author(s)
      Kanomata N
    • Journal Title

      J Clin Pathol.

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proliferation and maturation of intratumoral blood vessels in non-small cell lung cancer.2013

    • Author(s)
      Yazdani S
    • Journal Title

      Hum Pathol.

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1.2012

    • Author(s)
      Miyashita H
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma.2012

    • Author(s)
      Miyazaki Y
    • Journal Title

      Clin Cancer Res.

      Volume: 18 Pages: 4145-4153

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Vasohibin Family: Novel Regulators of Angiogenesis.2012

    • Author(s)
      Sato Y
    • Journal Title

      Vascular Pharmacology

      Volume: 56 Pages: 262-266

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Vasohibin Family : Novel Regulators of Angiogenesis2012

    • Author(s)
      Sato Y
    • Journal Title

      Vascular Pharmacology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis2011

    • Author(s)
      Saito D, Maeshima Y, Nasu T, Yamasaki H, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H
    • Journal Title

      Am.J.Phys-Renal Physiol

      Volume: 300

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutual Balance between Vasohibin-1 and Soluble VEGFR-1 in Endothelial Cells2011

    • Author(s)
      Miyashita H, Suzuki H, Ohkuchi A, Sato Y
    • Journal Title

      Pharmaceuticals

      Volume: 4 Pages: 1551-1577

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas2011

    • Author(s)
      Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 446-451

    • NAID

      10029290441

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy2011

    • Author(s)
      Sato Y
    • Journal Title

      Cancer Sci.

      Volume: (in press)

    • NAID

      10029294854

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast2010

    • Author(s)
      Tamaki K, Sasano H, Maruo Y, Takahashi Y, Miyashita M, Moriya T, Sato Y, Hirakawa H, Tamaki N, Watanabe M, Ishida T, Ohuchi N
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 1051-1058

    • NAID

      10026591529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion2010

    • Author(s)
      Suzuki Y, Kobayashi M, Miyashita H, Ohta H, Sonoda H, Sato Y
    • Journal Title

      J.Cell Sci.

      Volume: 123 Pages: 3094-3101

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Distinctive roles of Vasohibin-1A and Vasohibin-1B in angiogenesis regulation.2014

    • Author(s)
      Sachiko H, Yasuhiro S, Miho K, Sato Y
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Application of vasohibin family to angiogenesis regulation.2014

    • Author(s)
      Sato Y
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Vasohibin-1による微小管の翻訳後修飾を介したVEGFシグナル伝達の新規抑制機構2013

    • Author(s)
      小林美穂、鈴木康弘、佐藤靖史
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] asohibin-1は血管内皮細胞の微小管の翻訳後修飾を介してVEGFシグナル伝達を制御する.2012

    • Author(s)
      小林美穂
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of vasohibin family in tumor angiogenesis.2012

    • Author(s)
      Sato Y
    • Organizer
      AVBS 20th Annual Scientific Meeting
    • Place of Presentation
      Gold Coast, Australia
    • Year and Date
      2012-09-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The role of vasohibin family in tumor angiogenesis.2012

    • Author(s)
      Sato Y
    • Organizer
      17th International Vascular Biology Meeting
    • Place of Presentation
      Wiesbaden, Germany
    • Year and Date
      2012-06-02
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Vasohibinファミリーを応用したがん治療法の開発研究2012

    • Author(s)
      佐藤靖史
    • Organizer
      第3次対がん10か年総合戦略(平成16年~25年度)文部科学省新学術領域研究「がん研究分野の特性等を踏まえた支援活動」合同公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-01-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] がんを血管から治療する2012

    • Author(s)
      佐藤靖史
    • Organizer
      平成23年度北海道大学公開シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2012-01-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Proteolytic cleavage of secreted Vasohibin-1 by cancer cells2011

    • Author(s)
      齋藤恵、鈴木康弘、佐藤靖史
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] がんを脈管から治療する2011

    • Author(s)
      佐藤靖史
    • Organizer
      第70回日本癌学会学術集会モーニングレクチャー
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌細胞へのVasohibin-1遺伝子一過性導入によるparadoxicalな血管新生促進2011

    • Author(s)
      中村崇宣、佐藤靖史
    • Organizer
      第70回日本癌学会学術集会モーニングレクチャー
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of vasohibin family in the regulation of tumor angiogenesis2011

    • Author(s)
      Sato Y
    • Organizer
      6^<th> European Meeting for Vascular Biology and Medicine
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍血管新生の内因性調節機構2011

    • Author(s)
      佐藤靖史
    • Organizer
      がん微小環境ネットワークの統合的研究第一回公開ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管新生とリンパ管新生の調節機構2010

    • Author(s)
      佐藤靖史
    • Organizer
      第10回リンパ微小循環研究会
    • Place of Presentation
      大分
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生抑制とがん2010

    • Author(s)
      佐藤靖史
    • Organizer
      第69回日本癌学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生ネガティブフィードバック調節因子バソヒビン-1による卵巣癌分子標的・遺伝子治療2010

    • Author(s)
      嵯峨泰、高橋詳史、竹井裕二、町田静生、鈴木光明、佐藤靖史
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] A system for the termination of angiogenesis2010

    • Author(s)
      佐藤靖史
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内皮ストレス耐性におけるsplicing variant vasohibin-1の意義2010

    • Author(s)
      宮下浩輝、佐藤靖史
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] VasohibinはVEGFシグナル遮断による内皮細胞障害を防止する2010

    • Author(s)
      林英樹、宮下浩輝、鈴木康弘、小林美穂、佐藤靖史
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写囚子GATA-2によるVasohibin-1遺伝子の発現調節2010

    • Author(s)
      鈴木康弘、神吉康晴、南敬、佐藤靖史
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Book] Angiogenesis and Vascularisation2014

    • Author(s)
      Sato Y.
    • Total Pages
      416
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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