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Neural circuits underlying sensory association functions in mice

Planned Research

Project AreaMesoscopic neurocircuitry: towards understanding of the functional and structural basis of brain information processing
Project/Area Number 22115011
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNiigata University

Principal Investigator

SHIBUKI Katsuei  新潟大学, 脳研究所, 教授 (40146163)

Co-Investigator(Renkei-kenkyūsha) HISHIDA Ryuichi  新潟大学, 脳研究所, 准教授 (90313551)
TOHMI Manavu  新潟大学, 脳研究所, 助教 (10401770)
TSUKANO Hiroaki  新潟大学, 脳研究所, 助教 (90624338)
WATANABE Kenji  新潟大学, 脳研究所, 特任助教 (80609272)
YOSHITAKE Kohei  新潟大学, 脳研究所, 特任助教 (60649218)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥88,270,000 (Direct Cost: ¥67,900,000、Indirect Cost: ¥20,370,000)
Fiscal Year 2014: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2013: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2012: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2010: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Keywords感覚連合野 / 高次視覚野 / 短期記憶 / 細胞接着因子 / マウス / 光学的機能イメージング / 行動解析 / 視覚野 / 体性感覚野 / 聴覚野 / 空間認知 / 形状認知 / プリズム眼鏡 / 後部頭頂連合野 / 経験依存的可塑性 / 視覚野脳地図 / プロトカドヘリン / 空間不一致 / 和音 / Missing Fo / 2段階音弁別試験
Outline of Final Research Achievements

The posterior parietal cortex (PPC) is a part of the higher visual cortices in the dorsal pathway. We found that PPC was responsible for the integration of spatial information obtained from the eyes and whiskers in mice. PPC was also responsible for short-term memory of visual spatial information. In contrast, higher visual cortices in the ventral pathway were responsible for short-term memory of shape information, and for the integration of visual and auditory information. These functions were dependent on clustered protocadherin alpha, neuro-specific cell adhesion molecules. It is suggested that common neural circuits, dependent on clustered protocadherins, work as short-term memory circuits to achieve these functions. The sensory information, kept as sustained neural activities in the circuits, is likely to induce related neural activities in the wide brain areas connected with higher visual cortices. The activity complex may be regarded as the neural correlate of visual awareness.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(28 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Invited: 2 results) Remarks (3 results)

  • [Journal Article] Spinal mechanisms underlying potentiation of hindpaw responses observed after transient hindpaw ischemia in mice.2015

    • Author(s)
      Watanabe T, Sasaki M, Komagata S, Tsukano H, Hishida R, Kohno T, Baba H, Shibuki K
    • Journal Title

      Scientific Reports

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Delineation of a frequency-organized region isolated from the mouse primary auditory cortex.2015

    • Author(s)
      Tsukano H, Horie M, Bo T, Uchimura A, Hishida R, Kudoh M, Takahashi K, Takebayashi H, Shibuki K
    • Journal Title

      J Neurophysiol

      Volume: 印刷中 Issue: 7 Pages: 2900-2920

    • DOI

      10.1152/jn.00932.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mpaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice.2015

    • Author(s)
      Meguro R, Hishida R, Tsukano H, Yoshitake K, Imamura R, Tohmi M, Kitsukawa T, Hirabayashi T, Yagi T, Takebayashi H, Shibuki K
    • Journal Title

      J Neurochem

      Volume: 133 Issue: 1 Pages: 66-72

    • DOI

      10.1111/jnc.13053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multimodal cortical sensory pathways revealed by sequential transcranial electrical stimulation in mice.2014

    • Author(s)
      Hishida R, Kudoh M, Shibuki K
    • Journal Title

      Neurosci Re

      Volume: 8 Pages: 49-55

    • DOI

      10.1016/j.neures.2014.07.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The extrageniculate visual pathway generates distinct response properties in the higher visual areas of mice2014

    • Author(s)
      Tohmi M, Meguro R, Tsukano H, Hishida R, Shibuki K
    • Journal Title

      Current Biology

      Volume: 24 Issue: 6 Pages: 587-597

    • DOI

      10.1016/j.cub.2014.01.061

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual map shifts based on whisker-guided cues in the young mouse visual cortex2013

    • Author(s)
      Yoshitake K, Tsukano H, Tohmi M, Komagata S, Hishida R, Yagi T, Shibuki K
    • Journal Title

      Cell Reports

      Volume: 5 Issue: 5 Pages: 1365-1374

    • DOI

      10.1016/j.celrep.2013.11.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related deterioration of cortical responses to slow FM sounds in the auditory belt region of adult C57BL/6 mice2013

    • Author(s)
      Tsukano H, Horie M, Honma Y, Ohga S, Hishida R, Takebayashi H, Takahashi S, Shibuki K
    • Journal Title

      Neurosci Lett

      Volume: 556 Pages: 204-209

    • DOI

      10.1016/j.neulet.2013.10.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory cortical areas activated by slow frequency-modulated sounds in mice2013

    • Author(s)
      Honma Y, Tsukano H, Horie M, Ohshima S, Tohmi M, Kubota Y, Takahashi K, Hishida R, Takahashi S, Shibuki K
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 7 Pages: e68113-e68113

    • DOI

      10.1371/journal.pone.0068113

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual compartments of the ventral division of the medial geniculate body projecting to the core region of the auditory cortex in C57BL/6 mice2013

    • Author(s)
      Horie M, Tsukano H, Hishida R, Takebayashi H, Shibuki K
    • Journal Title

      Neurosci Res

      Volume: 76 Issue: 4 Pages: 207-212

    • DOI

      10.1016/j.neures.2013.05.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic γ-aminobutyric acid receptors in mouse medial vestibular nuclear neurons.2013

    • Author(s)
      Todaka H
    • Journal Title

      Eur J Neurosci

      Volume: 37 Issue: 3 Pages: 339-350

    • DOI

      10.1111/ejn.12051

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periventricular nodular heterotopia functionally couples with the overlying hippocampus.2012

    • Author(s)
      Kitaura H
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 7 Pages: 127-131

    • DOI

      10.1111/j.1528-1167.2012.03509.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer2012

    • Author(s)
      Yamashita H
    • Journal Title

      PLoS One

      Volume: 7 Issue: 4 Pages: e35676-e35676

    • DOI

      10.1371/journal.pone.0035676

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer2012

    • Author(s)
      Yamashita H, Shibuki K, 他8名
    • Journal Title

      PLoS ONE

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periventricular nodular heterotopia functionally couples with the overlying hippocampus2012

    • Author(s)
      Kitaura H, Shibuki K, 他8名
    • Journal Title

      Epilepsia

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal dynamics of epileptiform propagations : imaging of human brain slices2011

    • Author(s)
      Kitaura H, Shibuki K, 他11名
    • Journal Title

      Neuroimage

      Volume: 58 Pages: 50-59

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of virtual pitch up to 5 kHz by mice2011

    • Author(s)
      Tsukano H, Shibuki K, 他1名
    • Journal Title

      Neuroscience Research

      Volume: 71 Pages: 140-144

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial electrical stimulation of cortico-cortical connections in anesthetized mice2011

    • Author(s)
      Hishida R, Shibuki K, 他2名
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 201 Pages: 315-321

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Timing-dependent effects of whisker trimming in thalamocortical slices including the mouse barrel cortex.2011

    • Author(s)
      Watanabe K, Shibuki K, 他2名
    • Journal Title

      Brain Research

      Volume: 1385 Pages: 93-106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initial phase of neuropathic pain within a few hours after nerve injury in mice.2011

    • Author(s)
      Komagata S, Shibuki K, 他6名
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Pages: 4896-4905

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptive cortical responses during capsaicin-induced tactile allodynia in mice with spinal dorsal column lesioning.2011

    • Author(s)
      Komagata S, Shibuki K, 他3名
    • Journal Title

      Neuroscience Research

      Volume: 69 Pages: 348-351

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Visual object recognition based on short-term memory in mice2015

    • Author(s)
      Katsuei Shibuki
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-05-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウスの視覚記憶依存的タスクの神経基盤2014

    • Author(s)
      澁木 克栄
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウス高次視覚機能のフラビン蛋白蛍光イメージング2014

    • Author(s)
      澁木克栄
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] マクロ共焦点顕微鏡によるマウス脳活動イメージング2012

    • Author(s)
      澁木克栄
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Flavoprotein fluorescence imaging of cortical mass and single neuronal activities in mice2011

    • Author(s)
      澁木克栄
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Remarks] 脳内ブレ補正メカニズムの発見

    • URL

      http://www.bri.niigata-u.ac.jp/~physio/Yoshitake%20PR.pdf

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~physio/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.bri.niigata-u.ac.jp/~physio/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-22   Modified: 2019-07-29  

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