| Budget Amount *help |
¥125,450,000 (Direct Cost: ¥96,500,000、Indirect Cost: ¥28,950,000)
Fiscal Year 2014: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2013: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2012: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2011: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Outline of Final Research Achievements |
Post-translational modifications play critical roles in the regulation of signal transduction and cellular functions. Structural biology methods, including X-ray crystallography, are powerful tools for dissecting the molecular interaction mechanisms between the factors involved in these signaling pathways. Therefore, synergetic approaches by structural, molecular and cellular biology are important to understand both the mechanisms of signal transduction by post-translational modifications and their pathogenic dysregulation. Our results of the structural analyses of cGAS, A20-ZF7-linear ubiquitine complex, and HHM highlight the importance of synergetic approaches by collaborations between different biological fields.
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