| Budget Amount *help |
¥164,710,000 (Direct Cost: ¥126,700,000、Indirect Cost: ¥38,010,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2012: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Fiscal Year 2011: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
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| Outline of Final Research Achievements |
To elucidate mechanisms through which a hematopoietic stem cell differentiates to mature blood cells, myelodysplastic syndromes (MDS) may be a good material. We identified three responsible genes for the deletion of the long arm of chromosome 7, which is most frequently observed as a non-random chromosome abnormality in patients with MDS. Both the homo- and hetero-deficient mice of Samd9/Samd9L genes, which encode endosome proteins developed MDS at their advanced age, mimics human diseases. Lack of Miki, which encodes a centrosome protein prolongs prometaphase, resulting in abnormal morphology of nuclei, which strikingly resembles those routinely observed in bone marrow preparations of MDS patients. Those three genes located in chromosome 7 were considered to be responsible for the development of MDS.
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