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Studies on microenvironment that regulates hematopoietic cells

Planned Research

Project AreaMolecular mechanisms of cell fate determination in the cells that undergo stepwise differentiation to multiple pathways
Project/Area Number 22118006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

MIYAJIMA Atsushi  東京大学, 分子細胞生物学研究所, 教授 (50135232)

Co-Investigator(Renkei-kenkyūsha) 田中 稔  国際医療研究センター, 研究所, 室長 (80321909)
伊藤 暢  東京大学, 分子細胞生物学研究所, 准教授 (50396917)
榎本 豊  東京大学, 分子細胞生物学研究所, 助教 (20608210)
西條 栄子  東京大学, 分子細胞生物学研究所, 技術専門職員 (60376647)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥164,710,000 (Direct Cost: ¥126,700,000、Indirect Cost: ¥38,010,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2012: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Fiscal Year 2011: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
Keywords造血 / 免疫 / 肝臓 / 間葉系幹細胞 / サイトカイン / 肝細胞 / 骨髄 / 発生 / 幹細胞 / ニッチ / ニッシェ / 細胞分化
Outline of Final Research Achievements

The liver is a central organ for homeostasis by playing a major role for metabolism and also a tissue for immune response by holding various immune cells. In fetus, the liver functions as a major hematopoietic tissue, while hematopoieis occurs in the bone marrow in adult. In this study, we studied the environment that supports hematopoiesis in fetal liver and adult bone marrow and showed that the periphery of fetal liver functions as a niche for erythropoiesis and that Oncostatin M plays an important role for bone marrow hematopoiesis by regulating differentiation of bone marrow mesenchymal cells to adipocytes and osteoblasts. We also studied inflammation and regeneration of the liver and showed that M2 macrophages play a role for liver fibrosis induced by injury and that overexpression of IL-4 in the liver induced a novel class of NK cells with strong cytotoxic activity.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (57 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 2 results) Presentation (38 results) (of which Invited: 7 results)

  • [Journal Article] Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy.2015

    • Author(s)
      Inagaki N, Inagaki F, Kokudo N and Miyajima A.
    • Journal Title

      J. Hepatology, in press.

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive remodeling of the biliary architecture underlies liver homeostasis.2015

    • Author(s)
      Kaneko K, Kamimoto K, Miyajima A and Itoh T.
    • Journal Title

      Hepatology in press.

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular Basis of Liver Regeneration.2014

    • Author(s)
      Itoh T. and Miyajima A.
    • Journal Title

      Hepatology

      Volume: 59 Issue: 4 Pages: 1617-1626

    • DOI

      10.1002/hep.26753

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of OSMRb exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.2014

    • Author(s)
      Komori T, Tanaka M, Semba M, Miyajima A, and Morikawa Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 20 Pages: 13821-13837

    • DOI

      10.1074/jbc.m113.542399

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration.2014

    • Author(s)
      Yagai T, Miyajima A and Tanaka M.
    • Journal Title

      American J. Pathology Aug

      Volume: 184(8) Pages: 2250-2259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem/progenitor cells in liver development, homeostasis, regeneration and reprogramming.2014

    • Author(s)
      Miyajima A, Tanaka M, and Itoh T.
    • Journal Title

      Cell Stem Cell

      Volume: 14 Pages: 561-574

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mature resting Ly6Chigh natural killer cells can be reactivated by IL-15.2014

    • Author(s)
      Omi A, Enomoto Y, Kiniwa T, Miyata N and Miyajima A.
    • Journal Title

      Eur. J. Immunology. Sep

      Volume: 44(9) Issue: 9 Pages: 2638-47

    • DOI

      10.1002/eji.201444570

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by affecting adipogenesis and osteoblastogenesis.2014

    • Author(s)
      Sato F, Miyaoka Y, Miyajima A and Tanaka M.
    • Journal Title

      PLoS One 2014 Dec 31

      Volume: 9(12) Issue: 12 Pages: e116209-e116209

    • DOI

      10.1371/journal.pone.0116209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.2014

    • Author(s)
      Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, and Yamamoto M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 34 Issue: 5 Pages: 900-913

    • DOI

      10.1128/mcb.01384-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MiR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the Invasiveness of transformed cells.2013

    • Author(s)
      Gailhouste L., Gomez-Santos L., Kitagawa N., Kawaharada K., Tirion M., Kosaka N., Takahashi R., Shibata T., Miyajima A., and *Ochiya T.
    • Journal Title

      Hepatology

      Volume: 58(3) Pages: 1153-1165

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells.2013

    • Author(s)
      Inagaki F., Tanaka M., Inagaki N., Yagai T., Sato Y., Sekiguchi K., Oyaizu N., Kokudo N., and *Miyajima A.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 430 Pages: 751-756

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.2013

    • Author(s)
      Takase H., *Itoh T., Wang T., Koji T., Akira S., Takikawa Y., and Miyajima A.
    • Journal Title

      Genes and Development

      Volume: 27 Pages: 169-181

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.2013

    • Author(s)
      Komori D., Tanaka M., Senba E., Miyajima A. and *Morikawa Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 288(30) Pages: 21861-21875

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells2013

    • Author(s)
      Inagaki F., Tanaka M., Inagaki N., Yagai T., Sato Y., Sekiguchi K., Oyaizu N., Kokudo N., and Miyajima A
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 430 Issue: 2 Pages: 751-756

    • DOI

      10.1016/j.bbrc.2012.11.076

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.2013

    • Author(s)
      Takase HM, Itoh T, Ino S, Wang T, Koji T, Akira S, Takikawa Y, Miyajima A.
    • Journal Title

      Genes & Development

      Volume: 27 Issue: 2 Pages: 169-181

    • DOI

      10.1101/gad.204776.112

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration.2012

    • Author(s)
      Yuichiro Miyaoka
    • Journal Title

      Current Biology

      Volume: 22 Issue: 13 Pages: 1166-1175

    • DOI

      10.1016/j.cub.2012.05.016

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.2012

    • Author(s)
      Senga K., Mostov K. E., Mitaka T., Miyajima A., and Tanimizu N.
    • Journal Title

      Mol Biol. Cell

      Volume: 23 Issue: 15 Pages: 2845-2855

    • DOI

      10.1091/mbc.e12-02-0097

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α1- and α5-Containing laminins regulate the development of bile ducts via β1-integrin signals.2012

    • Author(s)
      Tanimizu N., Kikkawa Y., Mitaka T. and Miyajima A.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 34 Pages: 28586-28597

    • DOI

      10.1074/jbc.m112.350488

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver stem/progenitor cells : their characteristics and regulatory mechanisms2011

    • Author(s)
      Tanaka M, Itoh T, Tanimizu N, Miyajima A.
    • Journal Title

      J Biochem.

      Volume: 149 Pages: 231-239

    • NAID

      10030583627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Generation of functional pancreatic and liver tissues from iPS cells.2015

    • Author(s)
      Atsushi Miyajima
    • Organizer
      The 18th Takeda Science Foundation Symposium on Bioscience(第18回武田科学振興財団生命科学シンポジウム)
    • Place of Presentation
      武田薬品研修所(大阪府吹田市)
    • Year and Date
      2015-01-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オコスタチンMによるマウス肝繊維化促進機構の解析2014

    • Author(s)
      松田道隆、田中稔、宮島篤
    • Organizer
      第28回肝類洞壁細胞研究会学術集会
    • Place of Presentation
      アークホテル岡山(岡山県岡山市)
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Overexpression of IL-4 augments NK cell activities in vivo2014

    • Author(s)
      木庭乾、榎本豊、尾見歩惟、宮島篤
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Establishment of isolation and culture system of Based Biliary Tree Stem Progenitor Cell (BTSC) based on the expression profile of TROP2.2014

    • Author(s)
      松井理司、田中稔、宮島篤
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lutheranの発現を指標とした肝幹/前駆細胞の性状解析2014

    • Author(s)
      三浦 泰史、田中 稔、吉川 大和、合田 亘人、宮島 篤
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] iPS細胞から機能的肝組織の構築2014

    • Author(s)
      木戸丈友 、宮島篤
    • Organizer
      第59回人類遺伝学会・第21回遺伝子治療学会 シンポジウム「幹細胞を用いた肝臓の再生研究」
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of M2-like macrophages in liver fibrosis (肝繊維化に置けるM2様マクロファージの役割)2014

    • Author(s)
      Eiko SAIJO, Michitaka MATSUDA, Yutaka ENOMOTO, Minoru TANAKA, Atsushi MIYAJIMA
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Notch signaling promotes proliferation of adult liver progenitor cells and progenitor-dependent liver regeneration2014

    • Author(s)
      Tohru Itoh, Seitaro Ino, and Atsushi Miyajima
    • Organizer
      FASEB Summer Research Conferences / Liver Biology: Fundamental Mechanisms and Translational Applications
    • Place of Presentation
      Keystone Resort (U.S.A.)
    • Year and Date
      2014-07-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel visualization method reveals connection of adult liver progenitor cells to biliary trees in various liver injuries2014

    • Author(s)
      Kota Kaneko, Tohru Itoh, Atsushi Miyajima
    • Organizer
      FASEB Summer Research Conferences / Liver Biology: Fundamental Mechanisms and Translational Applications
    • Place of Presentation
      Keystone Resort (U.S.A.)
    • Year and Date
      2014-07-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanism of liver fibrosis induced by Oncostatin M2014

    • Author(s)
      松田道隆、田中稔、宮島篤
    • Organizer
      FASEB Summer Research Conferences / Liver Biology: Fundamental Mechanisms and Translational Applications
    • Place of Presentation
      Keystone Resort (U.S.A.)
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「iPS細胞の肝臓細胞および膵臓細胞への応用」2014

    • Author(s)
      宮島篤
    • Organizer
      第35回日本炎症・再生学会 シンポジウム「未来の再生医療」
    • Place of Presentation
      名護市万国津梁館 (沖縄県名護市)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of Oncostatin M in the Bone Marrow Microenvironment for Hematopoiesis2014

    • Author(s)
      佐藤郁、宮島篤
    • Organizer
      第12回幹細胞シンポジウム
    • Place of Presentation
      九州大学医学部 百年講堂(福岡県福岡市)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特別講演 「iPS細胞と肝疾患」2014

    • Author(s)
      宮島篤
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京都千代田区)
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Expression of Ly6C defines two subsets of mature NK cells2013

    • Author(s)
      Ai Omi, Tsuyoshi Kiniwa, Yutaka Enomoto, Atsushi Miyajima.
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2013-12-11
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝臓の障害・再生過程における胆管/肝前駆細胞系の3次元動態解析2013

    • Author(s)
      伊藤 暢、金子 洸太、神元 健児、勝又 廉、宮島 篤
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(神戸ポートアイランド)(兵庫県神戸市)
    • Year and Date
      2013-12-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of liver M2-like cells in liver fibrosis2013

    • Author(s)
      Eiko SAIJOU, Michitaka MATSUDA, Yutaka ENOMOTO, Minoru TANAKA, Atsushi MIYAJIMA
    • Organizer
      第20回肝細胞研究会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2013-09-27
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanism of liver fibrosis induced by Oncostatin M2013

    • Author(s)
      松田道隆 田中稔 宮島篤
    • Organizer
      第20回肝細胞研究会
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)(大阪府大阪市)
    • Year and Date
      2013-09-27
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel visualization method reveals connection of adult liver progenitor cells to biliary trees in various liver injuries2013

    • Author(s)
      金子洸太、伊藤暢、宮島篤
    • Organizer
      第20回肝細胞研究会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2013-09-26
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanism of liver fibrosis induced by Oncostatin M2013

    • Author(s)
      松田道隆 田中稔 中内啓光 宮島篤
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-09-13
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス成体肝における新規肝幹/前駆細胞マーカーの探索2013

    • Author(s)
      関口仁貴、田中稔、宮島篤
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-09-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規可視化法による肝再生過程の胆管系三次元組織構造の解析2013

    • Author(s)
      金子洸太、伊藤暢、宮島篤
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-09-11
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝細胞死から見た肝障害後の再生および線維化の制御機構2013

    • Author(s)
      田中稔、谷貝知樹、宮島篤
    • Organizer
      第86回日本生化学会シンポジウム「多様な細胞死を起点とする生体制御ネットワーク」
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-09-11
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression of Ly6C defines two subsets of mature NK cells2013

    • Author(s)
      Ai Omi, Tsuyoshi Kiniwa, Yutaka Enomoto, Atsushi Miyajima.
    • Organizer
      the 15th international congress of immunology P1.03.40、
    • Place of Presentation
      MiCo, Milano Congressi (Milano, Italy)
    • Year and Date
      2013-08-27
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liver stem cells in development and regeneration2013

    • Author(s)
      A.Miyajima
    • Organizer
      Asia Pacific Association of Study of Liver Disease
    • Place of Presentation
      Suntec (Singapore)
    • Year and Date
      2013-06-08
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] FGF7 is a functional niche signal required for stimulation of adult liver2013

    • Author(s)
      Tohru Itoh, Hinako Takase, Atsushi Miyajima
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, "Stem Cell Regulation in Homeostasis and Disease"
    • Place of Presentation
      Banff (Canada)
    • Year and Date
      2013-02-24
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] オンコスタチンMによる骨髄造血環境の制御機構の解明2012

    • Author(s)
      佐藤 郁、田中 稔、宮島 篤
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] オンコスタチンMはマクロファージのM1/M2バランスに作用しインスリン抵抗性を改善する2012

    • Author(s)
      田中稔、小森 忠祐、森川吉博、仙波恵美子、宮島篤
    • Organizer
      第85回 日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] 肝再生および肝線維化におけるSemaphorin 3Eの機能2012

    • Author(s)
      谷貝 知樹、田中 稔、宮島 篤
    • Organizer
      第85回生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] 肝臓の発生および代謝機能獲得におけるTribbles遺伝子の役割2012

    • Author(s)
      西條 栄子, 内木 隆, 宮島 篤
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Critical role of FGF7 for development of adult liver stem/progenitor cells and regeneration in damaged livers2012

    • Author(s)
      Tohru Itoh, Hinako Takase, Atsushi Miyajima
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Colorad (USA)
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cellular basis for liver regeneration2012

    • Author(s)
      A. Miyajima
    • Organizer
      Liver Metabolism, Diseases and Cancer
    • Place of Presentation
      Suzhou (China)
    • Year and Date
      2012-05-21
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] Role for stem/progenitor cells in liver regeneration2012

    • Author(s)
      A. Miyajima
    • Organizer
      First EHBH International Forum on Liver Biomarkers
    • Place of Presentation
      Shanghai (China)
    • Year and Date
      2012-04-26
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] Critical role of FGF7 for development of adult liver stem/progenitor cells and regeneration in damaged livers2012

    • Author(s)
      Tohru Itoh, Hinako Takase, Atsushi Miyajima
    • Organizer
      FASEB Summer Research Conference
    • Place of Presentation
      Colorado (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] オンコスタチンMによる骨髄造血環境の制御機構の解明(2012

    • Author(s)
      佐藤 郁、田中 稔、宮島 篤
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝臓の発生および代謝機能獲得におけるTribbles遺伝子の役割2012

    • Author(s)
      西條 栄子, 内木 隆, 宮島 篤
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of fetal liver cells contributing to hematopoiesis during mouse embryogenesis2010

    • Author(s)
      Tanaka M., Motomura M., Kamiya Y., Miyajima A.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass Village Conference Center, Co, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of fetal liver cells contributing to hematopoiesis during mouse embryogenesis2010

    • Author(s)
      Tanaka M., Motomura M., Kamiya Y., Miyajima A.
    • Organizer
      BMB2010/第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification and characterization of a new IkappaB protein2010

    • Author(s)
      Yamauchi S., Ito H., Omi A., Miyajima A.
    • Organizer
      BMB2010/第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2018-03-28  

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