| Budget Amount *help |
¥127,790,000 (Direct Cost: ¥98,300,000、Indirect Cost: ¥29,490,000)
Fiscal Year 2014: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2010: ¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
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| Outline of Final Research Achievements |
The mammalian neocortex consists with various types of neurons that forms specific neuronal networks. Production of these neurons requires proper maintenance and differentiation of neural progenitor cells. In this study, we focused on the function of Pax6 transcription factor and its downstream molecules. We found that a centrosomal protein ninein regulates nuclear movement of neural progenitor cells via anchoring to microtubles. We also revealed that Dmrta1 functions to induce Neurogenin2 that is critical for production of excitatory neurons within the developing neocortex. Furthermore, an axon guidance molecule plexin-A4 is observed to be expressed in the layer IV neurons not only of the somatosensory cortex but also of the visual cortex, suggesting that these neurons may regulate projection from the thalamus.
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