| Budget Amount *help |
¥106,080,000 (Direct Cost: ¥81,600,000、Indirect Cost: ¥24,480,000)
Fiscal Year 2014: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2013: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
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| Outline of Final Research Achievements |
We found that IL1-receptor accessory protein-like 1 (IL1RAPL1) responsible for intellectual disability and autism spectrum disorder and IL-1 receptor accessory protein (IL-1RAcP) mediate synapse formation of cortical neurons by interacting with presynaptic protein tyrosine phosphatase (PTP) δ. Correspondingly, spine densities of pyramidal neurons in the neocortex and hippocampus are decreased in IL1RAPL1 knockout mice. Furthermore, IL1RAPL1 knockout mice exhibited impairments of learning abilities in spatial reference and working memory tests and fear conditioning tests. We also showed that medium spiny neurons and dopamine D1 receptor in the striatum are required for the contextual fear conditioning.
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