| Budget Amount *help |
¥89,440,000 (Direct Cost: ¥68,800,000、Indirect Cost: ¥20,640,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2012: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2011: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2010: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Outline of Final Research Achievements |
To clarify the mechanism of limb regeneration that differs between mammals (non-regenerative) and amphibians (regenerative), responses to limb amputation were compared between mice and African clawed frogs. The frogs can form a regeneration blastema that eventually develops into a lost part of the amputated limb, although mice cannot. In mice, however, cartilaginous calluses are formed around the cut edge of the amputated bones in the limb stump; and the amputation surface is covered by the wound epidermis rapidly in certain conditions, both of which occur and are thought to be important for limb regeneration in amphibians. On the other hand, the wound epidermis is well-innervated in the frogs, but the one in mice is not. Since blastema formation is nerve-dependent, whether or not nerves can interact with the wound epidermis might be one of the key processes to separate successful nerve-dependent blastema formation in the frogs and failure in mice.
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