|Budget Amount *help
¥261,430,000 (Direct Cost: ¥201,100,000、Indirect Cost: ¥60,330,000)
Fiscal Year 2014: ¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2013: ¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2012: ¥50,310,000 (Direct Cost: ¥38,700,000、Indirect Cost: ¥11,610,000)
Fiscal Year 2011: ¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000)
Fiscal Year 2010: ¥66,950,000 (Direct Cost: ¥51,500,000、Indirect Cost: ¥15,450,000)
|Outline of Final Research Achievements
To search for novel bioactive peptides associated with the control of appetite and fat accumulation, we used the orphan receptor strategy and newly established method to detect cellular impedance change in response to an agonist stimulation, and found some candidates as novel bioactive substances.
By using gene deficient mice of GC-A (natriuretic peptide receptor-A), we demonstrated that natriuretic peptide signal is associated with fat accumulation. Furthermore, we examined the biological and clinical roles of brain natriuretic peptide and ghrelin in the regulation of energy metabolism in human, and found the close association between blood levels of these hormones and indices of obesity. In addition, we showed that BMP-3b is secreted from adipocytes and is involved in adipocyte differentiation and fat accumulation.