|Budget Amount *help
¥173,420,000 (Direct Cost: ¥133,400,000、Indirect Cost: ¥40,020,000)
Fiscal Year 2014: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
Fiscal Year 2013: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2012: ¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2011: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2010: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
|Outline of Final Research Achievements
We used drosophila orphan GPCRs to find novel endogenous ligands. We chose the target GPCRs, which are homologous receptors to appetite regulating GPCRs in mammals. Consequently, we succeeded to discover five novel bioactive peptides of three categories: CCHamide-1 and -2, dRYamide-1 and -2, and trissin.
We studied about CCHamide-2 and found that it was highly expressed in the drosophila fat body, which corresponds to the mammalian adipose tissue. Moreover, CCHamide-2 is secreted from the fat body and acts on insulin-like peptide producing cells in the drosophila brain to stimulate secretions of insulin-like peptides.