| Budget Amount *help |
¥93,730,000 (Direct Cost: ¥72,100,000、Indirect Cost: ¥21,630,000)
Fiscal Year 2014: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2013: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2010: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
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| Outline of Final Research Achievements |
Obesity and exaggerated lipid accumulation in organs serve as the pathological basis of various diseases. In this study, we have aimed to identify novel regulatory mechanisms for physiological and pathological lipid accumulation of various organs We have found that the Stra13/SREBP1c transcriptional cascade as well as the mTORC1/S6K1signaling pathway play important role in the regulation of hepatic lipid accumulation and pathogenesis of fatty liver. We also found that impaired function of adipocytes resulted in the development of fatty liver diseases and NASH. Moreover, we have found that novel isoforms of the transcriptional coactivator PGC-1α regulate the accumulation of lipid through the control of the function of brown adipose tissue.
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