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Roles of cell chirality in left-right asymmetric tissue morphogenesis

Planned Research

Project AreaFrom molecules, cells to organs : trans-hierarchical logic for higher-order pattern and structures
Project/Area Number 22127004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University (2012-2014)
Tokyo University of Science (2010-2011)

Principal Investigator

MATSUNO Kenji  大阪大学, 理学(系)研究科(研究院), 教授 (60318227)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Hiroyuki  千葉大学, 大学院理学研究科, 准教授 (00398819)
Co-Investigator(Renkei-kenkyūsha) YAMAKAWA Tomoko  大阪大学, 大学院理学研究科, 助教 (20645402)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥182,780,000 (Direct Cost: ¥140,600,000、Indirect Cost: ¥42,180,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2012: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2011: ¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
Fiscal Year 2010: ¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Keywords細胞キラリティ / 左右非対称性 / I型ミオシン / 上皮細胞 / バーテックスモデル / 組織変形 / ショウジョウバエ / 器官形成 / ミオシンI / 消化管 / MyosinID / 形態形成 / アクチン / 細胞極性 / コンピュータ・シミュレーション / 平面内細胞極性 / ミオシンI / メカノバイオロジー / 生体計測 / バイオメカニクス / 左右非対称性形
Outline of Final Research Achievements

Internal organs of animals often show directional Left-Right (LR) asymmetry. The LR asymmetric structure of the embryonic hindgut is formed through a 90 degree counterclockwise rotation. Before this rotation, hindgut epithelial cells show chirality in their shape. The hindgut rotation is driven by the transition from chiral to achiral cells. In this study, we tried to understand the mechanism how cell chirality drives the hindgut rotation.
We developed a method to measure the mechanical force that drives the hindgut rotation. Based on the measurement using this method, we showed that the hindgut rotation is driven by the active force generated by the hindgut itself. During this rotation, the hindgut cells slides and changes their relative position to the direction that is predicted from the rotation of hindgut tube. Our genetic mosaic analysis showed that cell chirality is formed in individual cells, which reflects their intrinsic chiral property.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (92 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (66 results) (of which Invited: 3 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Class I myosins have overlapping and specialized functions in left-right asymmetric development in Drosophila2015

    • Author(s)
      Okumura T, Sasamura T, Inatomi M, Hozumi S, Nakamura M, Hatori R, Taniguchi K, Nakazawa N, Suzuki E, Maeda R, Yamakawa T, Matsuno K
    • Journal Title

      Genetics

      Volume: 199 Issue: 4 Pages: 1183-1199

    • DOI

      10.1534/genetics.115.174698

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ねじれる‐細胞のキラリティの普遍性と機能2015

    • Author(s)
      羽鳥僚, 松野健治
    • Journal Title

      実験医学

      Volume: 33 Pages: 423-428

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Left–right asymmetry is formed in individual cells by intrinsic cell chirality2014

    • Author(s)
      (4)Hatori, R., Ando, T., Sasamura, T., Nakazawa, N., Nakamura, M., Taniguchi, K., Hozumi, S., Kikuta, J., Ishii, M., Matsuno, K.
    • Journal Title

      Mech. Dev.

      Volume: 133 Pages: 146-162

    • DOI

      10.1016/j.mod.2014.04.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞のキラリティが誘発する組織のねじれ2014

    • Author(s)
      (2)羽鳥僚, 松野健治
    • Journal Title

      日本数理生物学会ニュースレター

      Volume: 73 Pages: 20-21

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Loss- and gain-of-function analyses of <i>vacuolar protein sorting 2</i> in Notch signaling of <i>Drosophila melanogaster</i>2013

    • Author(s)
      Naoki Aoyama, Tomoko Yamakawa, Takeshi Sasamura, Yuka Yoshida, Maki Ohori, Hiroyuki Okubo, Eriko Iida, Nobuo Sasaki, Ryu Ueda, Kenji Matsuno
    • Journal Title

      Genes & Genetic Systems

      Volume: 88 Issue: 1 Pages: 45-57

    • DOI

      10.1266/ggs.88.45

    • NAID

      10031183170

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2013 Annual Research Report
  • [Journal Article] Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling.2013

    • Author(s)
      Takeshi Sasamura, Kenji Matsuno, Mark E. Fortini
    • Journal Title

      PLOS Genetics

      Volume: - Issue: 11 Pages: e1003917-e1003917

    • DOI

      10.1371/journal.pgen.1003917

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 生物のからだはどのように左右非対称になるのか?2013

    • Author(s)
      黒田純平、中村充利、松野健治
    • Journal Title

      生産と技術

      Volume: 61 Pages: 99-102

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant of pebble, encoding a RhoGEF, in Drosophila embryos.2013

    • Author(s)
      Mitsutoshi Nakamura
    • Journal Title

      Mechanisms of Development

      Volume: 130 Pages: 169-180

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel Cre/loxP system for mosaic gene expression in the Drosophila embryo2012

    • Author(s)
      Naotaka Nakazawa, Kiichiro Taniguchi, Takashi Okumura, Reo Maeda, Kenji Matsuno
    • Journal Title

      Developmental Dynamics

      Volume: 241 Issue: 5 Pages: 965-974

    • DOI

      10.1002/dvdy.23784

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosopbila midgut2012

    • Author(s)
      Junpei Kuroda, Mitsutoshi Nakamura, Masashi Yoshida, Haruka Yamamoto, Takaaki Maeda, Kiichiro Taniguchi, Naotaka Nakazawa, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Shunsuke Shimaoka, Tamiko Ito, Hironao Iida, Takashi Okumura, Reo Maeda, Kenji Matsuno
    • Journal Title

      Mechanisms of Development

      Volume: 128 Issue: 11-12 Pages: 625-639

    • DOI

      10.1016/j.mod.2011.12.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila2012

    • Author(s)
      Tomoko Yamakawa, Kenta Yamada, Takeshi Sasamura, Naotaka Nakazawa, Maiko Kanai, Emiko Suzuki, Mark E.Fortini, Kenji Matsuno
    • Journal Title

      Development

      Volume: 139 Issue: 3 Pages: 558-567

    • DOI

      10.1242/dev.073858

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation2012

    • Author(s)
      Kenta Yamada
    • Journal Title

      Genes to Cells

      Volume: 16 Issue: 3 Pages: 261-272

    • DOI

      10.1111/j.1365-2443.2011.01488.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上皮細胞の平面内細胞形状のキラリティによる左右非対称な組織形態形成の新たな機構2012

    • Author(s)
      中澤直高
    • Journal Title

      実験医学

      Volume: 30 Pages: 75-78

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Chirality in Planar cell shape contributes to left-right asymmetric epithelial morphogenesis2011

    • Author(s)
      Kiicniro Tanigucni, Reo Maeda, Tadashi Ando, Takashi Okumura, Naotaka Nakazawa, Ryo Hatori, Mitsutoshi Nakamura, Shunya Hozumi, Hiroo Fujiwara, Kenji Matsuno
    • Journal Title

      Science

      Volume: 333 Issue: 6040 Pages: 339-341

    • DOI

      10.1126/science.1200940

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila carrying Pex3 or Pex16 mutations are models of zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes2011

    • Author(s)
      Minoru Nakayama
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 8 Pages: e22984-e22984

    • DOI

      10.1371/journal.pone.0022984

    • NAID

      120004996597

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞のキラルな形状が上皮組織の左右非対称な形態変化を誘発する2011

    • Author(s)
      前田礼男
    • Journal Title

      細胞工学

      Volume: 30 Pages: 1298-1230

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation.2011

    • Author(s)
      Kenta Yamada
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 261-272

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Introgression of Drosophila simulans Nup160 (nuclear pore protein 160) in Drosophila melanogaster Alone Does Not Cause Inviability but Does Cause Female Sterility.2010

    • Author(s)
      Kyouichi Sawamura
    • Journal Title

      Genetics

      Volume: 186 Pages: 669-678

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two pathways for importing GDP-fucose into the ER lumen function redundantly in the O-fucosylation of Notch in Drosophila.2010

    • Author(s)
      Hiroyuki O.Ishikawa
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 4122-4129

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila.2010

    • Author(s)
      Takashi Okumura
    • Journal Title

      Dev.Biol.

      Volume: 344 Pages: 693-706

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cell chirality induces mechnical force driving the left-rihgt directional rotation of the gut in Drosophila2014

    • Author(s)
      Kenji Matsuno
    • Organizer
      The 62nd NIBB conference Force in development
    • Place of Presentation
      岡崎
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞キラリティ:その上流経路と上皮組織の形態形成における機能2014

    • Author(s)
      羽鳥僚、坪井有寿、足立麻衣、石橋朋樹、松野健治
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞のキラリティによる動物の形態形成2014

    • Author(s)
      Ryo Hatori, Alice Tsuboi, Mai Adachi, Tomoki Ishibashi, Kenji Matsuno
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ショウジョウバエ消化管における左右非対称な形態ゆ引き起こす機械的な力の定量化2014

    • Author(s)
      Mai Adachi, Naotaka Nakazawa, Syuki Sigita, Takeo Matsumoto, Kenji Matsuno
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞のキラリティが消化管を左右非対称にする2014

    • Author(s)
      松野健治
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      ホテル福島グリーンパレス、福島、福島県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Quantitation of mechanical force driving left-right asymmetric morphogenesis of the mebryonic gut2014

    • Author(s)
      Mai Adachi, Naotaka Nakazawa, Reo Maeda, Shukei Sigita, Takeo Matsumoto, Kenji Matsuno
    • Organizer
      55th annual Drosophila research conference
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cell-chirality in the left-right asymmetric morphogenesis2013

    • Author(s)
      Kenji Matsuno
    • Organizer
      The 23rd CDB Meeting Building multicellular systems from cellular cross-talk
    • Place of Presentation
      理化学研究所発生・再生科学総合研究センター(兵庫県)(招待講演)
    • Year and Date
      2013-01-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant pebble, encoding a RhoGEF, in Drosophila embryos.2013

    • Author(s)
      Mitsutoshi Nakamura, Kenjiroo Matsumoto, Yuta Iwamoto, Ryo hatori, Kenji Matsuno
    • Organizer
      54th annula Drosophila research conference
    • Place of Presentation
      Washington, DC, UAS
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant pebble, encoding a RhoGEF, in Drosophila embryos.2013

    • Author(s)
      Mitsutoshi Nakamura, Kenjiroo Matsumoto, Yuta Iwamoto, Ryo hatori, Kenji Matsuno
    • Organizer
      The second Asia-Pacific Drosophila research conference
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant pebble, encoding a RhoGEF, in Drosophila embryos.2013

    • Author(s)
      Mitsutoshi Nakamura, Kenjiroo Matsumoto, Yuta Iwamoto, Ryo hatori, Kenji Matsuno
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      くにびきメッセ、松江、島根県
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエにおける消化管上皮の反時計回りの捻転を引き起こす機械的な力の定量化2013

    • Author(s)
      Mai Adachi, Naotaka Nakazawa, Reo Maeda, Shukei Sigita, Takeo Matsumoto, Kenji Matsuno
    • Organizer
      第46回日本発生生物学会
    • Place of Presentation
      くにびきメッセ、松江、島根県
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantification of mechanical force driving the left-handed twisting of the gut epithelial tube in Drosophila2012

    • Author(s)
      中澤直高
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Control of cell number mediated by a Drosophila RhoGEF, Pebble, is required for left-right asymmetric development of the embryonic hindgut2012

    • Author(s)
      中村充利
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quantification of mechanical force driving the left-handed twisting of the gut epithelial tube in Drosophila2012

    • Author(s)
      Naotaka Nakazawa
    • Organizer
      Japanese Drosophila research conference 10
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Year and Date
      2012-10-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] The control of cell number mediated by a Drosophila RhoGEF, Pebble, is required for left-right asymmetric development of the embryonic hindgut2012

    • Author(s)
      Mitsutoshi Nakamura
    • Organizer
      Japanese Drosophila research conference 10
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Year and Date
      2012-10-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Left-right polarization in the cell-shape of epithelium cells occurs cell autonomously during the left-handed contortion of the Drosophila gut2012

    • Author(s)
      Ryo Hatori
    • Organizer
      Japanese Drosophila research conference 10
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Left-right polarization in the cell-shape of epithelium cells occurs cell autonomously during the left-handed contortion of the Drosophila gut2012

    • Author(s)
      Ryo Hatori
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-05-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Planar cell chirality contributes to left-right asymmetric epithelial morphogenesis in Drosophila2012

    • Author(s)
      Kenji Matsuno
    • Organizer
      Conference Jacques-Monod Emergence and evolution of developmental patterns
    • Place of Presentation
      Roscoff (フランス)(招待講演)
    • Year and Date
      2012-04-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functions of a neurogenic gene, pecanex in Notch signaling2011

    • Author(s)
      Kenji Matsuno
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      アテネ、ギリシャ
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mater effect removed screen to find out new neurogenic genes in Drosophila2011

    • Author(s)
      Kenjiroo Matsumoto
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      アテネ、ギリシャ
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms of left-right asymmetric development in Drosophila : approaches involving genome-wide genetic screens and computer2011

    • Author(s)
      Kenji Matsuno
    • Organizer
      第63回日本細胞生物学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functions of a Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left-Right Asymmetry in the Drosophila Embryonic Hindgut2011

    • Author(s)
      Ryo Hatori
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台北、台湾
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Planar cell chirality contributes to left-right asymmetric epithelial morphogenesis in Drosophila2011

    • Author(s)
      Reo Maeda
    • Organizer
      第44回日本発生生物学会年会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Monosaccharide O-fucose modification of Notch contributes to the folding of the Notch receptor in Drosophila2011

    • Author(s)
      Akira Ishio
    • Organizer
      第44回日本発生生物学会年会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Wnt signal plays an essential role in the left-right asymmetric development of the embryonic gut in Drosophila2011

    • Author(s)
      Junpei Kuroda
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Monosaccharide O-fucose modification of Notch for the folding of the Notch receptor in Drosophila2011

    • Author(s)
      Akira Ishio
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Planar cell chirality contributes to reft-right asymmetric epithelial morphogenesis in Drosophila2011

    • Author(s)
      Reo Maeda
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enzymatic activity-independent functions of O-fucosyltransferase 1 in the folding and trafficking of the Notch receptor in Drosophila2011

    • Author(s)
      Naoki Aoyama
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut2011

    • Author(s)
      Ryo Hatori
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic screens of mutants on the second and third chromosomes to identify genes involved in the left-right asymmetric development of the embryonic gut in Drosophila2011

    • Author(s)
      Mitsutoshi Nakamura
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel method for mosaic gene expression with Cre/loxP system in Drosophila embryos2011

    • Author(s)
      Naotaka Nakazawa
    • Organizer
      52^<nd> Annual Drosophila research conference
    • Place of Presentation
      サンディエゴ、米国
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic Screens of Mutants on the Second and Third Chromosomes to Identify Genes Involved in the Left-Right Asymmetric Development of the Embryonic Gut in Drosophila2011

    • Author(s)
      Mitsutoshi Nakamura
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台北、台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] Function of a Neurogenic Gene, pecanex in Notch Signaling2011

    • Author(s)
      Tomoko Yamakawa
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台北、台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Novel Method for Mosaic Gene Expression with Cre-loxP System in Drosophila Embryos2011

    • Author(s)
      Naotaka Nakazawa
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      台北、台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] Monosaccharide O-fucose modification of Notch receptor is required for Notch signaling in Drosophila2011

    • Author(s)
      Akira Ishio
    • Organizer
      The Notch Meeting V
    • Place of Presentation
      アテネ、ギリシャ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functions of Helix-Loop-Helix Transcription Factor, Extramacrochaetae, in Development of Left Right Asymmetry in the Drosophila Embryonic Hindgut2011

    • Author(s)
      Ryo Hatori
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Function of a neurogenic gene, pecanex in Notch signaling2011

    • Author(s)
      Tomoko Yamakawa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of novel neurogenic genes that are potential components of Notch signaling in Drosophila2011

    • Author(s)
      Kenjiroo Matsumoto
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] ショウジョウバエ神経上皮における平面内細胞極性はsingle-minded遺伝子に依存して形成された正中線細胞によって制御されている2011

    • Author(s)
      伊藤多美子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis2011

    • Author(s)
      Reo Maeda
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] A RhoGEF encoded by pebble is involved in the left-right asymmetric development of the embryonic gut in Drosophila2011

    • Author(s)
      Takeshi Muguruma
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Monosacarride O-fucose modification of Notch contributes to Notch folding in Drosophila2011

    • Author(s)
      Akira Ishio
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enzymatic activity-independent functions of O-fucosyltransferase 1 in the folding and endocytic trafficking of the Notch receptor in Drosophila2010

    • Author(s)
      Tomonori Ayukawa
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Notch deficiency implicated in the pathogenesis of congenital disorders of glycosylation llc2010

    • Author(s)
      Naoki Aoyama
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエ杯消化管の左右非対称形成に関与する第2染色体遺伝子の遺伝的スクリーニングによる網羅的同定2010

    • Author(s)
      尾崎あゆみ
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] A genetic screen to identify genes on the 3^<rd> chromosome involved in the left-right asymmetric development of the embryonic gut in Drosophila2010

    • Author(s)
      Mitsutoshi Nakamura
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut2010

    • Author(s)
      Ryo Hatori
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of mechanical force controlled by Myosin1D during the left-right asymmetric morphogenesis of epithelia in Drosophila2010

    • Author(s)
      Naotaka Nakazawa
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Novel role of Notch monosaccharide O-fucose modification is required for Notch signaling in Drosophila2010

    • Author(s)
      Akira Ishio
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wnt signal plays essential roles in the left-right asymmetric development of the embryonic gut Drosophila2010

    • Author(s)
      Jyupei Kuroda
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] SUMO化たんぱく質をユビキチン化するRNF4のショウジョウバエ初期胚核分裂における機能に関する研究2010

    • Author(s)
      橋本珠子
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒラマキガイを用いた冠輪動物順遺伝学モデルの創出の試み2010

    • Author(s)
      植竹啓介
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diversity in the functions of the negative regulators of EGFR signaling may underlie the evolution of eggshell morphology in genus Drosophila2010

    • Author(s)
      Yota Akiyama
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of a helix-loop-helix transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut2010

    • Author(s)
      Ryo Hatori
    • Organizer
      The 16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
    • Place of Presentation
      奈良
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wnt signal plays essential in the left-right asymmetric development of the embryonic gut in Drosophila2010

    • Author(s)
      Jyunpei Kuroda
    • Organizer
      The 16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
    • Place of Presentation
      奈良
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Function of a neurogenic gene pecanex in Notch signaling.2010

    • Author(s)
      Tomoko Yamakawa
    • Organizer
      第5回 Notch研究会
    • Place of Presentation
      東京理科大学 野田キャンパス セミナーハウス
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Monosaccharide O-fucose modification of Notch is required for Notch signaling in the folding of the Notch receptor in Drosophila2010

    • Author(s)
      Akira Ishio
    • Organizer
      第5回 Notch研究会
    • Place of Presentation
      東京理科大学 野田キャンパス セミナーハウス
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] A genome-wide RNAi screen to identity the genes regulating vesicular trafficking of Notch in Drosophila melanogaster2010

    • Author(s)
      Naoki Aoyama
    • Organizer
      第5回 Notch研究会
    • Place of Presentation
      東京理科大学 野田キャンパス セミナーハウス
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two Enzymatic Activity-Independent Functions of O-Fucosyltransferase 1 Separately Contribute to the Folding and Trafficking of the Notch.2010

    • Author(s)
      Kenji Matsuno
    • Organizer
      THE 28^<th> NAITO CONFERRENCE
    • Place of Presentation
      Shonan Village Center
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Planar cell chirality contributes to the left-right asymmetric morphogen esis of the hindgut epithelium in Drosophila.2010

    • Author(s)
      Kenji Matsuno
    • Organizer
      The molecular and developmental biology of Drosophia
    • Place of Presentation
      CRETE GREECE
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functions of helix loop transcription factor, Extramacrochaetae, in development of left-right asymmetry in the Drosophila embryonic hindgut2010

    • Author(s)
      Ryo Hatori
    • Organizer
      第43回日本発生生物学会年回
    • Place of Presentation
      京都国際会館
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] E3ユビキチンリガーゼNeuralizedは、ショウジョウバエ後腸の左右非対称形成の必須である2010

    • Author(s)
      Akira Ishio
    • Organizer
      第43回日本発生生物学会年回
    • Place of Presentation
      京都国際会館
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Planar cell chirality contributes to the left-right asymmetric morphogenesis of epithelium in Drosophila.2010

    • Author(s)
      Kenji Matsuno
    • Organizer
      2^<nd> joint Meeting of the French and Japanese Societies for Development
    • Place of Presentation
      Institut Pasteur, Paris
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wnt signal plays essential roles in the Left-right asymmetric development of the embryonic gut in Drosophila.2010

    • Author(s)
      Junpei Kuroda
    • Organizer
      第62回 日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] A genetic screen of the Drosophila second chromosome to identify genes involved in the left-right asymmetric development of the embryonic gut.2010

    • Author(s)
      Naotaka Nakazawa
    • Organizer
      51^<st> Annual Drosophila Research Conference
    • Place of Presentation
      WASHINGTON, DC
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] A noncanonical role septate junction proteins in the visceral mesoderm, essential for mesodermal closure in Drosophila.2010

    • Author(s)
      Yasuhiro Kawakatsu
    • Organizer
      51^<st> Annual Drosophila Research Conference
    • Place of Presentation
      WASHINGTON, DC
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Book] 分子生物学辞典2012

    • Author(s)
      前田礼男
    • Total Pages
      2
    • Publisher
      みみづく舎
    • Related Report
      2012 Annual Research Report
  • [Book] 生体の科学2012

    • Author(s)
      中山実
    • Total Pages
      4
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] Notch Signaling in Embryology and Cancer2011

    • Author(s)
      Tomoko Yamakawa
    • Total Pages
      10
    • Publisher
      Landes Bioscience
    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Remarks] 大阪大学大学院 理学研究科 生物科学専攻 細胞生物学・松野研究室

    • URL

      http://www.bio.sci.osaka-u.ac.jp/bio_web/lab_page/matsuno/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] Matsuno Lab

    • URL

      http://www.bio.sci.osaka-u.ac.jp/bio_web/lab_page/matsuno/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.bio.sci.oskak-u.ac.jp/bio_web/lab_page/matsuno/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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