|Budget Amount *help
¥158,600,000 (Direct Cost: ¥122,000,000、Indirect Cost: ¥36,600,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2012: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
Fiscal Year 2011: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2010: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
|Outline of Final Research Achievements
We focused on the neural tube formation and attempted to clarify how individual cells contribute to the 3D tissue remodeling during the important morphogenesis and investigated at the molecular, cellular, tissue-levels, and also considering the involvement of physical forces.
We demonstrated that apical constriction and cell elongation driven by actin dynamics and microtubule's stabilization and bundling are the essential processes for the "folding" of the neural plate of Xenopus laevis. In addition, we also showed that rather rapid migration towards the dorsal midline of deep cells of non-neural ectoderm of both lateral sides that does not normally contributes to the neural plate pulls overlaying superficial layer to generate a force to bring two parallel neural folds and enhance the complete closure of neural tube.