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Elucidation of the molecular basis and therapeutic targets for cancer stem cells through establishing their synthetic niche mimicries

Planned Research

Project AreaDevelopment of Novel Treatment Strategies Targeting Cancer Stem Cells
Project/Area Number 22130008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAGA Tetsuya  東京医科歯科大学, 難治疾患研究所, 教授 (40192629)

Co-Investigator(Renkei-kenkyūsha) KAGAWA Tetsushi  東京医科歯科大学, 難治疾患研究所, 准教授 (50270484)
NOBUHISA Ikuo  東京医科歯科大学, 難治疾患研究所, 准教授 (40332879)
TABU Kouichi  東京医科歯科大学, 難治疾患研究所, 特任助教 (10466469)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥181,480,000 (Direct Cost: ¥139,600,000、Indirect Cost: ¥41,880,000)
Fiscal Year 2014: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
Fiscal Year 2013: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
Fiscal Year 2012: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2011: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Fiscal Year 2010: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Keywords癌 / 癌幹細胞 / グリオーマ / ニッチ / ポリマー / マクロファージ / TAM / 鉄 / 自己複製 / 移植 / 多様性 / 癌幹細胞ニッチ / Side Population / 未分化性制御 / シグナル伝達
Outline of Final Research Achievements

CSCs have been postulated as key drivers of cancer relapse and progression, and are supposed to be maintained under the specialized microenvironment called niche. To explore the niche mimicry for rat C6 glioma side population (SP) cells (recognized as CSCs), nearly 400 types of acrylate- and urethane-based synthetic polymers were examined. We found that urethane-based PU10 polymer exhibited the highest niche activity in supporting C6 CSCs. TOF/MS analysis of PU10-bound proteins identified an iron carrier transferrin (Tf). Iron is stored in tumor infiltrating CD204+ macrophages, whose protumoral activity is potently enhanced by CSC-secreted soluble factors. Supportively, the clinical data of 376 glioma patients obtained from NCI (USA) database revealed that expressions of Tf receptor and CD204 genes are found to be predictive of glioma patients' malignancies. Our findings will help elucidate the complex nature of the CSC niche and provide novel therapeutic targets to eradicate cancers.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (88 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (55 results) (of which Invited: 5 results) Book (8 results) Remarks (10 results)

  • [Journal Article] Sox17-ediated Maintenance of Fetal Intra-ortic Hematopoietic Cell Clusters2014

    • Author(s)
      Nobuhisa. Ikuo., Ozawa. M., Uemura. M., Kishikawa. Y., Azumi. M. Harada K. Takagi M Saito. K., Kanai-Azuma M. Kanai. Y Iwama. A. Tetsuya.
    • Journal Title

      MCB

      Volume: (印刷中) Issue: 11 Pages: 1976-90

    • DOI

      10.1128/mcb.01485-13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sox17 as a candidate regulator of myeloid restricted differentiation potential.2014

    • Author(s)
      Anani M, Nobuhisa I, Osawa M, Iwama A, Harada K, Saito K, Taga T
    • Journal Title

      Dev. Growth Differ.

      Volume: 56 Issue: 6 Pages: 469-479

    • DOI

      10.1111/dgd.12147

    • NAID

      40020174678

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GSK3βシグナル経路による神経前駆細胞の自己複製制御2014

    • Author(s)
      鹿川哲史、備前典久、清水健史、田賀哲也
    • Journal Title

      生化学

      Volume: 86 Pages: 67-81

    • NAID

      40020011086

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A growth-promoting signaling component cyclin D1 in neural stem cells has anti-astrogliogenic function to execute self-renewal.2013

    • Author(s)
      Bizen N
    • Journal Title

      Stem Cells

      Volume: Epub ahead of print] Issue: 6 Pages: 1602-15

    • DOI

      10.1002/stem.1613

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells2013

    • Author(s)
      Kusunoki S
    • Journal Title

      Gynecol Oncol

      Volume: in press Issue: 3 Pages: 153-154

    • DOI

      10.1016/j.ygyno.2013.03.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice2013

    • Author(s)
      Uemura. Mami., Ozawa A. Nagala T. Kurosawa K., Tsurukawa. K., Nobuhisa I., Taka T. Mara. K., Kudo, A., Kawakami. H., Saijoh. Y. Kurohmaru M. Kanai, Azuma. M., Kanai. Yoshiakira.
    • Journal Title

      Development

      Volume: 140 Issue: 3 Pages: 639-648

    • DOI

      10.1242/dev.086702

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene regulation of prominin-1 (CD133) in normal and cancerous tissues.2013

    • Author(s)
      K. Tabu, N. Bizen, T. Taga, and S. Tanaka
    • Journal Title

      Adv.Exp.Med.Biol.

      Volume: 777 Pages: 73-85

    • DOI

      10.1007/978-1-4614-5894-4_5

    • ISBN
      9781461458937, 9781461458944
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD45 low c-Kit high cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region2012

    • Author(s)
      Ikuo Nobuhisa
    • Journal Title

      Experimental Cell Research

      Volume: 318 Issue: 6 Pages: 705-715

    • DOI

      10.1016/j.yexcr.2012.01.017

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LIF (Leukemia Inhibitory Factor)2012

    • Author(s)
      備前典久
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57 Pages: 545-552

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression2011

    • Author(s)
      Shoutarou Yamasaki
    • Journal Title

      Development Growth & Differentiation

      Volume: 53 Issue: 7 Pages: 870-877

    • DOI

      10.1111/j.1440-169x.2011.01293.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アストロサイトの発生・分化2011

    • Author(s)
      鹿川哲史
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 1239-1242

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Involvement of the HIPK family in regulation of eyeball size, lens formation and retinal morphogenesis2010

    • Author(s)
      Inoue T, Kagawa T, Inoue-Mochito M, Isono K, Ohtsu N, Nobuhisa I, Fukushima M, Tanihara H, Taga T
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 3233-3238

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells2010

    • Author(s)
      Yoshinaga Y, Kagawa T, Shimizu T, Inoue T, Takada S, Kuratsu J, Taga T
    • Journal Title

      Cell.Mol.Neurobiol.

      Volume: 30 Pages: 1049-1058

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cells with hematopoietic activity in the mouse placenta reside in side population2010

    • Author(s)
      Ramadan A, Nobuhisa I, Yamasaki S, Nakagata N, Taga T
    • Journal Title

      Genes Cells

      Volume: 15 Pages: 983-994

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt・FGF・Notchシグナル相互作用による神経幹細胞自己複製の制御機構2010

    • Author(s)
      鹿川哲史、田賀哲也
    • Journal Title

      医学のあゆみ

      Volume: 233 Pages: 1031-1036

    • Related Report
      2010 Annual Research Report
  • [Presentation] Sustained expression of Sox17 in AGM-derived hematopoietic stem/progenitor cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors.2014

    • Author(s)
      Maha Anani, Ikuo Nobuhisa, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito, Tetsuya Taga
    • Organizer
      The 43rd Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of the Notch signaling pathway and its downstream genes in hematopoietic progenitor cell-containing cell clusters in the aorta-gonad-mesonephros region.2014

    • Author(s)
      Kiyoka Saito, Ikuo Nobuhisa, Maha Anani, Kaho Harada, Tetsuya Taga
    • Organizer
      The 37th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sustained expression of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors.2014

    • Author(s)
      Ikuo Nobuhisa, Maha Anani, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito, Tetsuya Taga
    • Organizer
      The 37th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Autoschizic cancer cell death and its implications to cancer stem cell niche.2014

    • Author(s)
      Kouichi Tabu, Yasuhiro Kokubu, and Tetsuya Taga
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] C6 glioma stem cell-derived GM-CSF induces CD11chighCD204(+) protumoral macrophages.2014

    • Author(s)
      Yasuhiro Kokubu, Kouichi Tabu, Wenqian Wang, Muhammad Baghdadi, Masahisa Jinushi, and Tetsuya Taga
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Roles of cancer-derived heme in erythropoiesis: implications for erythroid niche for cancer stem cells.2014

    • Author(s)
      Wenqian Wang, Kouichi Tabu, Yuichiro Hagiya, Shun-ichiro Ogura, Tetsuya Taga
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] C6 glioma SP cells promote the development of F4/80(+)CD204(+)CD11chigh tumor-associated macrohages through GM-CSF.2014

    • Author(s)
      Yasuhiro Kokubu, Kouichi Tabu, Nozomi Muramatsu, Wenqian Wang, Muhammad Baghdadi, Masahisa Jinushi, and Tetsuya Taga
    • Organizer
      平成26年度がん若手研究者ワークショップ
    • Place of Presentation
      茅野市
    • Year and Date
      2014-09-03 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工ニッチ構築による幹細胞分化制御ニッチの分子基盤解明へのアプローチ2014

    • Author(s)
      田賀哲也、椨康一、備前典久
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-01 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Understanding of C6 glioma cancer stem cell niche with the use of synthetic polymers.2014

    • Author(s)
      Tetsuya Taga and Kouichi Tabu
    • Organizer
      The 12th Stem Cell Research Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2014-05-30 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] C6 glioma SP and MP cells have different metabolism on the ALA-PpIX-heme pathway: an implication for self-creating cancer stem cell niche.2014

    • Author(s)
      Kouichi Tabu, Wenqian Wang, Yuta Sugiyama, Yuichiro Hagiya, Shun-ichiro Ogura, and Tetsuya Taga
    • Organizer
      The 12th Stem Cell Research Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2014-05-30 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Heterogeneity within CD204(+) tumor-associated macrophages induced by C6 glioma stem cells.2014

    • Author(s)
      Yasuhiro Kokubu, Kouichi Tabu, Nozomi Muramatsu, Yoshitaka Murota, Ryosuke Kimura, and Tetsuya Taga
    • Organizer
      The 12th Stem Cell Research Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2014-05-30 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sox17-transduction imparts fetal hematopoietic cells with the myeloid-restricted differentiation potential.2014

    • Author(s)
      Maha Anani, Ikuo Nobuhisa, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito, and Tetsuya Taga
    • Organizer
      The 12th Stem Cell Research Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2014-05-30 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of C6 glioma cancer stem cell niche by using synthetic polymers for the development of therapeutic strategies.2014

    • Author(s)
      Tetsuya Taga and Kouichi Tabu
    • Organizer
      Seoul National University CRI Cancer Symposium
    • Place of Presentation
      Mokpo, Korea
    • Year and Date
      2014-04-16 – 2014-04-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Understanding of cancer stem cell niche for the development of novel therapeutic strategies2013

    • Author(s)
      Tetsuya Taga, Kouichi Tabu, and Nozomi Muramatsu
    • Organizer
      Seoul National University CRI Cancer Symposium
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Polymer-based identification of niche elements for C6 glioma cancer stem cells2013

    • Author(s)
      Kouichi Tabu, Norihisa Bizen, and Tetsuya Taga
    • Organizer
      The 11th Stem Cell Research Symposium
    • Place of Presentation
      Ito Hall, The University of Tokyo, Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Problems and solutions in the analysis of cancer stem cell metabolism using fluorescence indicators2013

    • Author(s)
      Yoshitaka Murota
    • Organizer
      平成25年度がん若手研究者ワークショップ
    • Place of Presentation
      蓼科グランドホテル滝の湯, 茅野市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Glioma stem cell survival strategy in view of niche involving immune/inflammatory cells2013

    • Author(s)
      Tetsuya Taga
    • Organizer
      11th World Congress on Inflammation
    • Place of Presentation
      Natal, Brazil
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Polymer-based identification of cancer stem cell niche for C6 glioma2013

    • Author(s)
      Kouichi Tabu, Nozomi Muramatsu, and Tetsuya Taga
    • Organizer
      72st Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      PACIFICO Yokohama, Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhanced metabolism of protoporphyrin IX in C6 glioma stem cell2013

    • Author(s)
      Wenqian Wang, Kouichi Tabu, Yuta Sugiyama, Yuichiro Hagiya, Shun-ichiro Ogura, Tetsuya Taga
    • Organizer
      The 36th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe International Convention Center, Kobe
    • Related Report
      2013 Annual Research Report
  • [Presentation] Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of SP-defined cancer stem cell metabolism using fluorescence probes2013

    • Author(s)
      Yoshitaka Murota, Kouichi Tabu, and Tetsuya Taga
    • Organizer
      The 36th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe International Convention Center, Kobe
    • Related Report
      2013 Annual Research Report
  • [Presentation] C6 glioma side population cells induce differentiation of bone marrow-derived monocyte lineage2012

    • Author(s)
      Nozomi Muramatsu
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional heterogeneity within a tumor stem cell population identified by the synthetic polymer niche2012

    • Author(s)
      Kouichi Tabu
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 網羅的メチレーション解析による癌幹細胞形質獲得関連遺伝子の同定2012

    • Author(s)
      稲垣徹訓
    • Organizer
      第11回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      日光市
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮体癌の癌幹細胞形質獲得機構における精巣特異的発現遺伝子dbpC/contrinの関与と癌幹細胞マーカーの同定2012

    • Author(s)
      楠木総司
    • Organizer
      第11回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      日光市
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of bone marrow derived-macrophages stimulated by C6 glioma stem cells2012

    • Author(s)
      Nozomi Muramatsu
    • Organizer
      The 10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-06-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cellular heterogeneity contributes to tumor stem cell maintenance in C6 glioma2012

    • Author(s)
      Kouichi Tabu
    • Organizer
      The 10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-06-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic polymer-based neural stem cell niche identification2012

    • Author(s)
      Norihisa Bizen
    • Organizer
      The 10th Annual Meeting of International Society for Stem Cell Research
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-06-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cellular and synthetic niche for C6 glioma stem cells2012

    • Author(s)
      Kouichi Tabu,
    • Organizer
      The 10th Stem Cell Research Symposium
    • Place of Presentation
      Awaji
    • Year and Date
      2012-05-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Multi-disciplinary approaches towards understanding cancer stem cell (CSC) self-renewal strategies: CSC niches as therapeutic targets2012

    • Author(s)
      Tetsuya Taga
    • Organizer
      Seoul National University CRI Cancer Symposium 2012: Innovative Approaches to Explore Novel Druggable Targets
    • Place of Presentation
      Seoul
    • Year and Date
      2012-05-16
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Maintenance of C6 glioma side population with stemness by the cellular and synthetic niche2011

    • Author(s)
      Kouichi Tabu
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌幹細胞の自己複製戦略2011

    • Author(s)
      田賀哲也
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      千葉市(招待講演)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Control of glioma stem cells by the synthetic polymers2011

    • Author(s)
      Kouichi Tabu
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] The cellular and synthetic niches for C6 glioma stem cells2011

    • Author(s)
      椨康一
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      長野県
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経幹細胞の分化制御シグナル2011

    • Author(s)
      田賀哲也
    • Organizer
      第96回医工学フォーラム
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌幹細胞形質獲得機構におけるdbpC/contrinの関与2011

    • Author(s)
      楠木総司
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江市
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 幹細胞維持機構の考察による癌の生存戦略解明へのアプローチ2011

    • Author(s)
      田賀哲也
    • Organizer
      第316回情報計算化学生物学会研究講演会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-04-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of SoxF family proteins in the maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      The 9^<th> Stem Cell Research Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of cyclin D1 in inhibition of astrocyte differentiation from neural stem/progenitor cells2011

    • Author(s)
      Norihisa Bizen
    • Organizer
      The 9^<th> Stem Cell Research Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Annual Research Report
  • [Presentation] External cues and intrinsic properties regulating neural stem cell fate2011

    • Author(s)
      Tetsuya Taga
    • Organizer
      KEY Forum in Developmental Biology and Regenerative Medicine
    • Place of Presentation
      Kumamoto(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉県
    • Related Report
      2011 Annual Research Report
  • [Presentation] Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by SoxF family proteins2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gene expression and functional analyses of histone demethylase Gasc1 in brain.2010

    • Author(s)
      Yasuhiro Kokubu, Yuhei Yamaguchi, Satoko Hattori, Keizo Takao, Joji Inazawa, Tsuyoshi Miyakawa, Tetsushi Kagawa, Tetsuya Taga.
    • Organizer
      The 33rd Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype.2010

    • Author(s)
      Ikuo Nobuhisa, Yoko Kishikawa, Uemura Mami, Maha Anani, Gomaa Ahmed, Masami Kanai-Azuma, Yoshiaki Kanai, Tetsuya Tag.
    • Organizer
      The 33rd Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent cell cycle progression.2010

    • Author(s)
      Norihisa Bizen, Toshihiro Inoue, Takeshi Shimizu, Tetsushi Kagawa, Tetsuya Taga.
    • Organizer
      The 33rd Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cross-interactions among cell-external cues and cell-intrinsic programs controlling brain development.Symposium on Epigenetic regulation in development and differentiation.2010

    • Author(s)
      Tetsuya Taga.
    • Organizer
      The 33rd Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Potential roles of non-cancer stem cell population on C6 glioma formation2010

    • Author(s)
      椨康一、国分康博、備前典久、信久幾夫、鹿川哲史、田賀哲也
    • Organizer
      平成22年度がん若手研究者ワークショップ
    • Place of Presentation
      長野
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 幹細胞の自己複製戦略の考察による癌細胞制御へのアプローチ2010

    • Author(s)
      椨康一、備前典久、清水健史、鹿川哲史、田賀哲也
    • Organizer
      第19回癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] C6 glioma main population maintains side population.2010

    • Author(s)
      Kouichi Tabu, Yasuhiro Kokubu, Norihisa Bizen, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga
    • Organizer
      The 8^<th> Stem Cell Symposium
    • Place of Presentation
      Hyogo
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cells that have hematopoietic activity in the placenta of mouse embryo reside in the side population.2010

    • Author(s)
      Ahmed Ramadan, Ikuo Nobuhisa, Shoutarou, Yamasaki, Tetsuya Taga.
    • Organizer
      The 8^<th> Stem Cell Symposium
    • Place of Presentation
      Hyogo
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells.2010

    • Author(s)
      Norihisa Bizen, Toshihiro Inoue, Takeshi Shimizu, Tetsushi Kagawa, Tetsuya Taga.
    • Organizer
      The 8^<th> Stem Cell Symposium
    • Place of Presentation
      Hyogo
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cells with hematopoietic activity in the mouse placenta reside in side population.2010

    • Author(s)
      Ahmed Ramadan, Ikuo Nobuhisa, Shoutarou Yamasaki, Naoki Nakagata, Tetsuya Taga.
    • Organizer
      14^<th> International Congress of Immunology 2010.
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype.2010

    • Author(s)
      Ikuo Nobuhisa, Yoko Kishikawa, Shoutarou Yamasaki, Gomaa Ahmed, Tetsuya Taga.
    • Organizer
      14^<th> International Congress of Immunology 2010.
    • Place of Presentation
      Kobe
    • Related Report
      2010 Annual Research Report
  • [Presentation] Main population helps side population in C6 glioma cell line.2010

    • Author(s)
      Kouichi Tabu, Tetsuya Taga.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neural Stem Cell Fate Determination.2010

    • Author(s)
      Tetsuya Taga.
    • Organizer
      International Symposium on Stem Cells, Organogenesis, and Regeneration in Fayoum.
    • Place of Presentation
      Egypt, Fayoum
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular Basis of Neural Stem Cell Self-Renewal.2010

    • Author(s)
      Tetsuya Taga.
    • Organizer
      International Symposium on Stem Cells, Organogenesis, and Regeneration in Fayoum.
    • Place of Presentation
      Egypt, Fayoum
    • Related Report
      2010 Annual Research Report
  • [Book] 脳神経系の再生医学―発生・再生の融合的新展開―2015

    • Author(s)
      備前典久、鹿川哲史、田賀哲也
    • Total Pages
      169
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] カンデル神経科学2014

    • Author(s)
      田賀哲也
    • Total Pages
      1649
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2014 Annual Research Report
  • [Book] 脳神経科学イラストレイテッド 改訂第3版2013

    • Author(s)
      鹿川哲史、田賀哲也
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 脳神経科学イラストレイテッド2013

    • Author(s)
      鹿川哲史
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2012 Annual Research Report
  • [Book] サイトカインのすべて2012

    • Author(s)
      備前典久、田賀哲也
    • Publisher
      科学評論社(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Molecular Targets of CNS Tumors2011

    • Author(s)
      Kouichi Tabu
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Book] Stem Cells and Cancer Stem Cells : Therapeutic Applications in Disease and Injury2011

    • Author(s)
      Kouichi Tabu
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] ものづくり技術からみる再生医療-細胞研究・創薬・治療-2011

    • Author(s)
      田賀哲也
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Remarks] 東京医科歯科大学 難治疾患研究所 幹細胞制御分野

    • URL

      http://www.tmd.ac.jp/mri/scr/greetings/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] Department of Stem Cell Regulation, TMDU

    • URL

      http://www.tmd.ac.jp/mri/scr/english/greetings/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京医科歯科大学 研究情報データベース

    • URL

      http://reins.tmd.ac.jp/html/100007289_ja.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] Tokyo Medical and Dental University Res Info DB

    • URL

      http://reins.tmd.ac.jp/html/100007289_en.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京医科歯科大学 難治疾患研究所 幹細胞制御分野

    • URL

      http://www.tmd.ac.jp/mri/scr/greetings/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] Department of Stem Cell Regulation, MRI, TMDU

    • URL

      http://www.tmd.ac.jp/mri/scr/english/greetings/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/scr/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd-research.jp/special/vol01/student.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd-research.jp/special/vol01/company.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/scr/index.html

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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