| Budget Amount *help |
¥227,890,000 (Direct Cost: ¥175,300,000、Indirect Cost: ¥52,590,000)
Fiscal Year 2014: ¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2013: ¥52,260,000 (Direct Cost: ¥40,200,000、Indirect Cost: ¥12,060,000)
Fiscal Year 2012: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2011: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2010: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
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| Outline of Final Research Achievements |
The gonads, testis and ovary, acquire the sexes under genetic regulation, and then establish endocrine regulation by starting sex steroid production. Thereafter, genetic and endocrine regulation, through their synergistic interaction, result in exhibition of sex differences in the gonads and other many organs. In the present study, based on the hypothesis that the sex-dependent gene expression in the establishment of the sex differences would be regulated by sex-specific chromatin structure via variety of histone modification, we aimed to uncover the molecular bases for establishment of the sex differences. In particular, we focused on the function of Ad4BP essential for gonadal development and the chromatin structure. As the consequence, we succeeded to elucidate the molecular mechanisms for sex-dependent differentiation of Sertoli (nursing cells) and Leydig cells (steroid hormone producing cells), both of which are crucial for testicular functions.
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