| Budget Amount *help |
¥110,760,000 (Direct Cost: ¥85,200,000、Indirect Cost: ¥25,560,000)
Fiscal Year 2014: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2013: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2012: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2011: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2010: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
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| Outline of Final Research Achievements |
During development from the fertilized eggs, sex is first determined by the somatic cells. The somatic sex affects the fate of germ cells to develop into sperm or eggs (germ cell sex). However, nobody knows the mechanism in the germ cells which determines the fate (sperm or eggs). We revealed that medaka germ cell exhibits sexually different character before somatic sex is determined. Furthermore on the first time in vertebrates, we successfully identified the gene responsible for the fate decision in medaka germ cells. In the absence of the gene function, medaka develop the ovary ull of functional sperm, indicating that repression of initiation of the spermatogenesis is an essential component of the mechanism that determines the sex in germ cells.We also obtained the evidence that epigenetic regulation is important for proper manifestation of sex and that the sex is affected by an environmental factor(s) like nutrient restriction.
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