|Budget Amount *help
¥59,410,000 (Direct Cost: ¥45,700,000、Indirect Cost: ¥13,710,000)
Fiscal Year 2014: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2013: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2012: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
|Outline of Final Research Achievements
The endoplasmic reticulum aminopeptidase 1 (ERAP1) is centrally involved in peptide trimming before HLA class I presentation. This study found that ERAP1 polymorphisms are associated with Behcet's disease and that also identified evidence of a gene-gene interaction between HLA-B*51 and ERAP1 in the disease.
This study showed associations between certain HLA-DRB1/HLA-DQB1 alleles and sarcoidosis in a Japanese population. In addition, We found an association between BTNL2, located in close proximity to HLA-DRB1 and HLA-DQB1, and also clarified whether the BTNL2 association is independent of the HLA risk alleles.