| Budget Amount *help |
¥72,670,000 (Direct Cost: ¥55,900,000、Indirect Cost: ¥16,770,000)
Fiscal Year 2014: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2013: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2012: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Outline of Final Research Achievements |
Sympathetic regulation of the heart occurs via adenylyl cyclase that produces cAMP, and is stimulated by catecholamine receptors. Cyclic AMP activates its downstream enzymes and phosphorylates various intracellular molecules while its major target is the L-type calcium channel. This channel increases the influx of calcium into cells and regulate the contractility of cardiac myocytes. Because the influx of calcium changes upon cardiac beating, relationship between adenylyl cyclase activity and calcium channel activity may simultaneously change upon beating. We thereby investigated the relationship between the two system based upon our previous understanding. We also found that there is a mutual regulation between adenylyl cyclase and calcium channel activity which is based upon space and time considerations. This understanding is also useful to predict the occurrence of cardiac arrhythmic events.
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