| Budget Amount *help |
¥58,240,000 (Direct Cost: ¥44,800,000、Indirect Cost: ¥13,440,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Outline of Final Research Achievements |
Cardiac impulse propagation is a multi-level biological phenomenon. High-resolution optical mapping revealed that dynamics of cardiac excitation wave propagation was determined by interactions between electrical activity of cardiomyocytes, intercellular communication and myocardial architecture. In the case of circulating excitation, curvature of the propagating excitation wavefront plays addition roles in impulse propagation. This rotating electrical activity i.e. spiral-wave reentry or rotor, underlies cardiac tachyarrhythmia including fibrillation and tachycardia: e.g. persistent atrial fibrillation is maintained by self-sustained 3-dimensional rotors with I-shaped filaments anchored to the atrial pectinate muscle border. Destabilization of the spiral-wave rotation center facilitated early termination of reentrant arrhythmia through collision with anatomical excitation boundaries.
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