Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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Outline of Final Research Achievements |
Chemical biology of natural products focusing on naturally occurring ionotropic glutamte receptor ligands, acromelic acid A and kaitocephalin was studied. Studies involving total synthesis of these natural products, their analog synthesis, ionotropic glutamate receptor binding assay, and structure analysis of ligand-protein complexes of these natural products bound to ionotropic glutamate receptors were conducted. As a result, the target receptor subtype of kaitocephalin was identified. Moreover, (7S)-kaitocephalin was discovered as a more potent NMDA receptor selective ligand than kaitocephalin.
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