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Development and basic/applied study of low molecular weight compounds with novel biofunctions

Planned Research

Project AreaChemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
Project/Area Number 23102010
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Watanabe Hidenori  東京大学, 農学生命科学研究科, 教授 (00202416)

Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords生物活性 / 天然有機化合物 / 有機合成 / 昆虫摂食阻害活性物質 / 抗マラリア活性 / 抗腫瘍活性 / 生物活性天然有機化合物 / 全合成 / 類縁体 / 構造-活性相関 / 標識体 / 癌細胞転移阻害 / 抗菌活性 / UTKO1 / Anthecularin / Neurymenolide / UTK01 / 癌細胞遊走阻害 / アンテキュラリン / 抗原生動物活性
Outline of Final Research Achievements

Under the support of this fund, many types of compounds such as antitumor, migration-inhibiting, antiinflammatory and anti malarial activities which are related to diseases, and herbicidal or insect-antifeeding compounds for plant protection. Those compounds acts as a "key" which triggers the biological phenomenon and have a potential for elucidate the biochemical mechanism. Some of those compounds and related analogs which was obtained through the synthetic research can be a lead compound for developing new drugs. The results obtained will develop the novel approach to bioscientific research.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (48 results)

All 2016 2015 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (41 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Synthesis of marine oxylipin topsentolide A1 and its stereoisomers, and determination of the absolute configuration of the natural product2015

    • Author(s)
      Ken Ishigami, Munetaka Kobayashi, Motoki Takagi, Kazuo Shin-ya, Hidenori Watanabe
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 44 Pages: 8436-8443

    • DOI

      10.1016/j.tet.2015.09.013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and revision of the relative configuration of glabramycin B2015

    • Author(s)
      Ken Ishigami, Masaoki Yamamoto, Hidenori Watanabe
    • Journal Title

      Tetrahedron Letters

      Volume: 56 Issue: 45 Pages: 6290-6293

    • DOI

      10.1016/j.tetlet.2015.09.149

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of (±)-(Z)-2β-hydroxy-14-hydro-β-santalol employing tandem radical cyclization2015

    • Author(s)
      Ken Ishigami, Shinya Yamada, Hidenori Watanabe
    • Journal Title

      Tetrahedron Letters

      Volume: 56 Issue: 42 Pages: 5816-5819

    • DOI

      10.1016/j.tetlet.2015.09.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Formal Synthesis of Azadirachtin2015

    • Author(s)
      Naoki Mori, Takeshi Kitahara, Kenji Mori, Hidenori Watanabe
    • Journal Title

      Angewandte Chemie

      Volume: 127 Issue: 49 Pages: 5133-15136

    • DOI

      10.1002/ange.201507935

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of an olfactory signal molecule that activates the central regulator of reproduction in goats2014

    • Author(s)
      Murata K., Tamogami S., Itou M., Ohkubo Y., Wakabayashi Y., Watahabe H., Okamura H., Takeuchi Y., Mori Y.
    • Journal Title

      Curr Biol

      Volume: 24 Issue: 6 Pages: 681-686

    • DOI

      10.1016/j.cub.2014.01.073

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of (±)-lysidicin A2012

    • Author(s)
      Yusuke Ogura, Ken Ishigami, Hidenori Watanabe
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 6 Pages: 1723-1728

    • DOI

      10.1016/j.tet.2011.12.062

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration2011

    • Author(s)
      Hiroki Kobayashi, Yusuke Ogura, Masato Sawada, Ryoji Nakayama, Kei Takano, Yusuke Minato, Yasushi Takemoto, Etsu Tashiro, Hidenori Watanabe, Masaya Imoto
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Issue: 45 Pages: 39259-39268

    • DOI

      10.1074/jbc.m111.255489

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dichrocephone類の合成研究2016

    • Author(s)
      小林 宗隆、小西 俊介、渡邉 秀典
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] クラビゲリン類の両鏡像体の合成2016

    • Author(s)
      柿本 望、石神 健、渡邉 秀典
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗マラリア活性を有するMyristicyclin類の合成研究2016

    • Author(s)
      久保 伸一郎、渡邉 秀典
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Glabramycin Bの合成と構造訂正2016

    • Author(s)
      山本 将起、石神 健、渡邉 秀典
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Total Synthesis of Glabramycin B2015

    • Author(s)
      asaoki Yamamoto, Ken Ishigami, Hidenori Watanabe
    • Organizer
      The 13th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Kyoto(リーガロイヤルホテル京都)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Total Synthesis of (+)-Clavigerin B2015

    • Author(s)
      Nozomu Kakimoto, Ken Ishigami, Hidenori Watanabe
    • Organizer
      The 13th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      Kyoto(リーガロイヤルホテル京都)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 昆虫摂食阻害活性を有するClavigerin類の全合成2015

    • Author(s)
      柿本望、渡邉秀典
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Litseaone Aの不斉全合成2015

    • Author(s)
      影治秀晃、渡邉秀典
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ピペリジンアルカロイドMicrogrewiapine Aの合成研究2015

    • Author(s)
      野上恭平、石神健、渡邉秀典
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] アザジラクチンの形式不斉合成2014

    • Author(s)
      森直紀、伊藤大輔、北原武、森謙治、渡邉秀典
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知県立県民文化ホール
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] (+)-4'-deacetyl-griseusin A の合成研究2014

    • Author(s)
      佐古尚裕、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Penifulvin A の両鏡像体の全合成2014

    • Author(s)
      深津裕一、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Litseaone A の合成と構造改訂2014

    • Author(s)
      影治秀晃、石神健、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三員環を有する生物活性物質の合成研究2014

    • Author(s)
      土井悠之介、坂口和彦、石神健、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 立体化学の決定を目的としたGlabramycinB の合成研究2014

    • Author(s)
      山本将起、石神健、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pseudolaric acid B の5-7トランス縮環骨格の構築2014

    • Author(s)
      間瀬千晶、森直紀、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 昆虫摂食阻害物質アザジラクチンの形式不斉合成2014

    • Author(s)
      森直紀、渡邉秀典
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] ケミカルバイオロジーへの有機合成化学からのアプローチ2013

    • Author(s)
      渡邉秀典
    • Organizer
      日本農芸化学会2013年度大会 シンポジウム
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clavigerin B の合成研究 - Claisen転位を用いたビシクロ[3.1.1]ヘプテン骨格の構築2013

    • Author(s)
      柿本望、渡邉秀典
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Plumisclerin Aの合成研究2013

    • Author(s)
      服部弘、石田恭次、渡邉秀典
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] ペニフルビン Aの全合成2013

    • Author(s)
      深津裕一、小佐野雄太、森川幸則、渡邉秀典
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] リアノダン類ジテルペンの合成研究2013

    • Author(s)
      若森晋之介、渡邉秀典
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] O-ビニルヒドロキサム酸構造を有するGAFの全合成研究2013

    • Author(s)
      堀之内妙子、渡邉秀典
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2013-03-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic Study on Ryanodane Diterpenes2013

    • Author(s)
      S. Wakamori, H. Watanabe
    • Organizer
      13th International Conference on the Chemistry of Antibiotics and other bioactive compounds
    • Place of Presentation
      Yamanashi, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthetic Study of Clavigerin B Utilizing Ireland Claisen Rearrangement2013

    • Author(s)
      N. Kakimoto, H. Watanabe
    • Organizer
      13th International Conference on the Chemistry of Antibiotics and other bioactive compounds
    • Place of Presentation
      Yamanashi, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthesis of Exiguamide and Litseaone A2013

    • Author(s)
      H. Watanabe, S. Konishi, H. Kageji
    • Organizer
      The 8th International Conference on Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Formal Asymmetric Synthesis of Azadirachtin2013

    • Author(s)
      N. Mori, H. Watanabe
    • Organizer
      The 8th International Conference on Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 昆虫摂食阻害活性を示す Clavigerin 類の合成研究2013

    • Author(s)
      柿本望,渡邉秀典
    • Organizer
      第57回香料・テルペン及び精油化学に関する討論会
    • Place of Presentation
      埼玉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗菌活性を有する Majusculoic acid の合成研究2013

    • Author(s)
      土井悠之介,坂口和彦,石神健,渡邉秀典
    • Organizer
      第57回香料・テルペン及び精油化学に関する討論会
    • Place of Presentation
      埼玉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗白血病活性を有するLitseaone Aの合成研究2013

    • Author(s)
      影治秀晃,渡邉秀典
    • Organizer
      第57回香料・テルペン及び精油化学に関する討論会
    • Place of Presentation
      埼玉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 殺虫活性を有するリアノダンジテルペンの合成研究2013

    • Author(s)
      若森晋之介,渡邉秀典
    • Organizer
      第57回香料・テルペン及び精油化学に関する討論会
    • Place of Presentation
      埼玉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] (+)-Exiguamide の全合成2013

    • Author(s)
      小西俊介,三谷由樹,田村清家,渡邉秀典
    • Organizer
      第57回香料・テルペン及び精油化学に関する討論会
    • Place of Presentation
      埼玉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Plumisclerin A の四員環架橋構造の構築2013

    • Author(s)
      服部弘,石田恭次,石神健,渡邉秀典
    • Organizer
      第57回香料・テルペン及び精油化学に関する討論会
    • Place of Presentation
      埼玉大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthetic Studies on Structurally Unique Natural Products2012

    • Author(s)
      Hidenori WATANABE, Yuichi FUKATSU and Tetsuji MURASE
    • Organizer
      第7回アジア最先端有機化学国際会議
    • Place of Presentation
      シンガポール南洋工科大学
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 天然物合成の楽しみ・苦しみ・喜び2012

    • Author(s)
      渡邉秀典
    • Organizer
      日本薬学会 第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2012-11-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] GAFの全合成研究2012

    • Author(s)
      堀之内妙子、渡邉秀典
    • Organizer
      第56回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヨトウガの幼虫に対して摂食阻害活性を示すPenifulvin Aの合成研究2012

    • Author(s)
      深津裕一、小佐野雄太、森川幸則、渡邉秀典
    • Organizer
      第56回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] タイワンハッカより見出された新規モノテルペン及びその関連化合物の合成による構造確認2012

    • Author(s)
      小西俊介、渡邉秀典
    • Organizer
      第54回天然有機化合物討論会
    • Place of Presentation
      東京農業大学(東京)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Total Syntheses of Oxacyclic Natural Products2011

    • Author(s)
      Ogura Y., Watanabe H
    • Organizer
      The 1st Junior International Conference on Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      アモイ(中国)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stereoselective Synthesis of Natural Products with Ether Rings2011

    • Author(s)
      Hidenori Watanabe, Yusuke Ogura, Shinnosuke Wakamori
    • Organizer
      The 15^<th> Korea-Japan Organic Chemistry Symposium
    • Place of Presentation
      慶州(韓国)(招待講演)
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] エーテル環の立体制御を軸とした生物活性天然物の合成2011

    • Author(s)
      小倉由資、若森晋之介、石神健、渡邉秀典
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report

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Published: 2011-08-01   Modified: 2019-07-29  

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