| Budget Amount *help |
¥43,290,000 (Direct Cost : ¥33,300,000、Indirect Cost : ¥9,990,000)
Fiscal Year 2015 : ¥9,230,000 (Direct Cost : ¥7,100,000、Indirect Cost : ¥2,130,000)
Fiscal Year 2014 : ¥9,230,000 (Direct Cost : ¥7,100,000、Indirect Cost : ¥2,130,000)
Fiscal Year 2013 : ¥9,750,000 (Direct Cost : ¥7,500,000、Indirect Cost : ¥2,250,000)
Fiscal Year 2012 : ¥9,620,000 (Direct Cost : ¥7,400,000、Indirect Cost : ¥2,220,000)
Fiscal Year 2011 : ¥5,460,000 (Direct Cost : ¥4,200,000、Indirect Cost : ¥1,260,000)
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| Outline of Final Research Achievements |
Tetrodotoxin, a puffer fish toxin, inhibits voltage-gated sodium channel (VSGC), a key protein of neurotransmission, however, dose not show subtype selectivity. Purpose of this research is to find a new subtype selective inhibitor of VGSCs, by synthesizing a dozen analogues of TTX. However, slight modification of TTX decreases the inhibitory activity of VGSC. On the other hand, we found that crambesin B carboxylic acid, a marine natural product, exhibits potent inhibition comparable to TTX for the first time.
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