| Budget Amount *help |
¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Fiscal Year 2015: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Regioselective manipulation of one of the multiple hydroxy groups of polyols such as carbohydrates has been a fundamental challenge in current organic synthesis. We have developed the following conventionally difficult molecular transformations; (1) total Synthesis of natural glycosides via catalytic regioselective acylation of carbohydrates, (2) organocatalytic late-stage functionalization of a natural cardiac glycoside, lanatoside C, (3) chemoselective oxidation by electronically tuned nitroxyl radical catalysts, (4) asymmetric desymmetrization of σ－symmetric linear diols, (5) kinetic resolution of a topologically chiral racemic rotaxane, (6) catalyst-controlled regiodivergent vinylogous aza-Morita-Baylis-Hillman reactions.
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