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Development of intracellularly-acting supermolesules for regulating cellular functions

Planned Research

Project AreaMolecular Science for Nanomedicine
Project/Area Number 23107004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Yui Nobuhiko  東京医科歯科大学, 生体材料工学研究所, 教授 (70182665)

Co-Investigator(Kenkyū-buntansha) KONNO Tomohiro  東京大学, 工学系研究科, 准教授 (80371706)
SEO Ji-Hun  東京医科歯科大学, 生体材料工学研究所, 助教 (20611544)
TAMURA Atsushi  東京医科歯科大学, 生体材料工学研究所, 助教 (80631150)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥96,980,000 (Direct Cost: ¥74,600,000、Indirect Cost: ¥22,380,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2014: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2013: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Keywordsポリロタキサン / シクロデキストリン / siRNA / 酵素 / 成長因子 / 超分子 / ポリイオンコンプレックス / ライソゾーム病 / オートファジー / 動的超分子 / 細胞内分解 / 細胞内取り込み
Outline of Final Research Achievements

For regulating cellular functions, we have studied supramolecular polyrotaxanes as novel biomaterials. One of the characteristics seen in polyrotaxanes is the mobility of cyclic compounds, and they can be freely rotational and sliding if any intermolecular forces with the linear chain and the neighboring cyclic compound are eliminated. In particular, polyrotaxanes consisting of α-CD molecules and a poly(ethylene glycol) (PEG) chain are feasible in the structural components as biomaterials.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (101 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (33 results) (of which Acknowledgement Compliant: 12 results,  Peer Reviewed: 32 results) Presentation (60 results) (of which Int'l Joint Research: 8 results,  Invited: 13 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 細胞内分解性ポリロタキサンによるニーマンピック病C型治療2015

    • Author(s)
      田村篤志, 由井伸彦
    • Journal Title

      化学工業

      Volume: 66 Pages: 925-932

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Cationic polyrotaxanes as a feasible framework for the intracellular delivery and sustainable activity of anionic enzymes: a comparison study with methacrylate-based polycations2015

    • Author(s)
      Atsushi Tamura, Go Ikeda, Kei Nishida, Nobuhiko Yui
    • Journal Title

      Macromolecular Bioscience

      Volume: 15 Issue: 8 Pages: 1134-1145

    • DOI

      10.1002/mabi.201500083

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Supramolecular polyelectrolyte complexes of bone morphogenetic protein-2 with sulfonated polyrotaxanes to induce enhanced osteogenic differentiation2015

    • Author(s)
      Masahiko Terauchi, Go Ikeda, Kei Nishida, Atsushi Tamura, Satoshi Yamaguchi, Kiyoshi Harada, Nobuhiko Yui
    • Journal Title

      Macromolecular Bioscience

      Volume: 15 Issue: 7 Pages: 953-964

    • DOI

      10.1002/mabi.201500032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chain architecture and flexibility of α-cyclodextrin/PEG polyrotaxanes in dilute solutions2015

    • Author(s)
      Shinpei Yamada, Yusuke Sanada, Atsushi Tamura, Nobuhiko Yui, Kazuo Sakurai
    • Journal Title

      Polymer Journal

      Volume: 47 Issue: 6 Pages: 464-467

    • DOI

      10.1038/pj.2015.18

    • NAID

      40020479737

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acid-labile polyrotaxane exerting endolysosomal pH-sensitive supramolecular dissociation for therapeutic applications2015

    • Author(s)
      Kei Nishida, Atsushi Tamura, Nobuhiko Yui
    • Journal Title

      Polymer Chemistry

      Volume: 6 Issue: 21 Pages: 4040-4047

    • DOI

      10.1039/c5py00445d

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] β-Cyclodextrin-threaded biocleavable polyrotaxanes ameliorate impaired autophagic flux in Niemann-Pick type C disease2015

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 290 Issue: 15 Pages: 9442-9454

    • DOI

      10.1074/jbc.m115.636803

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increasing the repeating units of ethylene glycol-based dimethacrylates directed towards reduced oxidative stress and co-stimulatory factors expression in human monocytic cells2015

    • Author(s)
      A. Tamura, I. Fukumoto, N. Yui, M. Matsumura, H. Miura
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 103 Issue: 3 Pages: 1060-1066

    • DOI

      10.1002/jbm.a.35251

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Supramolecular flower micelle formation of polyrotaxane-containing triblock copolymers prepared from macro-chain transfer agent bearing molecular hooks2014

    • Author(s)
      A. Tamura, H. Tanaka, N. Yui.
    • Journal Title

      Polymer Chemistry

      Volume: 5 Issue: 15 Pages: 4511-4520

    • DOI

      10.1039/c4py00379a

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Threaded macromolecules as a versatile platform for biomaterials2014

    • Author(s)
      A. Tamura, N. Yui
    • Journal Title

      Chemical Communications

      Volume: 50 Issue: 88 Pages: 13433-13446

    • DOI

      10.1039/c4cc03709j

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cell membrane-permeable and cytocompatible phospholipid polymer nanoprobes conjugated with molecular beacons2014

    • Author(s)
      X. Lin, T. Konno, K. Ishihara
    • Journal Title

      Biomacromolecules

      Volume: 15 Issue: 1 Pages: 150-157

    • DOI

      10.1021/bm401430k

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quantitating distance-dependent, indirect cell-cell interactions with a multilayered phospholipid polymer hydrogel2014

    • Author(s)
      B. Gao, T. Konno, K. Ishihara
    • Journal Title

      Biomaterials

      Volume: 35 Issue: 7 Pages: 2181-2187

    • DOI

      10.1016/j.biomaterials.2013.11.060

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multilayered phospholipid polymer hydrogels for releasing cell growth factors2014

    • Author(s)
      J. Choi, T. Konno, K. Ishihara
    • Journal Title

      Biomaterials and Biomedical Engineering

      Volume: 1 Issue: 1 Pages: 1-12

    • DOI

      10.12989/bme.2014.1.1.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tailoring the supramolecular structure of aminated polyrotaxanes toward enhanced cellular internalization2014

    • Author(s)
      Nanako Yokoyama, Ji-Hun Seo, Atsushi Tamura, Yoshihiro Sasaki, Nobuhiko Yui
    • Journal Title

      Macromolecular Bioscience

      Volume: 14 Issue: 3 Pages: 359-368

    • DOI

      10.1002/mabi.201300198

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous assembly into pseudopolyrotaxane between cyclodextrins and biodegradable polyphosphoester ionomers2014

    • Author(s)
      Atsushi Tamura, Masahiro Tokunaga, Yasuhiko Iwasaki, Nobuhiko Yui
    • Journal Title

      Macromolecular Chemistry and Physics

      Volume: 215 Issue: 7 Pages: 648-653

    • DOI

      10.1002/macp.201300774

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysosomal-specific cholesterol reduction by biocleavable polyrotaxanes for ameliorating Niemann-Pick type C disease2014

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 4356-4356

    • DOI

      10.1038/srep04356

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells2013

    • Author(s)
      Atsushi Tamura, Go Ikeda, Ji-Hun Seo, Koji Tsuchiya, Hirofumi Yajima, Yoshihiro Sasaki, Kazunari Akiyoshi, Nobuhiko Yui.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2252-2252

    • DOI

      10.1038/srep02252

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A supramolecular endosomal escape approach for enhancing gene silencing of siRNA using acid-degradable cationic polyrotaxanes2013

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 1 Issue: 29 Pages: 3535-3544

    • DOI

      10.1039/c3tb20514b

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitization potential of dental resins: 2-hydroxyethyl methacrylate and its water-soluble oligomers induce immunostimulatory effect2013

    • Author(s)
      Izumi Fukumoto, Atsushi Tamura, Mitsuaki Matsumura, Hiroyuki Miura, Nobuhiko Yui
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e82540-e82540

    • DOI

      10.1371/journal.pone.0082540

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox phospholipid polymer microparticles as doubly functional polymer support for immobilization of enzyme oxidase2013

    • Author(s)
      Xiaojie Lin, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara
    • Journal Title

      Colloids and Surfaces B. Biointerfaces

      Volume: 102 Pages: 857-863

    • DOI

      10.1016/j.colsurfb.2012.09.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple procedure for the preparation of precise spatial multicellular phospholipid polymer hydrogels2013

    • Author(s)
      Botao Gao, Tomohiro Konno, Kazuhiko Ishihara
    • Journal Title

      Colloids and Surfaces B. Biointerfaces

      Volume: 108 Pages: 345-351

    • DOI

      10.1016/j.colsurfb.2013.02.022

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipid polymer hydrogel microsphere modulates the cell cycle profile of encapsulated cells2013

    • Author(s)
      Tatsuo Aikawa, Tomohiro Konno, Kazuhiko Ishihara
    • Journal Title

      Soft Matter

      Volume: 9 Issue: 18 Pages: 4628-4634

    • DOI

      10.1039/c3sm50394a

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of the mechanical microenvironment of phospholipid polymer hydrogels to control cell behavior2013

    • Author(s)
      Haruka Oda, Tomohiro Konno, Kazuhiko Ishihara
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 24 Pages: 5891-5896

    • DOI

      10.1016/j.biomaterials.2013.04.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular internalization and gene silencing of siRNA polyplexes by cytocleavable cationic polyrotaxanes with tailored rigid backbones2013

    • Author(s)
      Atsushi Tamura
    • Journal Title

      Biomaterials

      Volume: 34 Issue: 10 Pages: 2480-2491

    • DOI

      10.1016/j.biomaterials.2012.12.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Stereocomplex Formation of Enantiomeric Polylactides Grafted on a Polyrotaxane Platform2013

    • Author(s)
      K. Nagahama, R. Aoki, T. Saito, T. Ouchi, Y. Ohya, N. Yui
    • Journal Title

      Polym. Chem.

      Volume: 4 Issue: 6 Pages: 1769-1773

    • DOI

      10.1039/c3py21055c

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detachment of cells adhered on the photoreactive phospholipid polymer surface by photoirradiation and their functionality2013

    • Author(s)
      Batzaya Byambaa
    • Journal Title

      Colloids Surf. B. Biointerfaces

      Volume: 103 Pages: 489-495

    • DOI

      10.1016/j.colsurfb.2012.11.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different mechanisms for nanoparticle formation between pDNA and siRNA using Polyrotaxane as the polycation2012

    • Author(s)
      Y.Yamada, M.Hashida, T.Nomura, H.Harashima, Y Yamasaki, K.Kataoka, A.Yamashita, R.Katoono, N.Yui
    • Journal Title

      ChemPhysChem

      Volume: 13(5) Issue: 5 Pages: 1161-1165

    • DOI

      10.1002/cphc.201100800

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes2012

    • Author(s)
      Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
    • Journal Title

      Biomaterials

      Volume: 33 Issue: 15 Pages: 3952-3958

    • DOI

      10.1016/j.biomaterials.2012.01.049

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spherical phospholipid polymer hydrogels for cell encapsulation prepared with a flow-focusing microfluidic channel device2012

    • Author(s)
      Tatsuo Aikawa
    • Journal Title

      10.1021/la2037586

      Volume: 28 Pages: 2145-2150

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative and mechisim-based investigation of post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes with well controlled cationic density2012

    • Author(s)
      Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
    • Journal Title

      Biomaterials

      Volume: 33(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Amyloid Aggregation by Polymers Containing Glycosaminoglycan Sulfonate Side Groups2012

    • Author(s)
      三浦佳子、坂本祥吾、福田知博、由井伸彦
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 69 Issue: 1 Pages: 47-53

    • DOI

      10.1295/koron.69.47

    • NAID

      130004489366

    • ISSN
      0386-2186, 1881-5685
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous preparation of a spherical phospholipid polymer hydrogel for cell encapsulation using a flow-focusing microfluidic channel device2012

    • Author(s)
      T.Aikawa, T.Konno, M.Takai, K.Ishihara
    • Journal Title

      Langmuir

      Volume: 28 Issue: 4 Pages: 2145-2150

    • DOI

      10.1021/la2037586

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of cell proliferation by multilayered phospholipid polymer hydrogel through controlled release of bioactive agent2012

    • Author(s)
      Jiyeon Choi, Tomohiro Konno, Madoka Takai and Kazuhiko Ishihara
    • Journal Title

      Biomaterial

      Volume: 33 Issue: 3 Pages: 954-961

    • DOI

      10.1016/j.biomaterials.2011.10.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of polymeric electron-transfer mediator/enzyme hydrogel multilayer on an Au electrode in a layer-by-layer process2012

    • Author(s)
      Z.Li, I.Konno, M.Takai, K.Ishihara
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 34 Issue: 1 Pages: 191-196

    • DOI

      10.1016/j.bios.2012.01.042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 酸分解性ポリロタキサンの設計とニーマンピック病C型に対する治療効果の評価2016

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第25回インテリジェント材料・システムシンポジウム
    • Place of Presentation
      東京女子医科大学, 東京
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Design of pH-sensitive stimulus-sensitive polyrotaxanes exhibiting the supramolecular dissociation in response to metabolic acidosis2015

    • Author(s)
      Kei Nishida, Atsushi Tamura, Nobuhiko Yui
    • Organizer
      International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Heparin-mimicking supermolecules for enhancing supramolecular polyrotaxane enhances osteoinduction ability of with bone morphogenetic protein-22015

    • Author(s)
      Masahiko Terauchi, Takasuke Inada, Tomoki Kanemaru, Kei Nishida, Atsushi Tamura, Satoshi Yamaguchi, Kiyoshi Harada, Nobuhiko Yui
    • Organizer
      International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cyclodextrin-threaded biocleavable polyrotaxanes for the therapy of lysosomal storage disorders2015

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Organizer
      International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic approach to lysosomal storage disorders based on acid-labile polyrotaxanes2015

    • Author(s)
      Nobuhiko Yui, Atsushi Tamura
    • Organizer
      3rd International Symposium on Nanomedicine Molecular Science
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ニーマンピック病C型モデルマウスに対する酸分解性ポリロタキサンの治療効果の評価2015

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ, 京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] ニーマンピック病C型の代謝表現型に対する分解応答型インターロック高分子の機能評価2015

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学, 仙台
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分解応答型インターロックポリマーによる細胞代謝機能の改善2015

    • Author(s)
      田村篤志
    • Organizer
      新学術領域研究ナノメディシン分子科学 第9回公開シンポジウム 細胞内環境の理解と制御
    • Place of Presentation
      東京大学本郷キャンパス小柴ホール, 東京
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ライソゾーム病治療法への応用を目指したpH応答性ポリロタキサンの設計と機能評価2015

    • Author(s)
      西田慶, 田村篤志, 由井伸彦
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター, 札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 環サイズの異なるシクロデキストリンを包接したポリロタキサンの調製と神経変性疾患由来細胞におけるオートファジー機能の評価2015

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター, 札幌
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Polyrotaxane-based intracellular delivery of cyclodextrins for intractable disease therapies2015

    • Author(s)
      Atsushi Tamura
    • Organizer
      Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium
    • Place of Presentation
      Kumamoto Prefectural Community Center PAREA, Kumamoto, Japan
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biocleavable polyrotaxanes for ameliorating lysosomal cholesterol accumulation and impaired autophagic flux in Niemann-Pick type C disease2015

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Organizer
      The 5th Asian Biomaterials Congress
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Year and Date
      2015-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of acid-labile polyrotaxanes eliciting an endolysosomal pH-specific supramolecular dissociation for therapeutic application2015

    • Author(s)
      Kei Nishida, Atsushi Tamura, Nobuhiko Yui
    • Organizer
      The 5th Asian Biomaterials Congress
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Year and Date
      2015-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhanced bone morphogenetic protein 2-induced osteogenic differentiation by supramolecular polyelectrolyte complexation with sulfonated polyrotaxanes2015

    • Author(s)
      Masahiko Terauchi, Go Ikeda, Kei Nishida, Atsushi Tamura, Satoshi Yamaguchi, Kiyoshi Harada, Nobuhiko Yui
    • Organizer
      The 5th Asian Biomaterials Congress
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Year and Date
      2015-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 硫酸化ポリロタキサンを用いた骨形成因子複合体の調製と分化誘導能の評価2015

    • Author(s)
      寺内正彦, 田村篤志, 原田清, 由井伸彦
    • Organizer
      第65回日本歯科理工学会学術講演会
    • Place of Presentation
      仙台市情報・産業プラザ, 仙台
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biocleavable cyclodextrin-based polyrotaxanes for the therapy of lysosomal storage disorders2014

    • Author(s)
      A. Tamura, N. Yui
    • Organizer
      The 10th SPSJ International Polymer Conference (IPC 2014)
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内分解性ポリロタキサンによるライソゾーム病由来細胞のオートファジー機能正常化2014

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀 (東京都江戸川区)
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリロタキサンの超分子構造が酵素静電複合体の物理化学的性質と酵素活性に与える影響2014

    • Author(s)
      池田剛, 田村篤志, 由井伸彦
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀 (東京都江戸川区)
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポリロタキサンの動的骨格を活かした細胞機能の調節-新たな治療法を目指してー2014

    • Author(s)
      由井伸彦
    • Organizer
      第15回リング・チューブ超分子研究会シンポジウム
    • Place of Presentation
      東京工業大学大岡山キャンパス (東京都目黒区)
    • Year and Date
      2014-10-27 – 2014-10-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内分解性超分子を基盤とした難治性代謝疾患治療2014

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎大学文教キャンパス (長崎県長崎市)
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 化学組成の異なる分解性ポリロタキサンの調整とニーマンピック病C型細胞からのコレステロール除去作業の評価2014

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第31回 シクロデキストリンシンポジウム
    • Place of Presentation
      島根県民会館 (島根県松江市)
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Designing cytocleavable polyrotaxanes as a vehicle for molecular logistics of biomacromolecular delivery into target cells2014

    • Author(s)
      N. Yui
    • Organizer
      The 6th Forum on New Materials
    • Place of Presentation
      Palazzo dei Congressi (Italy)
    • Year and Date
      2014-06-15 – 2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Significance of supramolecular frames of CD- based polyrotaxanes as biomaterials: extracellular and intracellular approaches2014

    • Author(s)
      N. Yui
    • Organizer
      17th International Cyclodextrin Symposium
    • Place of Presentation
      Saarland University (Germany)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Lysosomal CD release from biocleavable polyrotaxanes directed toward ameliorating lysosomal storage disorders2014

    • Author(s)
      A. Tamura, N. Yui
    • Organizer
      17th International Cyclodextrin Symposium
    • Place of Presentation
      Saarland University (Germany)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optimizing the molecular structure of polyrotaxanes for efficient intracellular delivery2013

    • Author(s)
      Nanako Yokoyama
    • Organizer
      25th European Conference on Biomaterials
    • Place of Presentation
      Madrid
    • Year and Date
      2013-09-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of Supramolecular Structure of Cytocleavable Cationic Polyrotaxanes in Intracellular Uptake and Gene Silencing of siRNA2013

    • Author(s)
      Atsushi Tamura
    • Organizer
      40th Annual Meeting Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii
    • Year and Date
      2013-07-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分解性ポリロタキサンによる酵素デリバリーと細胞内での酵素活性発現2013

    • Author(s)
      田村篤志
    • Organizer
      第29回 日本DDS学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] カチオン性ポリロタキサンの細胞内取り込みにおける超分子骨格の影響2013

    • Author(s)
      横山奈那子
    • Organizer
      第29回 日本DDS学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytoplasmic Small Intefering RNA Delivery using Cytocleavable Polyrotaxanes2013

    • Author(s)
      Nobuhiko Yui
    • Organizer
      7th International Conference on Materials for Advanced Technologies
    • Place of Presentation
      Singapore
    • Year and Date
      2013-06-30
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Enhanced Cytoplasmic Delivery of Small Interfering RNA Using Acid-Degradable Cationic Polyrotaxanes2013

    • Author(s)
      Atsushi Tamura
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      香港
    • Year and Date
      2013-06-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] siRNAの細胞質移行を促進する酸性環境分解型ポリロタキサンの設計2013

    • Author(s)
      田村篤志
    • Organizer
      第62回 高分子学会年次大会
    • Place of Presentation
      京都
    • Year and Date
      2013-05-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子骨格構造が制御されたポリロタキサン含有ABAトリブロック共重合体の合成2013

    • Author(s)
      田中 朝
    • Organizer
      第62回 高分子学会年次大会
    • Place of Presentation
      京都
    • Year and Date
      2013-05-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Supramolecular logistics using cytocleavable polyrotaxanes for modulating cellular functions2013

    • Author(s)
      Nobuhiko Yui
    • Organizer
      The 2nd International Symposium on Nanomedicine Molecular Science
    • Place of Presentation
      Sanjyo Conference Hall, The University of Tokyo, Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Emerging biomaterials functions through supramolecular polyrotaxanes. The 7th World Congress on Biomimetics2013

    • Author(s)
      Nobuhiko Yui, Ji-Hun Seo, Atsushi Tamura
    • Organizer
      The 7th World Congress on Biomimetics, Artificial Muscles and Nano-Bio (BAMN2013)
    • Place of Presentation
      Jeju Island, South Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Supramolecular polyelectrolyte complexes for enhancing the intracellular activity of delivered biomacromolecules2013

    • Author(s)
      Atsushi Tamura
    • Organizer
      5th TMDU International Summer Program 2013 (ISP2013)
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cytoplasmic small intefering RNA delivery using cytocleavable polyrotaxanes.2013

    • Author(s)
      Nobuhiko Yui, Atsushi Tamura
    • Organizer
      The 7th International Conference on Materials for Advanced Technologies (ICMAT2013)
    • Place of Presentation
      Suntec Singapore, Suntec City, Singapore
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optimizing the molecular structure of polyrotaxanes for efficient intracellular delivery.2013

    • Author(s)
      Nanako Yokoyama, Ji-Hun Seo, Atsushi Tamura, Nobuhiko Yui
    • Organizer
      The 25th European Conference on Biomaterials (ESB)
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effect of supramolecular structure of cytocleavable cationic polyrotaxanes in intracellular uptake and gene silencing of siRNA.2013

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Organizer
      The 40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhanced cytoplasmic delivery of small interfering RNA using acid-degradable cationic polyrotaxanes.2013

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Organizer
      The 4th Asian Biomaterials Congress
    • Place of Presentation
      The Hong Kong University of Science and Technology, Hong Kong, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超分子骨格の特性を活かしたバイオマテリアルの創発2013

    • Author(s)
      由井伸彦
    • Organizer
      第8回四大学連合文化講演会
    • Place of Presentation
      一橋講堂, 東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 超分子バイオマテリアルによる生体分子の細胞内送達とイメージング2013

    • Author(s)
      田村篤志
    • Organizer
      新学術領域ナノメディシン分子科学セミナー 高精度分子イメージングで拓く医学新領域
    • Place of Presentation
      東京医科歯科大学, 東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] In vitro試験法による歯科用レジン成分の感作性評価2013

    • Author(s)
      福本いづみ, 田村篤志, 由井伸彦, 松村光明, 三浦宏之
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超分子骨格が細胞-マテリアル間相互作用に与える影響の検討2013

    • Author(s)
      横山奈那子,徐 知勲,田村篤志,由井伸彦
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分解性機能を有するポリロタキサン-酵素複合体の調製と細胞内導入への応用2013

    • Author(s)
      池田 剛, 田村篤志, 由井伸彦
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポリロタキサンを表層に有する自己組織化ナノ粒子の調製と標的指向化の検討2013

    • Author(s)
      田中 朝, 田村篤志, 由井伸彦
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biodegradable supramolecular nanocarriers for enhancing the intracellular activity of delivered biomacromolecules2013

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Organizer
      第35回 日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内特異的にシクロデキストリンを徐放可能な超分子ナノメディシンの設計とライソゾーム病治療への展開2013

    • Author(s)
      田村篤志, 由井伸彦
    • Organizer
      第30回 シクロデキストリンシンポジウム
    • Place of Presentation
      くまもと県民交流会館パレア, 熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内環境特異的に活性化される分解性ポリロタキサン-酵素複合体の設計と機能評価2013

    • Author(s)
      池田 剛, 田村篤志, 土屋好司, 矢島博文, 由井伸彦
    • Organizer
      第42回 医用高分子シンポジウム
    • Place of Presentation
      産業技術総合研究所 臨海副都心センター, 東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分解性ポリロタキサンによる酵素デリバリーと細胞内での酵素活性発現2013

    • Author(s)
      田村篤志, 池田 剛, 由井伸彦
    • Organizer
      第29回 日本DDS学会学術集会
    • Place of Presentation
      京都テルサ, 京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] カチオン性ポリロタキサンの細胞内取り込みにおける超分子骨格の影響2013

    • Author(s)
      横山奈那子, 徐 知勲, 田村篤志, 由井伸彦
    • Organizer
      第29回 日本DDS学会学術集会
    • Place of Presentation
      京都テルサ, 京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 超分子骨格構造が制御されたポリロタキサン含有ABAトリブロック共重合体の合成2013

    • Author(s)
      田中 朝, 田村篤志, 徐 知勲, 由井伸彦
    • Organizer
      第62回 高分子学会年次大会
    • Place of Presentation
      京都国際会館, 京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Acid-degradable polyrotaxanes for promoting endosomal escape of siRNA2013

    • Author(s)
      Atsushi Tamura, Nobuhiko Yui
    • Organizer
      第62回 高分子学会年次大会
    • Place of Presentation
      京都国際会館, 京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞内環境特異的に活性化される分解性ポリロタキサン-酵素複合体の設計と機能評価2013

    • Author(s)
      池田 剛
    • Organizer
      第42回 医用高分子シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Design of functional polyrotaxane-based intracellular imaging probe2012

    • Author(s)
      Nanako Yokoyama
    • Organizer
      The 9th International Polymer Conference
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞内還元環境分解型ポリロタキサン-siRNA複合体の調製と機能評価2012

    • Author(s)
      田村篤志
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 蛍光共鳴エネルギー移動を利用した超分子プローブの設計と機能評価2012

    • Author(s)
      横山奈那子
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化学修飾ポリロタキサンを用いたタンパク質複合体の調製と機能評価2012

    • Author(s)
      池田 剛
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] 環境応答型カチオン性ポリロタキサンを用いたsiRNAデリバリーと超分子骨格構造の影響2012

    • Author(s)
      田村篤志
    • Organizer
      第61回 高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞内イメージングツールの開発を目指した分解性ポリロタキサンの設計と機能評価2012

    • Author(s)
      横山奈那子
    • Organizer
      第61回 高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞内駆動型分子プローブの開発を目指した新規機能性ポリロタキサンの設計2012

    • Author(s)
      横山奈那子
    • Organizer
      第28回 日本DDS学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Book] DDSキャリア作成プロトコル集 第3章 細胞内分解性ポリロタキサンを用いた薬物送達と超分子医薬への応用2015

    • Author(s)
      田村篤志, 由井伸彦
    • Total Pages
      262
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Book] ゲルテクノロジーハンドブック2014

    • Author(s)
      金野智浩
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2014 Annual Research Report
  • [Book] Intracellular Delivery II2014

    • Author(s)
      T. Konno
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 未来医療を支える先端バイオマテリアル2012

    • Author(s)
      由井伸彦
    • Publisher
      エヌティーエス(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/i-mde/www/material/index3.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.labonet.info/yui/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨形成因子安定保持剤、骨形成因子活性化剤、骨形成因子の安定保持方法、及び骨形成因子の活性化方法2014

    • Inventor(s)
      寺内正彦、池田 剛、田村篤志、山口 聰、原田 清、由井伸彦
    • Industrial Property Rights Holder
      寺内正彦、池田 剛、田村篤志、山口 聰、原田 清、由井伸彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-224265
    • Filing Date
      2014-11-04
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリロタキサン、及びライソゾーム病に対する医薬組成物2013

    • Inventor(s)
      田村篤志, 由井伸彦.
    • Industrial Property Rights Holder
      国立大学法人 東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-172994
    • Filing Date
      2013-08-23
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-01   Modified: 2019-07-29  

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