| Project Area | Deciphering sugar chain-based signals regulating integrative neuronal functions |
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| Project/Area Number | 23110003 |
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Jun-ichi 鳥取大学, 地域学部, 教授 (30221401)
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| Co-Investigator(Renkei-kenkyūsha) |
NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578)
MIKAMI Tadahisa 神戸薬科大学, 薬学部, 講師 (20330425)
MIYATA Shinji 名古屋大学, 生命農学研究科, 特任助教 (60533792)
SATO Ban 筑波大学, 生命環境系生物科学分野, 特任助教 (90443126)
HIRAOKA Syuichi 神戸薬科大学, 薬学部, 研究員 (20291156)
KITAZAWA Kazuyuki 神戸薬科大学, 薬学部, 特別契約研究員 (30770333)
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| Research Collaborator |
EIRAKU Hoshiko
YUZUDOU Noriko
SIDA Miharu
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed(Fiscal Year 2015)
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| Budget Amount *help |
¥127,270,000 (Direct Cost : ¥97,900,000、Indirect Cost : ¥29,370,000)
Fiscal Year 2015 : ¥24,050,000 (Direct Cost : ¥18,500,000、Indirect Cost : ¥5,550,000)
Fiscal Year 2014 : ¥24,050,000 (Direct Cost : ¥18,500,000、Indirect Cost : ¥5,550,000)
Fiscal Year 2013 : ¥25,480,000 (Direct Cost : ¥19,600,000、Indirect Cost : ¥5,880,000)
Fiscal Year 2012 : ¥25,090,000 (Direct Cost : ¥19,300,000、Indirect Cost : ¥5,790,000)
Fiscal Year 2011 : ¥28,600,000 (Direct Cost : ¥22,000,000、Indirect Cost : ¥6,600,000)
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| Keywords | プロテオグリカン / コンドロイチン硫酸 / 神経可塑性 / 抑制性神経細胞 / グリコサミノグリカン / 糖鎖受容体 / 糖鎖シグナル / ペリニューロナルネット / アグリカン / 神経細胞移動 / 神経極性形成 / 細胞接着分子 / 神経突起伸長 / 硫酸基転移酵素 / 眼優位性可塑性 / 臨界期 / 視覚野 |
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| Outline of Final Research Achievements |
Chondroitin sulfate (CS), a major component of the brain extracellular matrix, is reported to play a role in controlling critical period plasticity. Digestion of CS chains has shown to restore visual cortical plasticity in adult animals, but the underlying mechanisms remain unknown. CS chain is a linear polysaccharide consisting of repeating disaccharide units that can be substituted with sulfate groups at various positions, thereby producing characteristic sulfation patterns. Thus we hypothesized that sulfation patterns of CS chains regulate the critical period plasticity. Using transgenic mouse model overexpressing chondroitin 6-sulfotransferase-1, we found that a developmental increase in the 4-sulfation/6-sulfation ratio of CS chains leads to the termination of the critical period in the mouse visual cortex. These results suggest that specific sulfation patterns of CS chains regulate the maturation of parvalbumin-expressing interneurons.
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