| Co-Investigator(Renkei-kenkyūsha) |
NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578)
MIKAMI Tadahisa 神戸薬科大学, 薬学部, 講師 (20330425)
MIYATA Shinji 名古屋大学, 生命農学研究科, 特任助教 (60533792)
SATO Ban 筑波大学, 生命環境系生物科学分野, 特任助教 (90443126)
HIRAOKA Syuichi 神戸薬科大学, 薬学部, 研究員 (20291156)
KITAZAWA Kazuyuki 神戸薬科大学, 薬学部, 特別契約研究員 (30770333)
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| Budget Amount *help |
¥127,270,000 (Direct Cost : ¥97,900,000、Indirect Cost : ¥29,370,000)
Fiscal Year 2015 : ¥24,050,000 (Direct Cost : ¥18,500,000、Indirect Cost : ¥5,550,000)
Fiscal Year 2014 : ¥24,050,000 (Direct Cost : ¥18,500,000、Indirect Cost : ¥5,550,000)
Fiscal Year 2013 : ¥25,480,000 (Direct Cost : ¥19,600,000、Indirect Cost : ¥5,880,000)
Fiscal Year 2012 : ¥25,090,000 (Direct Cost : ¥19,300,000、Indirect Cost : ¥5,790,000)
Fiscal Year 2011 : ¥28,600,000 (Direct Cost : ¥22,000,000、Indirect Cost : ¥6,600,000)
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| Outline of Final Research Achievements |
Chondroitin sulfate (CS), a major component of the brain extracellular matrix, is reported to play a role in controlling critical period plasticity. Digestion of CS chains has shown to restore visual cortical plasticity in adult animals, but the underlying mechanisms remain unknown. CS chain is a linear polysaccharide consisting of repeating disaccharide units that can be substituted with sulfate groups at various positions, thereby producing characteristic sulfation patterns. Thus we hypothesized that sulfation patterns of CS chains regulate the critical period plasticity. Using transgenic mouse model overexpressing chondroitin 6-sulfotransferase-1, we found that a developmental increase in the 4-sulfation/6-sulfation ratio of CS chains leads to the termination of the critical period in the mouse visual cortex. These results suggest that specific sulfation patterns of CS chains regulate the maturation of parvalbumin-expressing interneurons.
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