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Regulatory mechanisms of neuronal activity by chondroitin sulfate chains

Planned Research

Project AreaDeciphering sugar chain-based signals regulating integrative neuronal functions
Project/Area Number 23110003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKobe Pharmaceutical University

Principal Investigator

Kitagawa Hiroshi  神戸薬科大学, 薬学部, 教授 (40221915)

Co-Investigator(Kenkyū-buntansha) TAMURA Jun-ichi  鳥取大学, 地域学部, 教授 (30221401)
Co-Investigator(Renkei-kenkyūsha) NADANAKA Satomi  神戸薬科大学, 薬学部, 講師 (60378578)
MIKAMI Tadahisa  神戸薬科大学, 薬学部, 講師 (20330425)
MIYATA Shinji  名古屋大学, 生命農学研究科, 特任助教 (60533792)
SATO Ban  筑波大学, 生命環境系生物科学分野, 特任助教 (90443126)
HIRAOKA Syuichi  神戸薬科大学, 薬学部, 研究員 (20291156)
KITAZAWA Kazuyuki  神戸薬科大学, 薬学部, 特別契約研究員 (30770333)
Research Collaborator EIRAKU Hoshiko  
YUZUDOU Noriko  
SIDA Miharu  
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥127,270,000 (Direct Cost: ¥97,900,000、Indirect Cost: ¥29,370,000)
Fiscal Year 2015: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2014: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2013: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2012: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2011: ¥28,600,000 (Direct Cost: ¥22,000,000、Indirect Cost: ¥6,600,000)
Keywordsプロテオグリカン / コンドロイチン硫酸 / 神経可塑性 / 抑制性神経細胞 / グリコサミノグリカン / 糖鎖受容体 / 糖鎖シグナル / ペリニューロナルネット / アグリカン / 神経細胞移動 / 神経極性形成 / 細胞接着分子 / 神経突起伸長 / 硫酸基転移酵素 / 視覚野 / 眼優位性可塑性 / 臨界期
Outline of Final Research Achievements

Chondroitin sulfate (CS), a major component of the brain extracellular matrix, is reported to play a role in controlling critical period plasticity. Digestion of CS chains has shown to restore visual cortical plasticity in adult animals, but the underlying mechanisms remain unknown. CS chain is a linear polysaccharide consisting of repeating disaccharide units that can be substituted with sulfate groups at various positions, thereby producing characteristic sulfation patterns. Thus we hypothesized that sulfation patterns of CS chains regulate the critical period plasticity. Using transgenic mouse model overexpressing chondroitin 6-sulfotransferase-1, we found that a developmental increase in the 4-sulfation/6-sulfation ratio of CS chains leads to the termination of the critical period in the mouse visual cortex. These results suggest that specific sulfation patterns of CS chains regulate the maturation of parvalbumin-expressing interneurons.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (167 results)

All 2016 2015 2014 2013 2012 2011 Other

All Int'l Joint Research (1 results) Journal Article (37 results) (of which Peer Reviewed: 36 results,  Acknowledgement Compliant: 11 results,  Open Access: 8 results) Presentation (109 results) (of which Int'l Joint Research: 4 results,  Invited: 29 results) Book (12 results) Remarks (5 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] Cambridge University(英国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Surface Plasmon Resonance Assay of Inhibition by Pharmaceuticals for Thyroxine Hormone Binging to Transport Proteins.2016

    • Author(s)
      Kinouchi, H., Matsuyama, K., Kitagawa, H., and Kamimori, H.
    • Journal Title

      Anal. Biochem.

      Volume: 492 Pages: 43-48

    • DOI

      10.1016/j.ab.2015.09.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin 6-sulfation regulates perineuronal net formation by controlling the stability of aggrecan.2016

    • Author(s)
      Miyata, S., and Kitagawa, H.
    • Journal Title

      Neural Plast.

      Volume: 2016 Pages: 1305801-1305801

    • DOI

      10.1155/2016/1305801

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism; association with progression of multiple sclerosis.2016

    • Author(s)
      Saigoh, K., Yoshimura, S., Izumikawa, T., Miyata, S., Tabara, Y., Matsushita, T., Miki, T., Miyamoto, K., Hirano, M., Kitagawa, H., Kita, J., and Kusunoki, S.
    • Journal Title

      Neurosci. Res.

      Volume: 印刷中 Pages: 55-59

    • DOI

      10.1016/j.neures.2016.01.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Requirements of Glycosaminoglycans for Facilitating Amyloid Fibril Formation of Human Serum Amyloid A2016

    • Author(s)
      Takase H., Tanaka M., Yamamoto A., Watanabe S., Takahashi S., Nadanaka S., Kitagawa H., Yamada T., Mukai T.
    • Journal Title

      Amyloid

      Volume: 印刷中 Issue: 2 Pages: 67-75

    • DOI

      10.3109/13506129.2016.1168292

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chondroitin sulfate and neuronal disorders.2016

    • Author(s)
      Miyata, S., and Kitagawa, H.
    • Journal Title

      Front. Biosci.

      Volume: 21 Issue: 7 Pages: 1330-1340

    • DOI

      10.2741/4460

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Amino acid sequence surrounding the chondroitin sulfate attachment site of thrombomodulin regulates chondroitin polymerization.2015

    • Author(s)
      Izumikawa, T., and Kitagawa, H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 460 Issue: 2 Pages: 233-237

    • DOI

      10.1016/j.bbrc.2015.03.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.2015

    • Author(s)
      Yutsudo, N., and Kitagawa, H.
    • Journal Title

      Exp. Neurol.

      Volume: 274 Pages: 126-133

    • DOI

      10.1016/j.expneurol.2015.07.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A sulfated glycosaminoglycan linkage region is a novel type of Human Natural Killer-1 (HNK-1) epitope expressed on aggrecan in perineuronal nets.2015

    • Author(s)
      Yabuno, K., Morise, J., Kizuka, Y., Hashii, N., Kawasaki N., Takahashi, S., Miyata, S., Izumikawa, T., Kitagawa, H., Takematsu, H., and Oka, S.
    • Journal Title

      PLoS ONE,

      Volume: 10 Issue: 12 Pages: e0144560-e0144560

    • DOI

      10.1371/journal.pone.0144560

    • NAID

      120007128471

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TFE3 is a bHLH-ZIP-type transcription factor that regulates the mammalian Golgi stress response.2015

    • Author(s)
      Taniguchi, M., Nadanaka, S., Kitagawa, H., Yoshida, H. et al.
    • Journal Title

      Cell Struct. Funct.

      Volume: 40

    • NAID

      130004703720

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.2015

    • Author(s)
      Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H
    • Journal Title

      J. Biol. Chem.

      Volume: 290(9) Issue: 9 Pages: 5438-5448

    • DOI

      10.1074/jbc.m114.603266

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chondroitin sulfate-E mediates estrogen-induced osteoanabolism.2015

    • Author(s)
      Koike T, Mikami T, Shida M, Habuchi O, Kitagawa H.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 8994-8994

    • DOI

      10.1038/srep08994

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Processing by Convertases Is Required for Glypican-3-induced Inhibition of Hedgehog Signaling.2015

    • Author(s)
      Capurro, M., Shi, W., Izumikawa, T., Kitagawa, H., and Filmus, J.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 12 Pages: 7576-7585

    • DOI

      10.1074/jbc.m114.612705

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulfate.2015

    • Author(s)
      Miyata, S., and Kitagawa, H.
    • Journal Title

      J. Biochem.

      Volume: 157 Issue: 1 Pages: 13-22

    • DOI

      10.1093/jb/mvu067

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase inhibitory activity.2014

    • Author(s)
      Satomi Nadanaka, Eko Purunomo, Naoko Takeda, Jun-ichi Tamura and Hirosi Kitagawa
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Issue: 22 Pages: 15231-15243

    • DOI

      10.1074/jbc.m113.545343

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Binding Properties of Antimicrobial Agents to Lipid Membranes Using Surface Plasmon Resonance.2014

    • Author(s)
      Kinouchi, H., Arimoto, H., Nishiguchi, K., Oka, M., Maki, H., Kitagawa, H., and Kamimori, H.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 37

    • NAID

      130004677547

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.2014

    • Author(s)
      Nadanaka, S., and Kitagawa, H.
    • Journal Title

      Matrix Biol.

      Volume: 35 Pages: 18-24

    • DOI

      10.1016/j.matbio.2013.10.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Using sugar-remodeling to study chondroitin sulfate function.2014

    • Author(s)
      Kitagawa, H.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 37

    • NAID

      130004703905

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chondroitin sulfate is indispensable for pluripotency and differentiation of mouse embryonic stem cells.2014

    • Author(s)
      Izumikawa, T., Sato, B., and Kitagawa, H.
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 3701-3701

    • DOI

      10.1038/srep03701

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans.2014

    • Author(s)
      Koike, T., Izumikawa, T., Sato, B., and Kitagawa, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 10 Pages: 6695-6708

    • DOI

      10.1074/jbc.m113.520536

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding properties of antimicrobial agents to dipeptide terminal of lipid II using surface Plasmon resonance.2014

    • Author(s)
      Kinouchi, H., Arimoto, H., Nishiguchi, K., Oka, M., Maki, H., Kitagawa, H., and Kamimori, H.
    • Journal Title

      Anal. Biochem.

      Volume: 452 Pages: 67-75

    • DOI

      10.1016/j.ab.2014.02.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis.2014

    • Author(s)
      Miyamoto K, Tanaka N, Moriguchi K, Ueno R, Kadomatsu K, Kitagawa H, Kusunoki S.
    • Journal Title

      Glycobiology.

      Volume: 24 Issue: 5 Pages: 469-475

    • DOI

      10.1093/glycob/cwu014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1.2013

    • Author(s)
      Izumikawa T, Saigoh K, Shimizu J, Tsuji S, Kusunoki S, Kitagawa H.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1830 Issue: 10 Pages: 4806-4812

    • DOI

      10.1016/j.bbagen.2013.06.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of EXTL2, a member of EXT family of tumor suppressors, in liver injury and regeneration processes.2013

    • Author(s)
      Nadanaka, S., Kagiyama, S., and Kitagawa, H.
    • Journal Title

      Biochem. J.

      Volume: 454 Issue: 1 Pages: 133-145

    • DOI

      10.1042/bj20130323

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycosaminoglycan Overproduction in the Aorta Increases Aortic Calcification in Murine Chronic Kidney Disease.2013

    • Author(s)
      Purnomo E, Emoto N, Nugrahaningsih DAA, Nakayama K, Yagi K, Heiden S, Nadanaka S, Kitagawa H, Hirata KI.
    • Journal Title

      JAHA

      Volume: 2 Issue: 5

    • DOI

      10.1161/jaha.113.000405

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Michael Addition-Aromatization Reaction of Dienylimines Bearing a Leaving Group and its Application to the Preparation of Thiol Selective Labeling Reagents Capable of Forming Strong Carbon-Sulfur Bonds.2013

    • Author(s)
      Miyoshi, T., Aoki, Y., Uno, Y., Araki, M., Kamatani, T., Fujii, D., Fujita, Y., Takeda, N., Ueda, M., Kitagawa, H., Emoto, N., Mukai, T., Tanaka, M., and Miyata, O.
    • Journal Title

      J. Org. Chem.

      Volume: 78 Pages: 11433-11443

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.2013

    • Author(s)
      Kosei Takeuchi, Nozomu Yoshioka, Susumu Higa Onaga, Yumi Watanabe, et. al.
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 2740-2740

    • DOI

      10.1038/ncomms3740

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis and function of chondroitin sulfate.2013

    • Author(s)
      Mikami T, Kitagawa H
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1830(10) Issue: 10 Pages: 4719-4733

    • DOI

      10.1016/j.bbagen.2013.06.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EXTL2, a member of EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner2013

    • Author(s)
      Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M.and Kitagawa, H.
    • Journal Title

      J. Biol. Chem

      Volume: 288 Issue: 13 Pages: 9321-9333

    • DOI

      10.1074/jbc.m112.416909

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nephrocalcinosis (Enamel Renal Syndrome) caused by autosomal recessive FAM20A mutations2013

    • Author(s)
      Jaureguiberry, G., De la Dure-Molla, M., Parry, D., Quentric, M., Himmerkus, N., Koike. T., et. al.
    • Journal Title

      Nephron Physiology

      Volume: 122 Issue: 1-2 Pages: 1-6

    • DOI

      10.1159/000349989

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies.2012

    • Author(s)
      Mikami T, Koyama S, Yabuta Y, Kitagawa H.
    • Journal Title

      J. Biol. Chem.

      Volume: 287 (46) Issue: 46 Pages: 38531-38542

    • DOI

      10.1074/jbc.m111.336925

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-12012

    • Author(s)
      Izumikawa, T., Koike, T., Kitagawa, H.
    • Journal Title

      Biochemical journal

      Volume: 441 Issue: 2 Pages: 697-705

    • DOI

      10.1042/bj20111472

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides2012

    • Author(s)
      Tamura, J., et al
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 22 Issue: 3 Pages: 1371-1374

    • DOI

      10.1016/j.bmcl.2011.12.054

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent cortical plasticity by upregulation of chondroitin 6-sulfation2012

    • Author(s)
      Miyata, S., et al
    • Journal Title

      Nature Neurosci.

      Volume: 15 Issue: 3 Pages: 414-422

    • DOI

      10.1038/nn.3023

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to n-cadherin and cadherin-11.2012

    • Author(s)
      Koike, T., Izumikawa, T., Tamura, J., Kitagawa, H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 420 Issue: 3 Pages: 523-529

    • DOI

      10.1016/j.bbrc.2012.03.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 6-硫酸化コンドロイチンの過剰発現により大脳皮質の神経可塑性が維持される2012

    • Author(s)
      宮田真路, 他
    • Journal Title

      ライフサイエンス新着論文レビュー

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain onthrombomodulin2011

    • Author(s)
      N. Nakagawa, T. Izumikawa, H. Kitagawa andS. Oka
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 415(1) Issue: 1 Pages: 109-13

    • DOI

      10.1016/j.bbrc.2011.10.023

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin Sulfate Proteoglycans Regulate Experience-Dependent Neuronal Plasticity2011

    • Author(s)
      Miyata, S., et al
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 23 Issue: 133 Pages: 239-247

    • DOI

      10.4052/tigg.23.239

    • NAID

      10030389175

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Distinct roles of highly sulfated chondroitin sulfates in neural polarity formation.2016

    • Author(s)
      Mikami, T., Shida, M., and Kitagawa, H.
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dysregulated GAG Biosynthesis Affects Inhibitory Interneuron Proliferation During Neural Development and Causes Behavioral Disorders.2016

    • Author(s)
      Nadanaka, S., Ikeda, A., Ishino, A., Onoi, K., and Kitagawa, H.
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of receptors for chondroitin sulfate-E-mediated bidirectional axon guidance.2016

    • Author(s)
      Nakamura, M., Tamura, J., Kitagawa, H., Tojima, T., and Kamiguchi, H.
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chondroitin 6-sulfation is relevant to perineuronal net formation and temporal lobe epilepsy.2016

    • Author(s)
      Kitagawa, H.
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] コンドロイチン硫酸鎖の機能解析に基づく疾患糖鎖生物学 -革新的治療薬の開発を目指して-2015

    • Author(s)
      北川 裕之
    • Organizer
      鳥取大学地域学部研究セミナー
    • Place of Presentation
      鳥取
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経細胞の分化過程におけるコンドロイチン硫酸鎖の合成制御機構2015

    • Author(s)
      灘中 里美,山田 英美,中村 侑,谷口 麻衣,吉田 秀郎,北川 裕之
    • Organizer
      BMB2015 第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Neurocan, a brain chondroitin sulfate proteoglycan, regulates neuronal migration and morphogenesis during corticogenesis.2015

    • Author(s)
      宮田 真路, 佐藤ちひろ, 北島 健, 北川 裕之
    • Organizer
      BMB2015 第38回日本分子生物学会年会、第88回日本生化学大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プロテオグリカン糖鎖の改変は免疫性神経疾患の病態を修飾する2015

    • Author(s)
      楠 進,宮本 勝一,上野 莉乃,森口 幸太,門松 健治,北川 裕之
    • Organizer
      糖鎖免疫研究会 Glyco-lmmunology 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-08-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] コンドロイチン硫酸プロテオグリカンの硫酸化は大脳皮質の発生における神経細胞の移動と形態形成を制御する2015

    • Author(s)
      宮田 真路,北川 裕之
    • Organizer
      第38回日本神経科学大会 Neuroscience2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 第38回日本神経科学大会 Neuroscience20152015

    • Author(s)
      湯通堂 紀子,北川 裕之
    • Organizer
      てんかんにおける6硫酸化コンドロイチン硫酸プロテオグリカンの機能
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] てんかんやPNN形成に関わるコンドロイチンの6-硫酸化2015

    • Author(s)
      北川 裕之
    • Organizer
      新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第9回非公開班会議
    • Place of Presentation
      鳥取
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経細胞の分化過程におけるコンドロイチン硫酸の合成制御機構2015

    • Author(s)
      灘中 里美,北川 裕之
    • Organizer
      新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第9回非公開班会議
    • Place of Presentation
      鳥取
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高硫酸化コンドロイチン硫酸受容体による神経細胞の極性形成過程の制御機構の解析2015

    • Author(s)
      志田 美春,三上 雅久,北川 裕之
    • Organizer
      新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第9回非公開班会議
    • Place of Presentation
      鳥取
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヘパラン硫酸の合成異常が神経発生と行動に与える影響についての解析2015

    • Author(s)
      池田 亜弥,石野 敦重,尾ノ井 孝一,中村 侑,灘中 里美,北川 裕之
    • Organizer
      第62回 日本生化学会 近畿支部例会
    • Place of Presentation
      草津
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] コンドロイチン硫酸鎖による初期軟骨分化過程の制御と作用機構の解析2015

    • Author(s)
      志田 美春,三上 雅久,北川 裕之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] エストロゲンによる骨芽細胞分化とコンドロイチン硫酸2015

    • Author(s)
      北川 裕之
    • Organizer
      弘前大学大学院医学研究科糖鎖医化学講座研究報告会
    • Place of Presentation
      弘前
    • Year and Date
      2015-03-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 糖ヌクレオチド輸送体 Slc35d1 は腸管ホメオスタシスに必要である2014

    • Author(s)
      平岡 秀一,古関 明彦,北川 裕之
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sulfation patterns of chondroitin sulfate regulate neural development and plasticity2014

    • Author(s)
      Miyata, S., Komatsu, Y., Yoshimura, Y., Taya, C., and Kitagawa, H.
    • Organizer
      SFG & JSCR 2014 Joint Annual Meeting
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Highly sulfated chondroitin sulfate chains regulate neuronal polarity formation.2014

    • Author(s)
      Mikami, T., Shida, M., and kitagawa, H.
    • Organizer
      SFG & JSCR 2014 Joint Annual Meeting
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Heparan Sulfate Containing Unsubstituted Glucosamine Residues: Biosynthesis and Heparanase Inhibitory Activity2014

    • Author(s)
      Nadanaka, S., Purnomo, E., Takeda, N., Tamura, J., and Kitagawa, H.
    • Organizer
      SFG & JSCR 2014 Joint Annual Meeting
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulation of neuronal development by glycosaminoglycans2014

    • Author(s)
      Kitagawa, H., Miyata, S., Mikami, T., and Nadanaka, S.
    • Organizer
      SFG & JSCR 2014 Joint Annual Meeting
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dysregulated GAG Biosynthesis Affects Inhibitory Interneuron Proliferation During Neural Development and Causes Behavioral Disorders2014

    • Author(s)
      Nadanaka, S., and Kitagawa, H.
    • Organizer
      SFG & JSCR 2014 Joint Annual Meeting-Satellite II: Glycans in Neuroscience
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Highly sulfated chondroitin sulfate chains regulate neuronal polarity formation.2014

    • Author(s)
      Mikami, T., Shida, M., and kitagawa, H.
    • Organizer
      SFG & JSCR 2014 Joint Annual Meeting-Satellite II: Glycans in Neuroscience
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of Vascular Calcification in Animal Model2014

    • Author(s)
      Purnomo, E., Emoto, N., Nugrahaningsih, DAA., Nakayama, K., Yagi, K., Heiden, S., Nadanaka, S., Kitagawa, H., and Hirata, K.
    • Organizer
      39th Biennial World of Congress of the International College of Surgeons.
    • Place of Presentation
      Denpasar
    • Year and Date
      2014-10-20 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] エストロゲンによる骨芽細胞分化におけるコンドロイチン硫酸鎖の役割2014

    • Author(s)
      北川 裕之
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト血清アミロイドAの繊維形成を促進する鍵となるグリコサミノグリカンの構造因子2014

    • Author(s)
      高瀬 ひろか,田中 将史,高橋 早苗,灘中 里美,北川 裕之,向 高弘
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンドロイチン硫酸の発現により制御される軟骨分化過程の解析2014

    • Author(s)
      志田 美春,三上 雅久,北川 裕之
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス卵巣における加齢に伴ったコンドロイチン硫酸鎖の減少2014

    • Author(s)
      清川 杏里沙,佐藤 伴,北川 裕之
    • Organizer
      第64回日本薬学会近畿支部総会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 硫酸化糖鎖の合成異常が抑制性神経細胞の発生に与える影響2014

    • Author(s)
      山田 英美,灘中 里美,北川 裕之
    • Organizer
      第64回日本薬学会近畿支部総会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Roles of sulfated glycosaminoglycan chains in neural development2014

    • Author(s)
      Kitagawa, H.
    • Organizer
      Fourth ECMNET Conference
    • Place of Presentation
      Antalya
    • Year and Date
      2014-09-29 – 2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 糖鎖の機能解析に基づく疾患糖鎖生物学ー革新的治療薬の開発に向けて2014

    • Author(s)
      北川 裕之
    • Organizer
      平成26年度第2回「メディショナルナノテク研究会」
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 第37回日本神経科学大会2014

    • Author(s)
      Kitagawa, H.
    • Organizer
      Roles of glycosaminoglycans in neuronal development
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遊離グリコサミン残基を含むへパラン硫酸 ーその生合成機構とヘパラナーゼ阻害活性ー2014

    • Author(s)
      灘中 里美,Eko Purunomo, 武田 尚子,田村 純一,北川 裕之
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンドロイチン硫酸による神経細胞の移動と極性の制御2014

    • Author(s)
      宮田 真路,北川 裕之
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンドロイチン硫酸はマウスES細胞の分化に必須である2014

    • Author(s)
      佐藤 伴,泉川 友美,北川 裕之
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経突起ガイダンスを担うコンドロイチン硫酸Eの受容機構2014

    • Author(s)
      中村 真男,田村 純一,北川 裕之,戸島 拓郎,上口 裕之
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンドロイチン硫酸の硫酸化構造による神経可塑性と神経細胞の移動の制御2014

    • Author(s)
      北川 裕之
    • Organizer
      新学術領域合同公開シンポジウム「新学術の最前線~プラズマと生物と医療の協奏曲~」
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 表面プラズモン共鳴法を用いた抗菌•抗真菌薬のLipid II 末端ジペプチド及び脂質膜に対する親和性評価に関する研究2014

    • Author(s)
      木内 啓貴,有本 博一,西口 賢三,岡 雅子,巻 秀樹,北川 裕之,上森 浩
    • Organizer
      GE Life Sciences Day 2014
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンドロイチン硫酸による大脳皮質形成と神経可塑性の制御2014

    • Author(s)
      宮田 真路,北川 裕之
    • Organizer
      第66会日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 硫酸化糖鎖の合成異常が抑制性神経細胞の発生と行動に与える影響2014

    • Author(s)
      灘中 里美,北川 裕之
    • Organizer
      新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第7回非公開班会議
    • Place of Presentation
      掛川
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 極性形成過程におけるコンドロイチン硫酸受容体を介した神経突起の伸長制御機構の解析2014

    • Author(s)
      志田 美春,友廣 彩夏,三上 雅久,竹内 恒成,北川 裕之
    • Organizer
      新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第7回非公開班会議
    • Place of Presentation
      掛川
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] A biochemical and histological investigation to clarify the mechanism of OTX2 localization in the mature visual cortex2014

    • Author(s)
      平岡 秀一,宮田 真路, 北川 裕之
    • Organizer
      新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第7回非公開班会議
    • Place of Presentation
      掛川
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンドロイチン硫酸受容体を介した神経細胞の極性形成過程の制御機構の解析2014

    • Author(s)
      志田 美春,友廣 彩夏,三上 雅久,田村 純一,北川 裕之
    • Organizer
      第61回日本生化学会近畿支部例会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of glycosaminoglycan chains in neural development and plasticity.2014

    • Author(s)
      Kitagawa, H.
    • Organizer
      Development, maintenance and physiology of neural circuits
    • Place of Presentation
      Paris
    • Year and Date
      2014-04-29 – 2014-04-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Roles of chondroitin sulfate in neural development and plasticity.2014

    • Author(s)
      Kitagawa, H.
    • Organizer
      International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Highly sulfated chondroitin sulfates regulate neuronal polarity formation.2014

    • Author(s)
      Mikami, T., Shida M., Tomohiro, A, Kitagawa, H.
    • Organizer
      International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Related Report
      2013 Annual Research Report
  • [Presentation] Signaling mechanisms underlying bidirectional axon guidance induced by chondroitin sulfate.2014

    • Author(s)
      Nakamura, M., Tamura, J., Kitagawa, H., Tojima, T., Kamiguchi, H.
    • Organizer
      International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of visual cortical plasticity by chondroitin and keratan sulfate proteoglycans.2014

    • Author(s)
      Komatsu, Y., Miyata, S., Kitagawa, H., Uchimura, Y., Kadomatsu, K.
    • Organizer
      International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Related Report
      2013 Annual Research Report
  • [Presentation] Proteoglycan and experimental autoimmune encephalomyelitis (EAE)2014

    • Author(s)
      Miyamoto, K., Saigoh, K., Kadomatsu, K., Kitagawa, H., Kusunoki, S.
    • Organizer
      International Symposium on Glyco-Neuroscience
    • Place of Presentation
      Awaji
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高硫酸化コンドロイチン硫酸鎖による神経突起の伸長制御機構の解析2014

    • Author(s)
      志田 美春,友廣 彩夏,三上 雅久,田村 純一,北川 裕之
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖鎖リモデリングによるコンドロイチン硫酸の機能解析2013

    • Author(s)
      北川 裕之
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸の構造変化による細胞機能制御2013

    • Author(s)
      北川 裕之
    • Organizer
      生理学研究所セミナー
    • Place of Presentation
      岡崎
    • Year and Date
      2013-03-16
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] グリコサミノグリカン鎖の機能解析に基づく疾患糖鎖生物学2013

    • Author(s)
      北川 裕之
    • Organizer
      研究講演会(生化学工業株式会社、中央研究所)
    • Place of Presentation
      東京
    • Year and Date
      2013-02-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規のグリコサミノグリカン合成調節機構の脳神経系での役割2013

    • Author(s)
      北川 裕之
    • Organizer
      文部科学省 科研費 新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第4回領域会議
    • Place of Presentation
      宮崎
    • Year and Date
      2013-01-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンドロイチン硫酸鎖による神経突起伸長制御とその作用発現機構の解明2013

    • Author(s)
      三上 雅久 他
    • Organizer
      文部科学省 科研費 新学術領域研究「統合的神経機能の制御を標的とした糖鎖の作動原理解明」第4回領域会議
    • Place of Presentation
      宮崎
    • Year and Date
      2013-01-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Roles of chondroitin sulfate in neural development and plasticity2013

    • Author(s)
      Miyata, S., Komatsu, Y., Yoshimura Y., Taya, C., and Kitagawa, H.
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸はOtx2取り込みを促し臨界期を接続的に制御する2013

    • Author(s)
      侯 旭濱,武内 恒成,宮田 真路,吉岡 慧史,北川 裕之,五十嵐 道弘,杉山 清佳
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン硫酸による軸索伸長と誘導の制御機構2013

    • Author(s)
      中村 真男,田村 純一,北川 裕之,戸島 拓郎,上口 裕之
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] EXTL2によるグリコサミノグリカン合成調節機構とその破綻が神経発生に与える影響2013

    • Author(s)
      北川 裕之
    • Organizer
      新学術領域「神経糖鎖生物学」2013年夏の班会議
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン硫酸による神経突起伸長・極性形成制御とその作用発現機構の解析2013

    • Author(s)
      三上 雅久,玉置 祐樹,志田 美春,友廣 彩夏,北川 裕之
    • Organizer
      新学術領域「神経糖鎖生物学」2013年夏の班会議
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン4-硫酸は神経細胞の移動と極性形成に必要である2013

    • Author(s)
      宮田 真路,北川 裕之
    • Organizer
      新学術領域「神経糖鎖生物学」2013年夏の班会議
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] EXTL2によるグリコサミノグリカン合成調節機構とその破綻が神経発生に与える影響2013

    • Author(s)
      灘中 里美,北川 裕之
    • Organizer
      新学術領域「神経糖鎖生物学」2013年夏の班会議
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン硫酸の硫酸化パターンによる眼優位性可塑性の制御2013

    • Author(s)
      宮田 真路,小松 由起夫,吉村 由美子,多屋 長治,北川 裕之
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン硫酸による反発性神経軸索ガイダンスの調節機構2013

    • Author(s)
      中村 真男,田村 純一,北川 裕之,戸島 拓郎,上口 裕之
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Roles of chondroitin sulfate in neural development and plasticity2013

    • Author(s)
      Kitagawa, H.
    • Organizer
      8th International Conference on Proteoglycans
    • Place of Presentation
      Frankfurt
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Signaling mechanism of bidirectional axon guidance induced by chondroitin sulfate-E2013

    • Author(s)
      Nakamura, M., Tamura, J., Kitagawa, H., Tojima, T., Kamiguchi, H.
    • Organizer
      平成25年度包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン硫酸鎖による骨格筋分化・再生過程の制御2013

    • Author(s)
      三上 雅久, 小山 慎司,薮田 ゆみ,北川 裕之
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス胚性幹細胞におけるコンドロイチン硫酸の機能解析2013

    • Author(s)
      佐藤 伴, 泉川 友美,北川 裕之
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経系におけるコンドロイチン硫酸の役割2013

    • Author(s)
      北川 裕之
    • Organizer
      第11回糖鎖科学コンソーシアムシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸鎖による神経細胞の極性形成制御機構の解析2013

    • Author(s)
      友廣 彩夏,志田 美春,三上 雅久,北川 裕之
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] テストバッテリー方式によるコンドロイチン硫酸鎖形成に関わるC6ST-1トランスジェニックマウスの行動解析2013

    • Author(s)
      吉原 亨,北川 裕之,浅野 雅秀
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 発生・分化におけるコンドロイチン硫酸鎖とその受容体を介したシグナル伝達2012

    • Author(s)
      北川 裕之
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 硫酸化糖鎖によるWntシグナルの調節機構2012

    • Author(s)
      灘中 里美 他
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸による神経細胞移動の制御2012

    • Author(s)
      大庭 真美 他
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      西宮
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンドロイチン硫酸の硫酸化パターンによる眼優位性可塑性の制御2012

    • Author(s)
      宮田 真路 他
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸を中心とした糖鎖による神経活動の制御機構2012

    • Author(s)
      北川 裕之
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークシップ(平成24年度)
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸による神経突起伸長の制御機構の解析2012

    • Author(s)
      三上 雅久 他
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークシップ(平成24年度)
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンドロイチン硫酸の硫酸化パターンによる神経可塑性の制御2012

    • Author(s)
      宮田 真路 他
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークシップ(平成24年度)
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] グリコサミノグリカン合成酵素の遺伝子改変マウスにおける表現型解析2012

    • Author(s)
      三浦 会里子 他
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークシップ(平成24年度)
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Perineuronal netに発現するHNK-1糖鎖抗原とそのキャリアータンパク質に関する研究2012

    • Author(s)
      藪野 景子 他
    • Organizer
      包括型脳科学研究推進支援ネットワーク 夏のワークシップ(平成24年度)
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Basal-like型乳がん細胞のコンドロイチン硫酸鎖を介した浸潤メカニズム2012

    • Author(s)
      北川 裕之
    • Organizer
      第4回次世代シグナル伝達医学グローバルCOE研究討論会
    • Place of Presentation
      淡路
    • Year and Date
      2012-07-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンドロイチン硫酸の硫酸化パターンによる神経可塑性の制御2012

    • Author(s)
      宮田 真路 他
    • Organizer
      第59回日本生化学会近畿支部例会
    • Place of Presentation
      京都
    • Year and Date
      2012-05-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] NHK-1STによるコンドロイチン硫酸鎖の付加制御に関する研究2012

    • Author(s)
      中川 直樹 他
    • Organizer
      第13回 関西グライコサイエンスフォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳の柔らかさのはなし2012

    • Author(s)
      北川裕之, 他
    • Organizer
      名古屋大学オープンレクチャー2012
    • Place of Presentation
      名古屋
    • Year and Date
      2012-03-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチン硫酸鎖による骨格筋分化と神経可塑性の制御2012

    • Author(s)
      北川裕之
    • Organizer
      第19回プロテオグリカンフォーラム
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-02-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチン硫酸鎖の神経突起伸長活性の発現機構2012

    • Author(s)
      三上雅久, 他
    • Organizer
      新学術領域「神経糖鎖生物学」第2回領域会議
    • Place of Presentation
      淡路
    • Related Report
      2011 Annual Research Report
  • [Presentation] 6-硫酸化コンドロイチンの過剰発現によって大脳皮質の神経可塑性が維持される2012

    • Author(s)
      宮田真路, 他
    • Organizer
      新学術領域「神経糖鎖生物学」第2回領域会議
    • Place of Presentation
      淡路
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゴルジ体ストレス応答を利用したプロテオグリカンの糖鎖修飾調節機構2012

    • Author(s)
      灘中里美, 他
    • Organizer
      新学術領域「神経糖鎖生物学」第2回領域会議
    • Place of Presentation
      淡路
    • Related Report
      2011 Annual Research Report
  • [Presentation] ビオチンリンカーに結合したコンドロイチン硫酸オリゴ糖の合成と糖-Midkine間の相互作用2012

    • Author(s)
      武田尚子, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチン4-O-硫酸基転移酵素-2は、コンドロイチンN-アセチルガラクトサミン転移酵素-1によるコンドロイチン鎖の本数合成を制御する2012

    • Author(s)
      泉川友美, 他
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒアルロン酸やコンドロイチンなどの糖鎖の機能2011

    • Author(s)
      北川裕之
    • Organizer
      神戸薬科大学同窓会南九州支部生涯研修セミナー
    • Place of Presentation
      宮崎(招待講演)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Sugar code" regulates Wnt signaling and diffusion2011

    • Author(s)
      Kitagawa, H.
    • Organizer
      The 7^<th> International Conference on Proteoglycams
    • Place of Presentation
      Sydney(招待講演)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Sugar code controls Wnt signaling and diffusion2011

    • Author(s)
      Kitagawa, H.
    • Organizer
      Glycobiology Japan-Netherland Joint Seminar 2011
    • Place of Presentation
      Nagoya(招待講演)
    • Year and Date
      2011-10-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチン硫酸による骨格筋分化の制御2011

    • Author(s)
      北川裕之
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sulfation patterns of chondroitin sulfate proteoglycans regulate critical period plasticity in the visual cortex2011

    • Author(s)
      Miyata, S., et al
    • Organizer
      第31回内藤記念コンファレンス
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biosynthetic mechanism of chondroitin sulfate chain elongation2011

    • Author(s)
      Kitagawa, H.
    • Organizer
      Second Joint Austria/Japan Seminar on Comparative and Developmental Glycobiology
    • Place of Presentation
      Vienna(招待講演)
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-22011

    • Author(s)
      Izumikavva, T., et al
    • Organizer
      21st International Symposium on Glycoconjugates
    • Place of Presentation
      Vienna
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチンN-アセチルガラクトサミン転移酵素-1によるコンドロイチン硫酸鎖の本数の制御機構2011

    • Author(s)
      泉川友美, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチン硫酸合成に関する遺伝子改変マウスの神経系発生再生解析2011

    • Author(s)
      武内恒成, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Down-regulation of Chondroitin 4-O-sulfotransferase-1 by Wnt Signaling Triggers Diffusion of Wnt-3a2011

    • Author(s)
      Nadanaka, S., et al
    • Organizer
      The 7^<th> International Conference on Proteoglycans
    • Place of Presentation
      Sydney
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞分化におけるコンドロイチン硫酸鎖の機能2011

    • Author(s)
      小池敏靖, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンドロイチン硫酸による幹細胞分化や神経可塑性の制御

    • Author(s)
      北川 裕之
    • Organizer
      京大再生医学研究所田畑研セミナー
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 糖鎖リモデリングによるコンドロイチン硫酸の機能解析

    • Author(s)
      北川 裕之
    • Organizer
      第64回FCCAセミナー/FCCAグライコサイエンス若手フォーラム2013
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経細胞がコンドロイチン硫酸を読み取る仕組みの解明

    • Author(s)
      中村 真男,田村 純一,北川 裕之,戸島 拓郎,上口 裕之
    • Organizer
      第64回FCCAセミナー/FCCAグライコサイエンス若手フォーラム2013
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンドロイチン硫酸による神経可塑性や神経細胞移動の制御

    • Author(s)
      北川 裕之
    • Organizer
      平成25年度包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経可塑性や神経細胞の移動におけるコンドロイチン硫酸の役割

    • Author(s)
      北川 裕之
    • Organizer
      厚生労働省科学研究費補助金 難治性疾患等克服研究事業(難治性疾患克服研究事業) 神経変性疾患に関する調査研究班 「病態に根ざしたALSの新規治療法開発」分科班 平成25年度ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] コンドロイチン硫酸による神経突起伸長制御に関する糖鎖受容体の解析

    • Author(s)
      志田 美春,三上 雅久,北川 裕之
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京田辺
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高硫酸化コンドロイチン硫酸の神経突起伸長作用を仲介する細胞内シグナル伝達の解析

    • Author(s)
      友廣 彩夏,木村 祐介,三上 雅久,北川 裕之
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京田辺
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロテオグリカン研究の魅力~細胞の分化を制御するコンドロイチン硫酸

    • Author(s)
      北川 裕之
    • Organizer
      H25年度 生理学研究所研究会 「構造の多様性に立脚した糖鎖機能の解明に向けて」
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 糖鎖の新機能開発・応用ハンドブック 創薬・医療から食品開発まで2015

    • Author(s)
      灘中 里美,北川 裕之
    • Total Pages
      678
    • Publisher
      NTS 双文社印刷
    • Related Report
      2015 Annual Research Report
  • [Book] Sulfated Polysaccharides (Gama, M., Nader, H., and de Oliveira Rocha, H., eds)2015

    • Author(s)
      Tomatsu, S., Shimada, T., Patel, P., Mason, R. W., Mikami, T., Kitagawa, H., Montano, A. M., and Orii, T.
    • Total Pages
      317
    • Publisher
      Nova Science Publishers
    • Related Report
      2015 Annual Research Report
  • [Book] Glycoscience: Biology and Medicine (Taniguchi, N., Endo, T., Hart, G.W., Seeberger, P.H., and Wong, C.H., eds)2015

    • Author(s)
      Mikami, T., Kitagawa, H. et al.
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Sugar chains (Taniguchi, N., Suzuki, T., and Ohtsubo, K., eds)2015

    • Author(s)
      Mikami, T., Kitagawa, H. et al.
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] スタンダード薬学シリーズII 4 生物系薬学 I. 生命現象の基礎2015

    • Author(s)
      三上雅久、北川裕之、他
    • Publisher
      東京化学同人
    • Related Report
      2014 Annual Research Report
  • [Book] Handbook of Glycosyltransferases and Related Genes, 2nd Ed (Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., and Angata, T., eds)2014

    • Author(s)
      Kitagawa, H., Nadanaka, S. et al.
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] Handbook of Glycosyltransferases and Related Genes, 2nd Ed (Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., and Angata, T., eds)2014

    • Author(s)
      Nadanaka, S., and Kitagawa, H.
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] グリコサミノグリカングルクロン酸転移酵素-I2011

    • Author(s)
      泉川友美, 他
    • Publisher
      エル・アイ・シー
    • Related Report
      2011 Annual Research Report
  • [Book] 1H-NMR{(2)オリゴ糖}2011

    • Author(s)
      北川裕之
    • Publisher
      廣川書店
    • Related Report
      2011 Annual Research Report
  • [Book] Enzyme assay of GAG glycosyltransferases for chondroitin sulfate2011

    • Author(s)
      Nadanaka., et al
    • Publisher
      GlycoPOD : GlycoScience Protocol Online http://jcggdb.ip/GlycoPOD/
    • Related Report
      2011 Annual Research Report
  • [Book] Enzyme assay of GAG glycosyltransferases for heparan sulfate2011

    • Author(s)
      Nadanaka, S., et al
    • Publisher
      GlycoPOD : GlycoScience Protocol Online http://jcggdb.jp/GlycoPOD/
    • Related Report
      2011 Annual Research Report
  • [Book] Enzyme assay of xylosyltransferase2011

    • Author(s)
      Koike, T., et al
    • Publisher
      GlycoPOD : GlycoScience Protocol Online http://jcggdb.jp/GlycoPOD/
    • Related Report
      2011 Annual Research Report
  • [Remarks] 神戸薬科大学 生化学研究室

    • URL

      http://www.kobepharma-u.ac.jp/~biochem/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report 2012 Annual Research Report
  • [Remarks] 新学術領域「神経糖鎖生物学」

    • URL

      http://shinkei-tosa.net/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report 2012 Annual Research Report
  • [Remarks] 神戸薬科大学 生化学研究室

    • URL

      http://www.kobepharma-u.ac.jp/~biochem/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 新学術領域「神経糖鎖生物学」

    • URL

      http://shinkei-tosa.net/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.kobepharma-u.ac.jp/~biochem/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨密度増加剤及び骨密度増加剤のスクリーニング方法2013

    • Inventor(s)
      北川 裕之,小池 敏靖
    • Industrial Property Rights Holder
      北川 裕之,小池 敏靖
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-031563
    • Filing Date
      2013-02-20
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] ヘパラナ-ゼ阻害剤及びヘパラナ-ゼ阻害剤のスクリーニング方法2013

    • Inventor(s)
      北川 裕之、灘中 里美、田村 純一
    • Industrial Property Rights Holder
      北川 裕之、灘中 里美、国立大学法人鳥取大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-075157
    • Filing Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨格筋再生促進剤2011

    • Inventor(s)
      北川裕之, 三上雅久
    • Industrial Property Rights Holder
      北川裕之, 三上雅久
    • Industrial Property Number
      2011-202470
    • Filing Date
      2011-09-16
    • Related Report
      2011 Annual Research Report

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Published: 2011-08-01   Modified: 2022-02-07  

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