| Budget Amount *help |
¥99,970,000 (Direct Cost: ¥76,900,000、Indirect Cost: ¥23,070,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
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| Outline of Final Research Achievements |
Glutamate is a main excitatory neurotransmitter in central nervous system and its receptor, glutamate receptors, play important roles in many neuronal functions including memory. In particular, AMPA-type glutamate receptor (AMPA-R) plays central roles in not only main excitatory neurotransmission, but also expression of synaptic plasticity. In this project, we will focus on N-glycosylation of AMPA-R, and we aim to elucidate their functions in synaptic transmission and plasticity. We already found that non-glycosylated AMPA-R is preferentially localized in lipid raft on the cell membrane and this localization has altered channel property, missing desensitization. We also revealed that there are raft-positive and -negative synapses in the same neuron, proposing the hypothesis that glycosylation of AMPA―R decides the synaptic localization, resulting in the regulation of synaptic strength in synaptic plasticity.
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