| Budget Amount *help |
¥210,990,000 (Direct Cost: ¥162,300,000、Indirect Cost: ¥48,690,000)
Fiscal Year 2015: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2014: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2013: ¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2012: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
Fiscal Year 2011: ¥51,740,000 (Direct Cost: ¥39,800,000、Indirect Cost: ¥11,940,000)
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| Outline of Final Research Achievements |
In this research project, we aimed to clarify the molecular mechanisms of epithelial tubular formation. Using three dimensionally cultured epithelial cell lines and primary organs, including ureters, lung, and salivary glands, from fetal mice, several model systems for analyzing tubular formation induced by growth factor signaling were generated. We identified several critical regulators in tubular formation downstream of the growth factor signaling, and proposed their cellular functions in epithelial cell morphology, polarity, growth, differentiation and adhesion. Interestingly, they were also overexpressed in various human cancers and associated with prognosis. Therefore, our new approaches prompt us to identify previously unrecognized novel molecular therapeutic targets for cancer.
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