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Molecular basis of metabolic reprogramming by chromatin conversion

Planned Research

Project AreaCrosstalk of transcriptional control and energy pathways by hub metabolites
Project/Area Number 23116009
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University

Principal Investigator

NAKAO MITSUYOSHI  熊本大学, 発生医学研究所, 教授 (00217663)

Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥122,330,000 (Direct Cost: ¥94,100,000、Indirect Cost: ¥28,230,000)
Fiscal Year 2015: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2014: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2013: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2012: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2011: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Keywords代謝調節 / クロマチン / 遺伝子発現 / リジン脱メチル化 / フラビン / 脂肪細胞 / 癌細胞 / 肝癌細胞 / DNAメチル化
Outline of Final Research Achievements

Epigenetic marks such as methylation of DNA and histones are stably maintained or dynamically changed for gene regulation. The epigenetic states may be reprogrammed by environmental stimuli and inherited as the cellular memory. In fact, epigenetic alteration of disease-related genes is implicated in metabolic diseases and cancer. This study showed that the lysine demethylase LSD1, a nuclear enzyme which utilizes the flavin adenosine dinucleotide (FAD) as a cofactor, regulates energy metabolism in mouse adipocytes. Our data suggest that FAD-dependent demethylation by LSD1 suppresses energy expenditure genes under obese condition. Further, we found that overexpressed LSD1 changes the balance of oxidative phosphorylation and glycolysis in cancer cells, and that LSD2, another family member, works for protecting lipotoxicity in hepatic cells. These indicate that the LSD1 family proteins have an essential role in metabolic reprogramming in various cell types.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (81 results)

All 2016 2015 2014 2013 2012 2011 Other

All Int'l Joint Research (4 results) Journal Article (29 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 26 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (27 results) (of which Int'l Joint Research: 2 results,  Invited: 20 results) Book (14 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Leicester大学/Cambridge大学(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Cologne大学(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 国立衛生学研究所(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Ningbo大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer2016

    • Author(s)
      Kosumi K, Baba Y, Sakamoto Y, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H
    • Journal Title

      Int J Cancer

      Volume: 138 Issue: 2 Pages: 428-39

    • DOI

      10.1002/ijc.29714

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ2016

    • Author(s)
      Y. Xi, W. Shen, L. Ma, M. Zhao, J. Zheng, S. Bu, S. Hino, and M. Nakao.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 472 Issue: 4 Pages: 617-623

    • DOI

      10.1016/j.bbrc.2016.03.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.2015

    • Author(s)
      Sakamoto A, Hino S, Nagaoka K, Anan K, Takase R, Matsumori H, Ojima H, Kanai Y, Arita K, Nakao M
    • Journal Title

      Cancer Research

      Volume: 75(7) Issue: 7 Pages: 1445-1456

    • DOI

      10.1158/0008-5472.can-14-1560

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells2015

    • Author(s)
      Nagaoka, K., Hino, S., Sakamoto, A., Anan, K., Takase, R., Umehara, T., Yokoyama, S., Sasaki, Y., Nakao, M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 35 (7) Issue: 7 Pages: 1068-1080

    • DOI

      10.1128/mcb.01404-14

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinoblastoma protein promotes oxidative phosphorylation through up-regulation of glycolytic genes in oncogene-induced senescent cells2015

    • Author(s)
      S. Takebayashi, H. Tanaka, S. Hino, Y. Nakatsu, T. Igata, A. Sakamoto, M. Narita, and M. Nakao.
    • Journal Title

      Aging Cell

      Volume: 14 Issue: 4 Pages: 689-697

    • DOI

      10.1111/acel.12351

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.2015

    • Author(s)
      Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., Sakai, J.
    • Journal Title

      Molecular Cell

      Volume: 60 Issue: 4 Pages: 584-596

    • DOI

      10.1016/j.molcel.2015.10.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014

    • Author(s)
      Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
    • Journal Title

      Nature Commun

      Volume: 5 Issue: 1 Pages: 3634-3634

    • DOI

      10.1038/ncomms4634

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IGF2 DMR0 methylation, loss of imprinting, and patient prognosis inesophageal squamous cell carcinoma2014

    • Author(s)
      A. Murata, Y. Baba, M. Watanabe, H. Shigaki, K. Miyake, T. Ishimoto, M. Iwatsuki, S. Iwagami, N. Yoshida, E. Oki, M. Morita, M. Nakao, and H. Baba.
    • Journal Title

      Ann. Surg. Oncol.

      Volume: 21 Issue: 4 Pages: 1166-1174

    • DOI

      10.1245/s10434-013-3414-7

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells2014

    • Author(s)
      K. Tokunaga, N. Saitoh, I.G. Goldberg, C. Sakamoto, Y. Yasuda, Y. Yoshida, S. Yamanaka, and M. Nakao.
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 6996-6996

    • DOI

      10.1038/srep06996

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor2014

    • Author(s)
      S. Kanda, T. Ohmori, A. Taguchi, K. Kudo, T. Horiuchi, Y. Sato, S. Hino, Y. Suzuki, M. Sander, S. Sugano, M. Nakao, and R. Nishinakamura.
    • Journal Title

      J. Am. Soc. Nephrol.

      Volume: 25 Issue: 11 Pages: 2584-2595

    • DOI

      10.1681/asn.2013080896

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma2014

    • Author(s)
      Y. Baba, M. Watanabe, A. Murata, H. Shigaki, K. Miyake, T. Ishimoto, M. Iwatsuki, S. Iwagami, N. Yoshida, E. Oki, K. Sakamaki, M. Nakao, and H. Baba.
    • Journal Title

      Clin Cancer Res.

      Volume: 20 Issue: 5 Pages: 1114-1124

    • DOI

      10.1158/1078-0432.ccr-13-1645

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sall1 co-operates with Six2 to actively maintain nephron progenitors2014

    • Author(s)
      S. Kanda, T. Ohmori, A. Taguchi, K. Kudo, T. Horiuchi, Y. Sato, S. Hino, Y. Suzuki, M. Sander, S. Sugano, M. Nakao, and R. Nishinakamura.
    • Journal Title

      J. Am. Soc. Nephrol.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolism-epigenome crosstalk in physiology and diseases2013

    • Author(s)
      S. Hino, K. Nagaoka, and M. Nakao.
    • Journal Title

      J. Hum. Genet.

      Volume: 58 Issue: 7 Pages: 410-415

    • DOI

      10.1038/jhg.2013.57

    • NAID

      10031190034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence2013

    • Author(s)
      N. Sasai, N. Saitoh, H. Saitoh, and M. Nakao.
    • Journal Title

      Plos One

      Volume: 87 Issue: 7 Pages: e68478-e68478

    • DOI

      10.1371/journal.pone.0068478

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.2012

    • Author(s)
      Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K, and Nakao M
    • Journal Title

      Nat. Commun

      Volume: 27;3 Issue: 1 Pages: 758-758

    • DOI

      10.1038/ncomms1755

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells2012

    • Author(s)
      Hirosue A.
    • Journal Title

      Aging Cell

      Volume: 11 Issue: 3 Pages: 553-556

    • DOI

      10.1111/j.1474-9726.2012.00809.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher-order chromatin regulation and differential gene expression in human TNF/LT locus in hepatocellular carcinoma cells2012

    • Author(s)
      Watanabe T.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 32 Issue: 8 Pages: 1529-1541

    • DOI

      10.1128/mcb.06478-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells2012

    • Author(s)
      Taura M., et.al.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 32(8) Issue: 8 Pages: 1581-1590

    • DOI

      10.1128/mcb.06454-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of methyl-binding proteins in chromatin organization and epigenome maintenance2012

    • Author(s)
      Fournier A.
    • Journal Title

      Brief Funct. Genomics

      Volume: 11 Issue: 3 Pages: 251-264

    • DOI

      10.1093/bfgp/elr040

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FAD-dependent lysine demethylase LSD1 regulates cellular energy expenditure2012

    • Author(s)
      Hino S.
    • Journal Title

      Nat.Commun.

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher-order chromatin regulation and differential gene expression in human TNF/LT locus in hepatocellular carcinoma cells2012

    • Author(s)
      Watanabe T.
    • Journal Title

      Mol.Cell.Biol.

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP22012

    • Author(s)
      Saitoh N.
    • Journal Title

      Mol.Biol.Cell

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hmgal is differentially expressed and mediates silencing of the Cd4/Cd8 loci in T cell lineages and leukemic cells2012

    • Author(s)
      Xi Y.
    • Journal Title

      Cancer Sci.

      Volume: (印刷中) Issue: 3 Pages: 439-447

    • DOI

      10.1111/j.1349-7006.2011.02159.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rb/E2F1 regulate innate immune receptor Toll-like receptor 3 in epithelial cells2012

    • Author(s)
      Taura M.
    • Journal Title

      Mol.Cell.Biol.

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of methyl-binding proteins in chromatin organization and epigenome maintenance2012

    • Author(s)
      Fournier A.
    • Journal Title

      Brief Funct.Genomics

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRAG protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos-dependent AP-1 activation2011

    • Author(s)
      Nagashima S.
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 33879-33889

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 概論-エピジェネティック遺伝:生命情報のメモリーに迫る、代謝エピジェネティクス2011

    • Author(s)
      中尾光善
    • Journal Title

      実験医学

      Volume: 29 Pages: 2204-2210

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 癌代謝とエピジェネティクス2011

    • Author(s)
      坂元顕久
    • Journal Title

      実験医学

      Volume: 29 Pages: 2231-2235

    • Related Report
      2011 Annual Research Report
  • [Journal Article] エピジェネティクス機構による細胞制御と病態2011

    • Author(s)
      中尾光善
    • Journal Title

      日本体質医学会雑誌

      Volume: 73 Pages: 47-49

    • Related Report
      2011 Annual Research Report
  • [Presentation] FAD依存性ヒストン脱メチル化酵素LSD1による骨格筋代謝制御2015

    • Author(s)
      阿南浩太郎、日野信次朗、坂元顕久、長岡克弥、高瀬隆太、興梠健作、中尾光善
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会
    • Place of Presentation
      ポートアイランド、神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Epigenetic reprogramming in physiology and cancer2015

    • Author(s)
      M. Nakao
    • Organizer
      The 6th Hiroshima Conference and 50th Anniversary Commemoration
    • Place of Presentation
      広島国際会議場、広島市
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 環境エピゲノムによるエネルギー代謝調節と病態2015

    • Author(s)
      中尾光善
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A cluster of non-coding RNAs, Eleanors, activate the ESR1 locus in therapy-resistant breast cancer cells2015

    • Author(s)
      M. Nakao and N. Saitoh
    • Organizer
      The 40th Naito Conference on Epigenetics-From histone code to therapeutic strategy
    • Place of Presentation
      CHÂTERAISÉ Gateaux Kingdom SAPPORO, 札幌市
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エピジェネティクス機構による代謝制御と病態2015

    • Author(s)
      中尾光善、坂元顕久、長岡克弥、日野信次朗
    • Organizer
      第88回日本内分泌学会学術集会
    • Place of Presentation
      ホテルニューオータニ東京、東京
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 癌細胞内代謝の細胞外微小環境への適応におけるヒストン脱メチル化酵素LSD1の役割2014

    • Author(s)
      坂元顕久、日野信次朗、長岡克弥、阿南浩太郎、高瀬隆太、中尾光善
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Histone demethylase LSD1 regulates metabolism in skeletal muscle cells2014

    • Author(s)
      K. Anan, S. Hino, A. Sakamoto, K. Nagaoka, R. Takase, and M. Nakao
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス:現代人の生命のプログラム2014

    • Author(s)
      中尾光善
    • Organizer
      日本老年医学会北陸地方会
    • Place of Presentation
      金沢医科大学、金沢市
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Epigenetic cell regulation in energy metabolism and cancer2014

    • Author(s)
      M. Nakao
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Epigenetic cell regulation in energy metabolism and cancer2014

    • Author(s)
      M. Nakao
    • Organizer
      9th Asian Epigenomics Meeting
    • Place of Presentation
      シンガポール国立大学、シンガポール
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス機構によるエネルギー代謝調節と病態2013

    • Author(s)
      中尾光善
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本、熊本市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 核スペックルと核小体の形成機序と機能2013

    • Author(s)
      斉藤典子、松森はるか、オサマ・アブラダ・モハメド、藤原さおり、中尾光善.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス機構によるエネルギー代謝調節と病態2013

    • Author(s)
      中尾光善
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル、大阪市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス機構によるエネルギー代謝調節と病態2013

    • Author(s)
      中尾光善
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Metabolism-epigenome crosstalk through FAD/LSD1 pathway2013

    • Author(s)
      S. Hino, A. Sakamoto, K. Nagaoka, K. Anan, R. Takase, and M. Nakao.
    • Organizer
      International Symposium on Transcription and Metabolism
    • Place of Presentation
      淡路夢舞台、淡路島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒストン脱メチル化酵素LSD1による癌代謝制御2012

    • Author(s)
      坂元顕久
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市、福岡国際会議場
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞のエネルギー戦略とエピジェネティクス2012

    • Author(s)
      日野信次朗
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市、福岡国際会議場
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス機構によるエネルギー代謝調節と病態2012

    • Author(s)
      中尾光善
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京都、京王プラザホテル
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス機構による細胞制御と病態2012

    • Author(s)
      中尾光善
    • Organizer
      第35回日本基礎老化学会
    • Place of Presentation
      船橋市、東邦大学
    • Year and Date
      2012-07-26
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] エピジェネティクス機構による細胞病態と治療2012

    • Author(s)
      中尾光善
    • Organizer
      第18回日本遺伝子治療学会学術集会
    • Place of Presentation
      熊本市、熊本テルサ
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] クロマチン因子によるエピジェネティックな細胞制御と病態2011

    • Author(s)
      中尾光善
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜パシフィコ(横浜市)(シンポジウム)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪細胞のエネルギー戦略に関わるエピジェネティクス機構2011

    • Author(s)
      日野信次朗
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路夢舞台(淡路島)(シンポジウム)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] エピジェネティクス機構による細胞制御と病態2011

    • Author(s)
      中尾光善
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都市)(シンポジウム)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] エピジェネティクス機構による細胞制御と老化2011

    • Author(s)
      中尾光善
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都国際会館(京都市)(シンポジウム)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] エピジェネティクス機構による細胞制御と病態2011

    • Author(s)
      中尾光善
    • Organizer
      第65回日本栄養・食糧学会大会サラライトシンポジウム
    • Place of Presentation
      お茶の水女子大学(東京都)(シンポジウム)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] エピジェネティクス機構による肝臓の代謝制御と病態2011

    • Author(s)
      中尾光善
    • Organizer
      第84回日本内分泌学会学術集会
    • Place of Presentation
      神戸ポートアイランド(神戸市)(シンポジウム)
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肥満におけるエネルギー代謝のエピジェネティック制御機構2011

    • Author(s)
      日野信次朗
    • Organizer
      第84回日本内分泌学会学術集会
    • Place of Presentation
      神戸ポートアイランド(神戸市)(ミニシンポジウム)
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Book] あなたと私はどうして違う? 体質と遺伝子のサイエンス-99.9%同じ設計図から個性と病気が生じる秘密2015

    • Author(s)
      中尾光善
    • Total Pages
      221
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report
  • [Book] ドライシンドロームの基礎と臨床(分担執筆)2015

    • Author(s)
      中元雅史、森山雅文、石原 宏、中尾光善
    • Total Pages
      201
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 驚異のエピジェネティクス-遺伝子がすべてではない!? 生命のプログラムの秘密2014

    • Author(s)
      中尾光善
    • Total Pages
      214
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] エピジェネティクスの産業応用(分担執筆)2014

    • Author(s)
      高瀬隆太、日野信次朗、中尾光善.
    • Total Pages
      393
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Book] バイオ画像解析 手とり足とりガイド(分担執筆)2014

    • Author(s)
      斉藤典子、坂本智代美、松森はるか、中尾光善、Ilya G. Goldberg
    • Total Pages
      221
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] エピジェネティクスと病気(分担執筆)2013

    • Author(s)
      阿南浩太郎、中尾光善、日野信次朗.
    • Total Pages
      280
    • Publisher
      メディカル・ドゥ
    • Related Report
      2013 Annual Research Report
  • [Book] エピジェネティクスと病気(分担執筆)2013

    • Author(s)
      藤原沙織、冨田さおり、中尾光善.
    • Total Pages
      280
    • Publisher
      メディカル・ドゥ
    • Related Report
      2013 Annual Research Report
  • [Book] エピジェネティクスキーワード事典(分担執筆)2013

    • Author(s)
      斉藤典子、松森はるか、Mohamed O. Abdalla、藤原沙織、安田洋子、中尾光善.
    • Total Pages
      315
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] エピジェネティクスキーワード事典(分担執筆)2013

    • Author(s)
      石原宏、中元雅史、中尾光善.
    • Total Pages
      315
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 栄養とエピジェネティクス―食による身体変化と生活習慣病の分子機構2012

    • Author(s)
      中尾光善
    • Total Pages
      141
    • Publisher
      建帛社
    • Related Report
      2012 Annual Research Report
  • [Book] シグナル伝達キーワード事典2012

    • Author(s)
      日野信次朗
    • Total Pages
      349
    • Publisher
      羊土社
    • Related Report
      2012 Annual Research Report
  • [Book] 遺伝情報の発現制御-転写機構からエピジェネティクスまで(David S.Latchman原著)(分担翻訳)2012

    • Author(s)
      中尾光善
    • Total Pages
      429
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2011 Annual Research Report
  • [Book] 栄養とエピジェネティクス-食による身体変化と生活習慣病の分子機構-(分担執筆)2012

    • Author(s)
      中尾光善
    • Publisher
      建帛社(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 染色体と細胞核のダイナミクス(分担執筆)2012

    • Author(s)
      斉藤典子
    • Publisher
      化学同人(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Remarks] 熊本大学発生医学研究所

    • URL

      http://www.imeg.kumamoto-u.ac.jp

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 熊本大学発生医学研究所

    • URL

      http://www.imeg.kumamoto-u.ac.jp

    • Related Report
      2013 Annual Research Report
  • [Remarks] 熊本大学発生医学研究所ホームページ

    • URL

      http://www.imeg.kumamoto-u.ac.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.imeg.kumamoto-u.ac.jp

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 神経変性疾患治療剤2016

    • Inventor(s)
      谷原秀信、岩尾圭一郎、中尾光善、林秀樹、日野信次朗、 堤孝之
    • Industrial Property Rights Holder
      熊本大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-011705
    • Filing Date
      2016-01-25
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 誘導多能性幹細胞の識別方法2011

    • Inventor(s)
      中尾光善、斉藤典子、徳永和明、小林民代
    • Industrial Property Rights Holder
      オリンパス株式会社、熊本大学
    • Industrial Property Number
      2011-091405
    • Filing Date
      2011-04-15
    • Related Report
      2011 Annual Research Report
  • [Funded Workshop] International Symposium on Nuclear Structure and Epigenetics2015

    • Place of Presentation
      熊本大学発生医学研究所(熊本市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2011-08-01   Modified: 2022-02-07  

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