Lipid mediators in allergy and immunity

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 23116101
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Research Institution: Kyoto University
• Principal Investigator: MIYACHI Yoshiki 京都大学, 医学(系)研究科(研究院), 教授 (30127146)
• Co-Investigator(Kenkyū-buntansha): KITOH Akihiko 京都大学, 医学研究科, 助教 (40508438) ; HONDA Tetsuya 京都大学, 医学研究科, 准教授 (40452338) ; 江川 形平 京都大学, 医学研究科, 助教 (50511812)
• Project Fiscal Year: 2011-04-01 – 2015-03-31
• Project Status: Completed(Fiscal Year 2014)
• Budget Amount: ¥56,420,000 (Direct Cost : ¥43,400,000、Indirect Cost : ¥13,020,000); Fiscal Year 2014 : ¥17,420,000 (Direct Cost : ¥13,400,000、Indirect Cost : ¥4,020,000); Fiscal Year 2013 : ¥18,590,000 (Direct Cost : ¥14,300,000、Indirect Cost : ¥4,290,000); Fiscal Year 2012 : ¥20,410,000 (Direct Cost : ¥15,700,000、Indirect Cost : ¥4,710,000)
• Keywords: 免疫 / アレルギー / 皮膚科学 / 脂質メディエーター / プロスタグランジン / ペラグラ / 好酸球性膿疱性毛包炎 / インドメタシン / 炎症性皮膚疾患 / ランゲルハンス細胞 / 樹状細胞 / 皮膚アレルギー / 皮膚免疫

Outline of Final Research Achievements

Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released in various pathophysiological conditions. They induce a range of actions mediated through their respective receptors expressed on target cells. It has been demonstrated that each prostanoid receptor has multiple functions and that the effect of receptor stimulation can vary depending on context; this sometimes results in opposing effects, such as simultaneous excitatory and inhibitory outcomes. The balance between the production of each prostanoid and the expression of its receptors has been shown to be important for maintaining homeostasis but also involved in the development of various pathological conditions such as allergy.

Research Output

• [Journal Article] Eosinophilic pustular folliculitis: The transition in sex differences and interracial characteristics between 1965 and 2013 (2015)
  • Author(s): Nomura T, Katoh M, Yamamoto Y, Kabashima K, Miyachi Y.
  • Journal Title: J Dermatol Volume : in press Pages : in press
  • DOI: 10.1111/1346-8138.12783.
• [Journal Article] Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis (2014)
  • Author(s): Nakashima C, Otsuka A, Kitoh A, Honda T, Egawa G, Nakajima S, Nakamizo S, Arita M, Kubo M, Miyachi Y, Kabashima K
  • Journal Title: J Allergy Clin Immunol Volume : in press Pages : in press
  • DOI: 10.1016/j.jaci.2014.02.026
• [Journal Article] Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression (2014)
  • Author(s): Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
  • Journal Title: J Allergy Clin Immunol Volume : 133 Pages : 139-46
  • DOI: 10.1016/j.jaci.2013.07.027
• [Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin (2014)
  • Author(s): Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K.
  • Journal Title: Nat Immunol. Volume : 15 Pages : 1064-1069
  • DOI: 10.1038/ni.2992.
• [Journal Article] Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis. (2014)
  • Author(s): Nakashima C, Otsuka A, Kitoh A, Honda T, Egawa G, Nakajima S, Nakamizo S, Arita M, Kubo M, Miyachi Y, Kabashima K.
  • Journal Title: J Allergy Clin Immunol. Volume : 134 Pages : 100-107
  • DOI: 10.1016/j.jaci.2014.02.026.
• [Journal Article] IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models. (2014)
  • Author(s): Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga CS, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K.
  • Journal Title: J Invest Dermatol. Volume : 134 Pages : 2122-2130
  • DOI: 10.1038/jid.2014.51
• [Journal Article] rostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production. (2013)
  • Author(s): Sugita K, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K
  • Journal Title: Scientific reports Volume : 3 Pages : 2973
  • DOI: 10.1038/srep02973
• [Journal Article] Prostaglandin E2-EP3 axis in fine-tuning excessive skin inflammation by restricting dendritic cell functions (2013)
  • Author(s): Shiraishi N, Nomura T, Tanizaki H, Nakajima S, Narumiya S, Miyachi Y, Tokura Y, Kabashima K
  • Journal Title: PLoS ONE Volume : 8(7) Pages : e69599
  • DOI: 10.1371/journal.pone.0069599
• [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens (2013)
  • Author(s): Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y, Kabashima K
  • Journal Title: Nat Commun Volume : 4 Pages : 1739
  • DOI: 10.1038/ncomms2740
• [Journal Article] PGD2 induces eotaxin-3 via PPARγ from sebocytes : a possible pathogenesis of eosinophilic pustular folliculitis (2012)
  • Author(s): Nakahigashi K, Doi H, Otsuka A, Hirabayashi T, Murakami M, Urade Y, Tanizaki H, Egawa G, Miyachi Y, Kabashima K
  • Journal Title: J Allergy Clin Immunol Volume : 129 Pages : 536-543
  • DOI: 10.1016/j.jaci.2011.11.034
• [Journal Article] Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling (2012)
  • Author(s): Nakajima S, Igyarto BZ, Honda T, Egawa G, Otsuka A, Hara-Chikuma M, Watanabe N, Ziegler SF, Tomura M, Inaba K, Miyachi Y, Kaplan DH, Kabashima K
  • Journal Title: J Allergy Clin Immunol Volume : (in press)
  • DOI: 10.1016/j.jaci.2012.01.063
• [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity (2011)
  • Author(s): Otsuka A, Kubo M, Honda T, Egawa G, Nakajima S, Tanizaki H, Kim B, Matsuoka S, Watanabe T, Nakae S, Miyachi Y, Kabashima K
  • Journal Title: Plos One Volume : 6 Pages : e25538
  • DOI: 10.1371/journal.pone.0025538
• [Journal Article] Hypertrichosis around a leg ulcer being treated with prostaglandin E1 ointment (2011)
  • Author(s): Honda T, Koreeda S, Miyachi Y, Kabashima K
  • Journal Title: J Am Acad Dermatol Volume : 64 Pages : 1212-1213
  • DOI: 10.1016/j.jaad.2009.10.022
• [Journal Article] Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells (2011)
  • Author(s): Hara-Chikuma M, Sugiyama Y, Kabashima K, Sohara E, Uchida S, Sasaki S, Ioue S, Miyachi Y
  • Journal Title: FASEB J Volume : 26 Pages : 211-218
  • DOI: 10.1016/j.jaad.2009.10.022
• [Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis (2011)
  • Author(s): Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
  • Journal Title: Blood Volume : 117 Pages : 500-509
  • DOI: 10.1096/fj.11-186627
• [Presentation] Skin diseases first described by Japanese dermatologists (2011)
  • Author(s): Yoshiki Miyachi
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20110522-20110530
• [Book] Eosinophilic Pustular Folliculitis. In : Asian skin and skin diseases (2011)
  • Author(s): Yoshiki Miyachi
  • Total Pages: 6
  • Publisher: Medrang, Seoul
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~skin/
• [Remarks] 京都大学医学研究科 皮膚科学教室
  • URL: http://www.kuhp.kyoto-u.ac.jp/~skin/
• [Remarks] 京都大学皮膚科学講座
  • URL: http://www.kuhp.kyoto-u.ac.jp/~skin/index.html