• Search Research Projects
  • Search Researchers
  1. Back to previous page

Lipid mediators in allergy and immunity

Planned

Project AreaMachineries of bioactive lipids in homeostasis and diseases
Project/Area Number23116101
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

MIYACHI Yoshiki  京都大学, 医学(系)研究科(研究院), 教授 (30127146)

Co-Investigator(Kenkyū-buntansha) HONDA Tetsuya  京都大学, 医学研究科, 准教授 (40452338)
KITOH Akihiko  京都大学, 医学研究科, 助教 (40508438)
江川 形平  京都大学, 医学研究科, 助教 (50511812)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed(Fiscal Year 2014)
Budget Amount *help
¥56,420,000 (Direct Cost : ¥43,400,000、Indirect Cost : ¥13,020,000)
Fiscal Year 2014 : ¥17,420,000 (Direct Cost : ¥13,400,000、Indirect Cost : ¥4,020,000)
Fiscal Year 2013 : ¥18,590,000 (Direct Cost : ¥14,300,000、Indirect Cost : ¥4,290,000)
Fiscal Year 2012 : ¥20,410,000 (Direct Cost : ¥15,700,000、Indirect Cost : ¥4,710,000)
Keywords免疫 / アレルギー / 皮膚科学 / 脂質メディエーター / プロスタグランジン / ペラグラ / アトピー性皮膚炎 / マウスモデル / 脂質メデイエーター / 好酸球性膿疱性毛包炎 / インドメタシン / 炎症性皮膚疾患 / ランゲルハンス細胞 / 樹状細胞 / 皮膚アレルギー / 皮膚免疫
Outline of Final Research Achievements

Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released in various pathophysiological conditions. They induce a range of actions mediated through their respective receptors expressed on target cells. It has been demonstrated that each prostanoid receptor has multiple functions and that the effect of receptor stimulation can vary depending on context; this sometimes results in opposing effects, such as simultaneous excitatory and inhibitory outcomes. The balance between the production of each prostanoid and the expression of its receptors has been shown to be important for maintaining homeostasis but also involved in the development of various pathological conditions such as allergy.

Report

(5results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report

Research Products

(23results)

All 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] Eosinophilic pustular folliculitis: The transition in sex differences and interracial characteristics between 1965 and 20132015

    • Author(s)
      Nomura T, Katoh M, Yamamoto Y, Kabashima K, Miyachi Y.
    • Journal Title

      J Dermatol

      Volume : in press Pages : 343-352

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models.2014

    • Author(s)
      Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga CS, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K.
    • Journal Title

      J Invest Dermatol.

      Volume : 134 Pages : 2122-2130

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression2014

    • Author(s)
      Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
    • Journal Title

      J Allergy Clin Immunol

      Volume : 133 Pages : 139-46

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.2014

    • Author(s)
      Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K
    • Journal Title

      Nature immunology

      Volume : 15 Issue : 11 Pages : 1064-1069

    • Publisher
      Nature Publishing Group
    • PMID
      25240383
    • Year and Date
      2014-09-21
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis2014

    • Author(s)
      Nakashima C, Otsuka A, Kitoh A, Honda T, Egawa G, Nakajima S, Nakamizo S, Arita M, Kubo M, Miyachi Y, Kabashima K
    • Journal Title

      J Allergy Clin Immunol

      Volume : in press Issue : 1 Pages : 100-107

    • Publisher
      Kyoto University
    • Year and Date
      2014-07-23
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] rostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.2013

    • Author(s)
      Sugita K, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K
    • Journal Title

      Scientific reports

      Volume : 3 Pages : 2973-2973

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2-EP3 axis in fine-tuning excessive skin inflammation by restricting dendritic cell functions2013

    • Author(s)
      Shiraishi N, Nomura T, Tanizaki H, Nakajima S, Narumiya S, Miyachi Y, Tokura Y, Kabashima K
    • Journal Title

      PLoS ONE

      Volume : 8(7)

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophils are required for the induction of Th2 immunity to haptens and peptide antigens2013

    • Author(s)
      Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y, Kabashima K
    • Journal Title

      Nature Communications

      Volume : 4 Pages : 1739-1739

    • Publisher
      Nature Publishing Group
    • Year and Date
      2013-04-23
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical clinical appearance of eosinophilic pustular folliculitis of seborrheic areas of the face.2012

    • Author(s)
      Matsumura Y, Miyachi Y.
    • Journal Title

      Eur J Dermatol.

      Volume : 22(5) Pages : 658-662

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGD_2 induces eotaxin-3 via PPARγ from sebocytes : a possible pathogenesis of eosinophilic pustular folliculitis2012

    • Author(s)
      Nakahigashi, K., et al
    • Journal Title

      J.Allergy Clin.Immunol.

      Volume : 129 Pages : 536-543

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling.2012

    • Author(s)
      Nakajima S, Igyarto BZ, Honda T, Egawa G, Otsuka A, Hara-Chikuma M, Watanabe N, Ziegler SF, Tomura M, Inaba K, Miyachi Y, Kaplan DH, Kabashima K
    • Journal Title

      The Journal of allergy and clinical immunology

      Volume : 129 Issue : 4 Pages : 1048-1055.e6

    • Publisher
      Mosby, Inc.
    • PMID
      22385635
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 二光子顕微鏡による皮膚免疫応答の可視化2012

    • Author(s)
      江川形平
    • Journal Title

      医学のあゆみ

      Volume : 242 Pages : 780-784

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【生理活性脂質】 脂質メディエーターとアレルギー疾患2012

    • Author(s)
      本田哲也
    • Journal Title

      臨床検査

      Volume : 56巻2号 Pages : 203-208

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.2012

    • Author(s)
      Hara-Chikuma M
    • Journal Title

      FASEB J.

      Volume : 26 Pages : 211-218

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake.2012

    • Author(s)
      1. Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y.
    • Journal Title

      The Journal of experimental medicine

      Volume : 209 Issue : 10 Pages : 1743-1752

    • Publisher
      The Rockefeller University Press
    • PMID
      22927550
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity2011

    • Author(s)
      A. Otsuka, M. Kubo, T. Honda, G. Egawa, S. Nakajima, H. Tanizaki, B. Kim, S. Matsuoka, T. Watanabe, S. Nakae, Y. Miyachi and K. Kabashima
    • Journal Title

      PLoS ONE

      Volume : vol.6, No.9 Pages : 229-233

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertrichosis around a leg ulcer being treated with prostaglandin E1 ointment2011

    • Author(s)
      Honda T, Koreeda S, Miyachi Y, Kabashima K
    • Journal Title

      J Am Acad Dermatol

      Volume : 64 Pages : 1212-1213

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Skin diseases first described by Japanese dermatologists2011

    • Author(s)
      Yoshiki Miyachi
    • Organizer
      22nd World Congress of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report
  • [Book] What's new in 皮膚科学:二光子顕微鏡で見る皮膚の正常解剖2012

    • Author(s)
      江川形平
    • Total Pages
      1
    • Publisher
      メデイカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] Eosinophilic Pustular Folliculitis. In : Asian skin and skin diseases2011

    • Author(s)
      Yoshiki Miyachi
    • Total Pages
      6
    • Publisher
      Medrang, Seoul
    • Related Report
      2011 Annual Research Report
  • [Remarks] 京都大学皮膚科学講座

    • URL
      http://www.kuhp.kyoto-u.ac.jp/~skin/index.html
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学医学研究科 皮膚科学教室

    • URL
      http://www.kuhp.kyoto-u.ac.jp/~skin/
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL
      http://www.kuhp.kyoto-u.ac.jp/~skin/
    • Related Report
      2011 Annual Research Report

URL :

Published : 2013-05-15   Modified : 2018-03-28  

Information FAQ News Terms of Use

Powered by NII kakenhi